Laboratorij za molekularnu virologiju i bakteriologiju

Laboratorij se bavi molekularnim analizama infektivnih bolesti, posebice papiloma virusom čovjeka i povezanim tumorima

Slika LMVB
Misija

Misija Laboratorija za molekularnu virologiju i bakteriologiju je proširivanje znanja i razumijevanja prirode tumora čovjeka povezanih sa infektivnim agensima u svrhu poboljšanja i razvijanja novih pristupa u dijagnostici, liječenju i prevenciji tih bolesti.

Djelatnost
  • Bazična istraživanja molekularne patogeneze humanih papiloma virusa (HPV)
  • Epidemiološka istraživanja HPV-a u raznim sijelima 
  • Istraživanja epigenetike HPV-povezanih bolesti
  • Istraživanja uloge onkogena E6 i E7 HPV-a u razvoju HPV-povezanih bolesti
  • Laboratorij je zavodska jedinica za molekularnu analizu virusnih i bakterijskih infekcija u čovjeka
  • Laboratorij je zavodska jedinica za izolaciju nukleinskih kiselina pomoću automatskog sustava EZ1
  • Laboratorij održava hrvatsku banku DNA i RNA stanica prekanceroza i karcinoma povezanih s HPV-om
  • Laboratorij održava stanične i bakterijske kulture za uzgoj ili/i ekspresiju gena HPV-a
Publikacije u zadnjih 5 godina
  1. Milutin Gašperov NSabol IBožinović K, Mravak-Stipetić M, Dediol E, Licastro D, Dal Monego S, Grce M*. DNA methylome in head and neck cancer and potentially malignant oral lesions. Epigenomics 2019 (submitted for revision) Q1 Genetics&Heredity
  2. Bennett Saidu NE, Filić V, Thomas M, Sarabia-Vega V, Ðukić A, Miljković F, Banks L, Tomaić V*.  PDZ Domain-Containing Protein NHERF-2 is a Novel Target of Human Papillomavirus type 16 (HPV-16) and HPV-18.  J Virol. 2019 Oct 9. pii: JVI.00663-19. doi: 10.1128/JVI.00663-19. Q1 Virology
  3. Bennett Saidu NE*, Kavian N, Leroy K, Jacob C, Nicco C, Batteux F, Alexandre J. Dimethyl fumarate, a two-edged drug: Current status and future directions. Med Res Rev. 2019 Sep;39(5):1923-1952. doi: 10.1002/med.21567. Q1 Pharmacology, Medical chemistry
  4. Božinović KSabol I, Jakovčević A, Rakušić Z, Šekerija M, Lukinović J, Prgomet D, Grce M*. Not all HPV-positive HNSCC confer Better Outcome: Retrospective Analysis of Oropharyngeal Cancer Patients. Plos One 2019 Feb 1;14(2):e0211577. doi: 10.1371/journal.pone.0211577. Q2 Multidisciplinary
  5. Božinović KSabol I, Dediol E, Milutin Gašperov N, Manojlović S, Vojtechova Z, Tachezy R, Grce M*. Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Sci Rep. 2019 Feb 19;9(1):2306. doi: 10.1038/s41598-019-38797-z. Q1 Multidisciplinary
  6. Brzak BL*, Cigić L, Baričević M, Sabol I, Mravak-Stipetić M, Risović D. Different Protocols of Photobiomodulation Therapy of Hyposalivation. Photomed Laser Surg. 2018 Feb;36(2):78-82. doi: 10.1089/pho.2017.4325. Q2 Surgery
  7. Lončar-Brzak B, Klobučar M, Veliki-Dalić I, Sabol I, Kraljević Pavelić S, Krušlin B, Mravak-Stipetić M*. Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. Clin Oral Investig. 2018 Mar;22(2):1071-1082. doi: 10.1007/s00784-017-2190-3. Q2 Dentistry
  8. Sabol I, Milutin Gašperov N, Matovina M, Božinović K, Grubišić G, Fistonić I, Belci D, Alemany L, Džebro S, Dominis M, Šekerija M, Tous S, de Sanjosé S, Grce M*. Cervical HPV type-specific pre-vaccination prevalence and age distribution in Croatia. PLoS One. 2017 Jul 10;12(7):e0180480. doi: 10.1371/journal.pone.0180480. eCollection 2017. Q1 Multidisciplinary
  9. Szalmás A*, Tomaić V, Basukala O, Massimi P, Mittal S, Kónya J, Banks L. The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7. J Virol. 2017 Mar 13;91(7). pii: e00057-17. doi: 10.1128/JVI.00057-17. Q1 Virology
  10. Zine El Abidine A, Tomaić V, Bel Haj Rhouma R, Massimi P, Guizani I, Boubaker S, Ennaifer E, Banks L*. A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site. Virology. 2017 Jan;500:218-225. doi:10.1016/j.virol.2016.10.023. Q2 Virology
  11. Kranjec C, Tomaić V, Massimi P, Nicolaides L, Doorbar J, Banks L*. The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines. Papillomavirus Res. 2016 Dec;2:70-77. doi: 10.1016/j.pvr.2016.04.001. No Q
  12. Tomaić V*. Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers (Basel). 2016 Oct 19;8(10). pii: E95. Review. Q1 Oncology
  13. Ganti K, Massimi P, Manzo-Merino J, Tomaić V, Pim D, Playford MP, Lizano M, Roberts S, Kranjec C, Doorbar J, Banks L*. Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. PLoS Pathog. 2016 Sep 20;12(9):e1005854. doi:10.1371/journal.ppat.1005854. Q1 Virology
  14. Petrušić N, Posavac M, Sabol I, Mravak-Stipetić M*. The Effect of Tobacco Smoking on Salivation. Acta Stomatol Croat. 2015 Dec;49(4):309-15. doi: 10.15644/asc49/4/6. Gašpar M, Glavina A, Grubišić K, Sabol I, Bušić M, Mravak M; Stipetić. The Oral Cavity State in Renal Transplant Recipients. Acta Stomatol Croat. 2015 Sep;49(3):204-13. doi: 10.15644/asc49/3/2. No Q
  15. Sabol I, Smahelova J, Klozar J, Mravak-Stipetic M, Gheit T, Tommasino M, Grce M, Tachezy R*. Beta-HPV types in patients with head and neck pathology and in healthy subjects. J Clin Virol. 2016Sep;82:159-65. doi: 10.1016/j.jcv.2016.07.019. Q2 Virology
  16. Vojtechova Z, Sabol I, Salakova M, Smahelova J, Zavadil J, Turek L, Grega M, Klozar J, Prochazka B, Tachezy R*. Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones. BMC Cancer. 2016 Jul 4;16:382. doi: 10.1186/s12885-016-2430-y. Q2 Oncology
  17. Čeović R*, Desnica L, Pulanić D, Serventi Seiwerth R, Ilić I, Grce M, Mravak Stipetić M, Klepac Pulanić T, Bilić E, Bilić E, Milošević M, Vrhovac R, Nemet D, Pavletic SZ. High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croat Med J. 2016 Jun 30;57(3):229-38. Q2 Medicine
  18. Jankovic M*, Sabol I, Zmak L, Jankovic VK, Jakopovic M, Obrovac M, Ticac B, Bulat LK, Grle SP, Marekovic I, Samarzija M, van Ingen J. Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology. Int J Tuberc Lung Dis. 2016 Jul;20(7):934-40. doi: 10.5588/ijtld.15.0633. Q3 Infectious disease
  19. Dediol E*, Sabol I, Virag M, Grce M, Muller D, Manojlović S. HPV prevalence and p16INKa overexpression in non smoking non drinking oral cavity cancer patients. Oral Dis. 2016 Mar 19. doi:10.1111/odi.12476. Q2 Dentistry
  20. Vojtechova Z, Sabol I, Salakova M, Turek L, Grega M, Smahelova J, Vencalek O, Lukesova E, Klozar J, Tachezy R*. Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients' prognosis. Int J Cancer. 2016 Jan 15;138(2):386-95. doi: 10.1002/ijc.29712. Q1  Oncology
  21. Milutin Gašperov N, Sabol I, Planinić P, Grubišić G, Fistonić I, Ćorušić A, Grce M*. Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer. PLoS One. 2015 Jun 9;10(6):e0129452. doi: 10.1371/journal.pone.0129452. eCollection 2015. Q1 Multidisciplinary
  22. Zmak L*, Obrovac M, Jankovic Makek M, Sabol I, Katalinic-Jankovic V. Isolation of non-tuberculous mycobacteria among tuberculosis patients during a 5-year period in Croatia. Infect Dis (Lond). 2015 Apr;47(4):275-6. doi:10.3109/00365548.2014.987164. Q4 Infectious diseases
  23. Mravak-Stipetić M*, Lončar-Brzak B, Bakale-Hodak I, Sabol I, Seiwerth S, Majstorović M, Grce M. Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study. Sci World J. 2014;2014:746874. doi: 10.1155/2014/746874. No Q
  24. Milutin Gašperov N*, Farkas SA, Nilsson TK, Grce M. Epigenetic activation of immune genes in cervical cancer. Immunol Lett. 2014 Dec;162(2 Pt B):256-7. doi: 10.1016/j.imlet.2014.09.019. Q3 Imunology
  25. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK*. Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages. J Infect Dis. 2014 Nov 15;210(10):1600-4. doi: 10.1093/infdis/jiu310. Q1 Infectious diseases

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