dr. sc. Nikolina Stojanović

1. Stojanović N*, Dekanić A*, Paradžik M, Majhen D, Ferenčak K, Ruščic J, Bardak I, Supina C, Tomičić MT, Christmann M, Osmak M, Ambriović-Ristov A. Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple- negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology. 94(6)1334-1351, 2018. *equal contribution
2. Hayek SS, Koh KH, Grams ME, Wei C, Ko Y-A, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanović N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. Nature Medicine. 23:945-953, 2017.
3. Christmann M., Diesler K., Majhen D., Steigerwald C., Berte N., Freund H., Stojanović N., Kaina B., Osmak M., Ambriović-Ristov A., Tomicic MT. Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. Oncotarget, 8:27754-27771, 2016.
4. Stojanović N., Brozovic A., Majhen D., Bosnar M.H., Fritz G., Osmak M., Ambriović-Ristov A. Integrin αvβ3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418). Biochimica et Biophysica Acta. 1863(8):1969-78, 2016.For this work N. Stojanović obtained following awards: "Željko Trgovčević" Award for 2016; Award of The society of university teachers, scholars and other scientists for 2016; Award of Division of Molecular Biology Ruđer Bošković Institute for 2016
5. Steiner I.*, Stojanović N.*, Bolje A., Brozovic A., Polančec D., Ambriović-Ristov A., Radić Stojković M., Piantanida I, Eljuga D., Košmrlj J., Osmak M. Discovery of ‘click’ 1,2,3-triazolium salts as potential anticancer drugs. Radiology and Oncology. 19;50(3):280-288, 2016. *equal contribution
6. Krüger K, Thomale J, Stojanović N, Osmak M, Henninger C, Bormann S, Fritz G. Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury. Biochim Biophys Acta. 2015 Mar;1854(3):685-98. doi: 10.1016/j.bbamcr.2014.12.033.
7. Sommer MG, Kureljak P, Urankar D, Schweinfurth D, Stojanović N, Bubrin M, Gazvoda M, Osmak M, Sarkar B, Košmrlj J. Combining [arene-Ru] with azocarboxamide to generate a complex with cytotoxic properties. Chemistry. 2014 Dec 22;20(52):17296-9. doi: 10.1002/chem.201404448.
8. Brozovic A, Stojanović N, Ambriović-Ristov A, Brozović Krijan A, Polanc S, Osmak M. 3-Acetyl-bis(2-chloro-4-nitrophenyl)triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anticancer Drugs. 2014 Mar;25(3):289-95. doi: 10.1097/CAD.0000000000000060.
9. Majhen D, Stojanović N, Vukić D, Pichon C, Leduc C, Osmak M, Ambriović-Ristov A. Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation. PLoS One. 2014 Jan 22;9(1):e86698. doi: 10.1371/journal.pone.0086698.
10. Vajs J, Soviček S, Kureljak P, Stojanović N, Steiner I, Eljuga D, Urankar D, Kočevar M, Košmrlj J, Polanc S, Osmak M. Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents. Acta Chim Slov. 2013;60(4):842-52.
11. Stojanovic N, Urankar D, Brozović A, Ambriović-Ristov A, Osmak M, Kosmrlj J. Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta Chim Slov. 2013;60(2):368-74.
12. Majhen D, Stojanović N, Špeljko T, Brozovic A, De Zan T, Osmak M, Ambriović-Ristov A. Increased expression of the coxsackie and adenovirus receptor downregulates αvβ3 and αvβ5 integrin expression and reduces cell adhesion and migration. Life Sci. 2011 Aug 15;89(7-8):241-9. doi: 10.1016/j.lfs.2011.06.009.

Radovi u časopisima

Znanstveni i pregledni radovi

• Stojanović, N., Dekanić, A., Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M. & Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple- negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology, 118, 113027, 46 doi:10.1124/mol.118.113027.

  doi

• Hayek, S., Koh, K., Grams, M., Wei, C., Ko, Y., Li, J., Samelko, B., Lee, H., Dande, R., Lee, H., Hahm, E., Peev, V., Tracy, M., Tardi, N., Gupta, V., Altintas, M., Garborcauskas, G., Stojanović, N., Winkler, C., Lipkowitz, M., Tin, A., Inker, L., Levey, A., Zeier, M., Freedman, B., Kopp, J., Skorecki, K., Coresh, J., Quyyumi, A., Sever, S. & Reiser, J. (2017) A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. Nature medicine, 23, 945-953 doi:10.1038/nm.4362.

  doi

• Christmann, M., Diesler, K., Majhen, D., Steigerwald, C., Berte, N., Freund, H., Stojanović, N., Kaina, B., Osmak, M., Ambriović-Ristov, A. & Tomicic, M. (2017) Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. Oncotarget, 8, 27754-27771 doi:10.18632/oncotarget.10897.

  doifulir.irb.hr

• Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.

  doi

• Steiner, I., Stojanović, N., Bolje, A., Brozović, A., Polančec, D., Ambriović-Ristov, A., Radić Stojković, M., Piantanida, I., Eljuga, D., Košmrlj, J. & Osmak, M. (2015) Discovery of ‘click’ 1, 2, 3-triazolium salts as potential anticancer drugs. Radiology and oncology, 50 (3), 280-288 doi:10.1515/raon-2016-0027.

  doi

• Krüger, K., Thomale, J., Stojanović, N., Osmak, M., Henninger, C., Bormann, S. & Fritz, G. (2015) Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury. Biochimica et biophysica acta-molecular cell research, 1853 (3), 685-698 doi:10.1016/j.bbamcr.2014.12.033.

  doi

• Sommer, M., Kureljak, P., Urankar, D., Schweinfurth, D., Stojanović, N., Bubrin, M., Gazvoda, M., Osmak, M., Sarkar, B. & Košmrlj, J. (2014) Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties. Chemistry : a European journal, 20 (52), 17296-17299 doi:10.1002/chem.201404448.

  doi

• Brozović, A., Stojanović, N., Ambriović-Ristov, A., Brozović Krijan, A., Polanc, S. & Osmak, M. (2014) 3-Acetyl-bis(2-chloro-4-nitrophenyl) triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anti-cancer drugs, 25 (3), 289-295 doi:10.1097/CAD.000000000000006.

  doi

• Majhen, D., Stojanović, N., Vukić, D., Pichon, C., Leduc, C., Osmak, M. & Ambriović-Ristov, A. (2014) Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-regulation. PLoS One, 9 (1) doi:10.1371/journal.pone.0086698.

  doi

• Vajs, J., Soviček, S., Kureljak, P., Stojanović, N., Steiner, I., Eljuga, D., Urankar, D., Kočevar, M., Košmrlj, J., Polanc, S. & Osmak, M. (2013) Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents. Acta chimica Slovenica, 60 (4), 842-852.

  fulir.irb.hr

• Stojanović, N., Urankar, D., Brozović, A., Ambriović-Ristov, A., Osmak, M. & Košmrlj, J. (2013) Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta chimica Slovenica, 60 (2), 368-374.

  fulir.irb.hr

• Majhen, D., Stojanović, N., Špeljko, T., Brozović, A., De Zan, T., Osmak, M. & Ambriović-Ristov, A. (2011) Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life sciences, 89 (7/8), 241-249 doi:10.1016/j.lfs.2011.06.009.

  doi

Ocjenski radovi

Doktorske disertacije

• Stojanović, N. (2014) 'Otpornost na protutumorske lijekove posredovana integrinom αvβ3 u stanicama karcinoma pločastog epitela jezika čovjeka', doktorska disertacija, Sveučilišni poslijediplomski interdisciplinarni doktorski studij Molekularne bioznanosti, Zagreb.