dr. sc. Katja Ester

Zagreb 1998 Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, Molekularna biologija, dipl.inž. biologije

Zagreb 2006 Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, Molekularna biologija, dr.sc. biologije

Pomoć zaklade HAZU za projekt pod naslovom: Mehanizmi smrti tumorskih stanica djelovanjem apoptina

Pomoć zaklade HAZU za projekt pod naslovom:Djelovanje apoptina na tumorske matične stanice (Effects of Apoptin on Cancer Stem Cells)

• Treća nagrada, Hrvatsko natjecanje gitarista, Velika Gorica, Hrvatska, 1986
• Učenička stipendija kao nagrada za najbolje učenike, 1988-1992
• Priznanje za uspjeh tijekom školovanja, V Gimnazija, Zagreb, 1992
• Nagrada za najbolji poster na kongresu: Third Croatian Congress of Pharmacology, Zagreb, Septembar 18-21, 2001.
• FEMS-ova  nagrada za perspektivne mlade znanstvenike u vidu stipendije za sudjelovanje na kongresu ‘Workshop on molecular pathogenesis of Marek’s disease and avian immunology’, Cipar, listopad 2002.

Nastava u sklopu kolegija: Funkcionalna genomika, Poslijediplomski interdisciplinarni studij: Molekularne Bioznanosti, Sveučilište u Dubrovniku

Nositelj kolegija: Biologija, OKIRU, ALU Zagreb

1. Ester, Katja; Supek, Fran; Majsec, Kristina; Marjanović, Marko; Lembo, David; Donalisio, Manuela; Šmuc, Tomislav;  Jarak, Ivana; Kraminski-Zamola, Grace; Kralj, Marijeta.  Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells. Investigational New Drugs. 2012 Apr;30(2):450-67.
2. Ester, Katja; Hranjec, Marijana; Piantanida, Ivo; Caleta,  Irena; Jarak, Ivana; Pavelić, Krešimir; Kralj, Marijeta;  Karminski-Zamola, Grace. Novel Derivatives of Pyridyl-Benzo(b)thiophene-2-carboxamides  and Benzo(b)thieno(2,3-c)naphthyridin-2-ones: Minor Structural  Variations Provoke Major Differences of Antitumor Action Mechanisms. Journal of Medicinal Chemistry. 52 (2009), 8; 2482-2492.

Radovi u časopisima

Znanstveni i pregledni radovi

• Sambol, M., Ester, K., Landgraf, S., Mihaljević, B., Cindrić, M., Kralj, M. & Basarić, N. (2019) Competing photochemical reactions of bis-naphthols and their photoinduced antiproliferative activity. Photochemical & photobiological sciences, 18, 1197-1211 doi:10.1039/c8pp00532j.

  doi

• Guberović, I., Marjanović, M., Mioč, M., Ester, K., Martin-Kleiner, I., Šumanovac Ramljak, T., Mlinarić-Majerski, K. & Kralj, M. (2018) Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells. Scientific Reports, 8 (1), 14467, 14 doi:10.1038/s41598-018-32770-y.

  doifulir.irb.hrwww.nature.com

• Levatić, J., Pavić, K., Perković, I., Uzelac, L., Ester, K., Kralj, M., Kaiser, M., Rottmann, M., Supek, F. & Zorc, B. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European journal of medicinal chemistry, 146, 651-667 doi:10.1016/j.ejmech.2018.01.062.

  doi

• Knežević Teofilović, N., Bihi, M., Radić Stojković, M., Tumir, L., Ester, K., Kralj, M., Majhen, D., Oršolić, N., Lepur, A., Vrbanec, D., Markotić, A., Dembić, Z., Weber, A., Piantanida, I., Vugrek, O., Diken, M. & Knežević, J. (2017) 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 27 (7), 1530-1537 doi:10.1016/j.bmcl.2017.02.048.

  doi

• Pavić, K., Perković, I., Gilja, P., Kozlina, F., Ester, K., Kralj, M., Schols, D., Hadjipavlou- Litina, D., Pontiki, E. & Zorc, B. (2016) Design, synthesis and biological evaluation of novel primaquine-cinnamic acid conjugates of the amide and acylsemicarbazide type. Molecules, 21 (12), 1629, 24 doi:10.3390/molecules21121629.

  doifulir.irb.hrwww.mdpi.com

• Perković, I., Antunović, M., Marijanović, I., Pavić, K., Ester, K., Kralj, M., Vlainić, J., Kosalec, I., Schols, D., Hadjipavlou-Litina, D., Pontiki, E. & Zorc, B. (2016) Novel urea and bis-urea primaquine derivatives with hydroxyphenyl and halogenphenyl substituents: synthesis and biological evaluation. European journal of medicinal chemistry, 124, 622-636 doi:10.1016/j.ejmech.2016.08.021.

  doi

• Sović, I., Viskić, M., Bertoša, B., Ester, K., Kralj, M., Hranjec, M. & Karminski-Zamola, G. (2015) Exploring antiproliferative activity of heteroaromatic amides and their fused derivatives using 3D-QSAR, synthesis and biological tests. Monatshefte für Chemie, 146 (9), 1503-1517 doi:10.1007/s00706-015-1478-8.

  doi

• Racane, L., Stojković, R., Tralić- Kulenović, V., Cerić, H., Đaković, M., Ester, K., Mišir Krpan, A. & Radić Stojković, M. (2014) Interactions with polynucleotides and antitumor activity of amidino and imidazolinyl substituted 2-phenylbenzothiazole mesylates. European journal of medicinal chemistry, 86, 406-419 doi:10.1016/j.ejmech.2014.08.072.

  doi

• Perin, N., Nhili, R., Ester, K., Laine, W., Karminski-Zamola, G., Kralj, M., David-Cordonnier, M. & Hranjec, M. (2014) Synthesis, antiproliferative activity and DNA binding properties of novel 5-aminobenzimidazo[1, 2-a]quinoline-6-carbonitriles. European journal of medicinal chemistry, 80, 218-227 doi:10.1016/j.ejmech.2014.04.049.

  doi

• Ester, K., Supek, F., Majsec, K., Marjanović, M., Lembo, D., Donalisio, M., Šmuc, T., Jarak, I., Karminski-Zamola, G. & Kralj, M. (2012) Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells. Investigational new drugs, 30 (2), 450-467 doi:10.1007/s10637-010-9571-7.

  doi

• Šimunović, M., Perković, I., Zorc, B., Ester, K., Kralj, M., Hadjipavlou-Litina, D. & Pontiki, E. (2009) Urea and carbamate derivatives of primaquine: Synthesis, cytostatic and antioxidant activities. Bioorganic and Medicinal Chemistry, 17 (15), 5605-5613. (https://www.bib.irb.hr/420544).

• Ester, K., Ćurković-Perica, M. & Kralj Marijeta (2009) The phytohormone auxin induces G1 cell cycle arrest of human tumor cells. Planta Medica, 75 (13), 1423-1426.

• Ester, K., Hranjec, M., Piantanida, I., Ćaleta, I., Ivana, J., Pavelić, K., Kralj, M. & Karminski-Zamola, G. (2009) Novel Derivatives of Pyridyl-Benzo[b]thiophene-2-carboxamides and Benzo[b]thieno[2, 3- c]naphthyridin-2-ones: Minor Structural Variations Provoke Major Differences of Antitumor Action Mechanisms. Journal of Medicinal Chemistry, 52 (8), 2482-2492.

• Džimbeg, G., Zorc, B., Kralj, M., Ester, K., Pavelić, K., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E. & Mintas, M. (2008) The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry, 43 (6), 1180-1187 doi:10.1016/j.ejmech.2007.09.001.

  doi

• Starčević, K., Kralj, M., Ester, K., Sabol, I., Grce, M., Pavelić, K. & Karminski-Zamola, G. (2007) Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles. Bioorganic & medicinal chemistry, 15 (13), 4419-4426 doi:10.1016/j.bmc.2007.04.032.

  doifulir.irb.hr

• Starčević, K., Kralj, M., Ester, K. & Karminski-Zamola, G. (2007) Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives. Heterocycles, 71 (3), 647-656.

• Rajić, Z., Zorc, B., Raić-Malić, S., Ester, K., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E. & Mintas, M. (2006) Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations. Molecules, 11 (11), 837-848.

• Starčević, K., Ćaleta, I., Cinčić, D., Kaitner, B., Kralj, M., Ester, K. & Karminski-Zamola, G. (2006) Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides. Heterocycles, 68 (11), 2285-2299.

• Quere, P., Rivas, C., Ester, K., Novak, R. & Ragland, W. (2005) Abundance of IFN-alpha and IFN gamma mRNA in blood of resistant and susceptible chickens infected with Marek's disease virus (MDV) or vaccinated with turkey herpesvirus ; and MDV inhibition of subsequent induction of IFN gene transcription. Archives of virology, 150 (3), 507-519.

• Crnek-Kunstelj, V., Ester, K. & Stipić, J. (2002) Role of retinoic acid and DNA methylation in differentiation of mammalian embryo in vitro.. Periodicum biologorum, 104 (1), 55-66.

• Ragland, W., Novak, R., El-Attrache, J., Savić, V. & Ester, K. (2002) Chicken Anemia Virus and Infectious Bursal Disease Virus Interfere with Transcription of Chicken IFN-alpha and IFN-gamma mRNA. Journal of interferon and cytokine research, 22 (4), 437-441.

• Ragland, W., Novak, R., Ester, K. & Savić, V. (2001) Evaluation of immune status in chickens. Periodicum biologorum, 103 (2), 115-118.

• Novak, R., Ester, K., Savić, V., Sekellick, M., Marcus, P., Lowenthal, J., Vainio, O. & Ragland, W. (2001) Immune status assessment by abundance of IFN-alpha and IFN-gamma mRNA in chicken blood.. Journal of Interferon and Cytokine Research, 21 (8), 643-651.

Radovi u zbornicima skupova

Znanstveni radovi u zbornicima skupova

• Savić, V., Ragland, W., Novak, R. & Ester, K. (2001) Infectious bursal disease outbreak: experimental infection of broilers with evidence of significantly reduced body weight gain and interference with transcription for interferon.. U: Kaleta, E. (ur.)Infectious Bursal Disease and Chicken Infectious Anaemia.

• Ragland, W., Novak, R., El-Attrache, J. & Ester, K. (2001) Chicken infectious anaemia virus interferes with transcription for chicken interferon alpha and gamma.. U: Kaleta, E. (ur.)Infectious Bursal Disease and Chicken Infectious Anaemia.

Ocjenski radovi

Doktorske disertacije

• Ester, K. (2006) 'Immune status assessment by abundance of interferon alpha and gamma mRNA in chicken blood', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Hrvatsko biološko društvo 1885
Europsko društvo za istraživanje raka EACR

FEMS

COST

Volonterski rad:

• Klinika za ženske bolesti i porode, Zagreb, 1996
• Zavod za molekularnu medicinu, Laboratorij za molekularnu patologiju, Institut ‘Ruđer Bošković’, 1999-2000.