dr. sc. Antonija Tomić
Bijenička cesta 54
10 000 Zagreb
Obrazovanje
2015. Zagreb, Prirodoslovno matematički fakultet Sveučilišta u Zagrebu, dr. sc.
2008. Zagreb, Prirodoslovno matematički fakultet Sveučilišta u Zagrebu, Dipl. Ing. kemije
Nagrade i priznanja
2007. Medalja Kemijskog odsjeka Prirodoslovno-matematičkog fakulteta u Zagrebu za izvrstan uspjeh u studiju kemije
Nastava
asistent na laboratorijskim vježbama iz fizikalne kemije na Prirodoslovno-matematičkom fakultetu, Sveučilište u Zagrebu, Hrvatska
Istaknute publikacije
1. Antonija Tomić; Hrvoje Brkić; Antonia Matić; Sanja Tomić. Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III. Physical chemistry chemical physics 23 (2021), 13267-13275.
2. Antonija Tomić; Gordan Horvat; Michael Ramek; Dejan Agić; Hrvoje Brkić; Sanja Tomić. New zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases. Journal of chemical information and modeling 59 (2019), 8; 3437-3453.
3. Antonija Tomić; Borislav Kovačević; Sanja Tomić. Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in the human DPP III. Physical Chemistry Chemical Physics 18 (2016), 39; 27245-27256.
4. Antonija Tomić; Sanja Tomić. Hunting the human DPP III active conformation: combined thermodynamic and QM/MM calculations. Dalton transactions 43 (2015) 15503-15514.
5. Antonija Tomić; Miguel Gonzalez; Sanja Tomić. The large scale conformational change of the human DPP III - substrate preferes the "closed" form. Journal of chemical information and modeling 52 (2012) 1583-1594.
6. Antonija Tomić; Marija Abramić; Jasminka Špoljarić; Dejan Agić; David M. Smith; Sanja Tomić. Human Dipeptidyl Peptidase III: Insights into Ligand Binding from a Combined Experimental and Computational Approach, Journal of Molecular Recognition, 24 (2011) 804-814.
Publikacije
Radovi u časopisima
Znanstveni i pregledni radovi
-
Tomić, A., Karačić, Z. & Tomić, S. (2023) Influence of Mutations of Conserved Arginines on Neuropeptide Binding in the DPP III Active Site. Molecules, 28 (4), 1976, 17 doi:10.3390/molecules28041976.
doiwww.mdpi.comfulir.irb.hr -
Karačić, Z., Šupljika, F., Tomić, A., Brkljačić, L., Tomašić Paić, A., Ćehić, M. & Tomić, S. (2022) Neuropeptides, substrates and inhibitors of human dipeptidyl peptidase III, experimental and computational study — A new substrate identified. International journal of biological macromolecules, 220, 1390-1401 doi:10.1016/j.ijbiomac.2022.09.119.
doi -
Tomić, A. & Tomić, S. (2022) Demystifying DPP III Catalyzed Peptide Hydrolysis—Computational Study of the Complete Catalytic Cycle of Human DPP III Catalyzed Tynorphin Hydrolysis. International journal of molecular sciences, 23 (3), 1858, 24 doi:10.3390/ijms23031858.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Tomić, A., Brkić, H., Matić, A. & Tomić, S. (2021) Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III. PCCP. Physical chemistry chemical physics, 23, 13267-13275 doi:10.1039/D1CP01302E.
doi -
Tomić, A., Horvat, G., Ramek, M., Agić, D., Brkić, H. & Tomić, S. (2019) New zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases. Journal of chemical information and modeling, 59 (8), 3437-3453 doi:10.1021/acs.jcim.9b00235.
doi -
Agić, D., Brkić, H., Kazazić, S., Tomić, A. & Abramić, M. (2019) Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III. Journal of Biomolecular Structure and Dynamics, 37 (14), 3596-3606 doi:10.1080/07391102.2018.1521343.
doifulir.irb.hrdoi.orgwww.tandfonline.com -
Tomin, M., Tomić, A., Kovačević, B. & Tomić, S. (2018) The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron. Croatica chemica acta, 91 (2), 187-193 doi:10.5562/cca3343.
doihrcak.srce.hrfulir.irb.hr -
Kazazić, S., Karačić, Z., Sabljić, I., Agić, D., Tomin, M., Abramić, M., Dadlez, M., Tomić, A. & Tomić, S. (2018) Conservation of the conformational dynamics and ligand binding within M49 enzyme family. RSC Advances, 8 (24), 13310-13322 doi:10.1039/c7ra13059g.
doipubs.rsc.orgpubs.rsc.orgfulir.irb.hr -
Sabljić, I., Tomin, M., Matovina, M., Sučec, I., Tomašić Paić, A., Tomić, A., Abramić, M. & Tomić, S. (2018) The first dipeptidyl peptidase III from a thermophile: Structural basis for thermal stability and reduced activity. PLoS One, 13 (2), e0192488, 25 doi:10.1371/journal.pone.0192488.
doifulir.irb.hrfulir.irb.hr -
Gundić, M., Tomić, A., Wade, R., Matovina, M., Karačić, Z., Kazazić, S. & Tomić, S. (2016) Human DPP III – Keap1 Interactions : A Combined Experimental And Computational study. Croatica chemica acta, 89 (2), 217-228 doi:10.5562/cca2916.
doihrcak.srce.hr -
Tomić, A., Kovačević, B. & Tomić, S. (2016) Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in the human DPP III. Physical Chemistry Chemical Physics, 18 (39), 27245-27256 doi:10.1039/C6CP04580D.
doi -
Tomić, A., Berynskyy, M., Wade, R. & Tomić, S. (2015) Molecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding. Molecular biosystems, 11, 3068-3080 doi:10.1039/c5mb00465a.
doi -
Tomić, A. & Tomić, S. (2014) Hunting the human DPP III active conformation : combined thermodynamic and QM/MM calculations. Dalton transactions, 43, 15503-15514 doi:10.1039/C4DT02003K.
doi -
Tomić, A., Gonzalez, M. & Tomić, S. (2012) The large scale conformational change of the human DPP III – substrate prefers the "closed" form. Journal of chemical information and modeling, 52 (6), 1583-1594 doi:10.1021/ci300141k.
doi -
Špoljarić, J., Tomić, A., Vukelić, B., Salopek-Sondi, B., Agić, D., Tomić, S. & Abramić, M. (2011) Human Dipeptidyl Peptidase III : the Role of Asn406 in Ligand Binding and Hydrolysis. Croatica chemica acta, 84 (2), 259-268 doi:10.5562/cca1808.
doihrcak.srce.hr -
Tomić, A., Abramić, M., Špoljarić, J., Agić, D., Smith, D. & Tomić, S. (2011) Human Dipeptidyl Peptidase III: Insights into Ligand Binding from a Combined Experimental and Computational Approach. Journal of molecular recognition, 24 (5), 804-814 doi:10.1002/jmr.1115.
doi -
Tomić, A. & Živković, T. (2009) On the vibrational interlacing rule in deuterated thiophenes : I. Out-of-plane vibrations. Croatica chemica acta, 82 (2), 561-566.
hrcak.srce.hr
Radovi u zbornicima skupova
Znanstveni radovi u zbornicima skupova
Tomić, S., Brkić, H., Grabar Branilović, M., Tomić, A., Branimir, B. & Mile, Š. (2013) Proteini i nukleinske kiseline u vremenu i prostoru. U: Paar, V. (ur.)Bioinformatics and biological physics: proceedings of the scientific meeting. (https://www.bib.irb.hr/689340).
Ocjenski radovi
Doktorske disertacije
-
Tomić, A. (2015) 'Primjena računalnih pristupa različitih stupnjeva složenosti u svrhu razumijevanja strukture, dinamike i aktivnosti ljudske dipeptidil-peptidaze III', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
repozitorij.pmf.unizg.hr
Članstva u profesionalnim udrugama / društvima
član Hrvatskog kemijskog društva
Član organizacijskog odbora znanstvenih susreta mladih istraživača (Znanstveni susreti 3. vrste) Instituta Ruđer Bošković 2011