2005.     Dr.sc., kemija (biokemija), Sveučilište u Zagrebu, disertacija: “Strukturne odlike nekih lipaza iz bakterija roda Streptomyces”, mentorice: dr.sc. Biserka Kojić-Prodić, IRB i dr.sc. Marija Luić, IRB

2001.     Mr.sc., kemija, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

1997.     Dipl. inž. kemije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

Voditeljica hrvatsko-austrijskog bilateralnog projekta “Native mass spectrometry in analysis of transcription factors modus operandi - Interactions of manganese metallosensors with Mn²⁺ and DNA” 2022/23.

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “The application of mass spectrometry-based „omics“ technologies to characterize products relevant for biotechnology and agriculture” 2016/17.

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “Mass spectrometry-based proteomic analysis: characterization of horseradish esterases and snake venom proteins, and mapping of Fusarium parasites” 2010/11.

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “Application of MALDI mass spectrometry in protein and intact cell analysis: characterisation of the novel SGNH-hydrolase family from Streptomyces and mapping of Fusarium parasites” 2008/09.

• Protein-protein interakcije enzima reciklirajućeg puta sinteze purina u Helicobacter pylori - PPI-HP

  20.12.2025 - 19.12.2028 | 199 927,50 EUR

  CroRISIRB

• Manganovi metalosenzori - MaMes

  01.02.2021 - 31.01.2025 | 127 036,30 EUR

  CroRIS

• Alosterički komunikacijski putevi u oligomernim enzimima - ALOKOMP/ALOCOMP

  01.01.2020 - 31.05.2024 | 120 804,30 EUR

  CroRISIRB

• ADP-ribozilacija proteina u modelnom prokariotu Streptomyces coelicolor i čovjeku

  15.10.2013 - 14.10.2015 | 1 348 064,28 HRK

  CroRISIRB

Nagrada za najbolji poster na 1st South Eastern European Workshop on Practical Approaches to Computational Biology, Opatija, 2005.

Stipendija Sveučilišta u Zagrebu 1996/97.

2008/9 – asistentica – Molekularna biofizika (Diplomski studij molekularne biologije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Greta Pifat-Mrzljak

2007/8 – asistentica – Osnove biokemije (preddiplomski studij biologije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Mirna Flögel

2007/8 – asistentica – Praktikum iz biokemije (diplomski studij kemije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Ivana Weygand-Đurašević

Voditeljica jednog doktorskog i četiri diplomska rada

Izvorni znanstveni rad

• Jelić Matošević, Zoe; Radman, Katarina; Semenić, Lana; Neves, Rui P.P.; Brajković, Mislav; Crnolatac, Ivo; Bubić, Ante; Bzowska, Agnieszka; Kutrowska, Beata Wielgus; Merunka, Dalibor et al. | The biophysical characterization of the transcription factor MntR from Mycobacterium tuberculosis and its selected mutants // International journal of biological macromolecules, 358 (2026), 151718, 18. doi: 10.1016/j.ijbiomac.2026.151718

  doiwww.sciencedirect.com

• Kolman, Robert Junior; Milčić, Nevena; Leščić Ašler, Ivana; Štefanić, Zoran; Švaco, Petra; Stepanić, Višnja; Brkljača, Zlatko; Dokli, Irena; Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja | Biocatalytic synthesis of fluorine-containing chiral azido compounds in a two-phase system // Tetrahedron letters, 178 (2026), 155982, 6. doi: 10.1016/j.tetlet.2026.155982

  doi

• Radman, Katarina; Crnolatac, Ivo; Bregović, Nikola; Jelić Matošević, Zoe; Fernandes, Pedro A.; Merunka, Dalibor; Žilić, Dijana; Piantanida, Ivo; Leščić Ašler, Ivana; Bertoša, Branimir | Conformational change induced by binding of Mn2+ ions activates SloR transcription factor in Streptococcus mutans // International journal of biological macromolecules, 290 (2025), 138828, 11. doi: 10.1016/j.ijbiomac.2024.138828

  doiwww.sciencedirect.comfulir.irb.hr

• Leščić Ašler, Ivana; Radman, Katarina; Jelić Matošević, Zoe; Bertoša, Branimir; Weiss, Victor U.; Marchetti-Deschmann, Martina | Exploring the manganese-dependent interaction between a transcription factor and its corresponding DNA: insights from gas-phase electrophoresis on a nES GEMMA instrument // Analytical & bioanalytical chemistry, 416 (2024), 24; 5377-5386. doi: 10.1007/s00216-024-05473-9

  doilink.springer.comfulir.irb.hr

• Wojtyś, Marta Ilona; Maksymiuk, Weronika; Narczyk, Marta; Bubić, Ante; Leščić Ašler, Ivana; Krzyżek, Paweł; Gościniak, Grażyna; Jagusztyn-Krynicka, Elżbieta Katarzyna; Bzowska, Agnieszka | Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains // Journal of enzyme inhibition and medicinal chemistry, 39 (2024), 1; 2372734, 16. doi: 10.1080/14756366.2024.2372734

  doifulir.irb.hr

• Mišković, Marija Zora; Wojtyś, Marta; Winiewska-Szajewska, Maria; Wielgus-Kutrowska, Beata; Matković, Marija; Domazet Jurašin, Darija; Štefanić, Zoran; Bzowska, Agnieszka; Leščić Ašler, Ivana | Location Is Everything: Influence of His-Tag Fusion Site on Properties of Adenylosuccinate Synthetase from Helicobacter pylori // International journal of molecular sciences, 25 (2024), 14; 7613, 20. doi: 10.3390/ijms25147613

  doiwww.mdpi.comfulir.irb.hr

• Radman, Katarina; Jelić Matošević, Zoe; Žilić, Dijana; Crnolatac, Ivo; Bregović, Nikola; Ilakovac Kveder, Marina; Piantanida, Ivo; Fernandes, Pedro A.; Leščić Ašler, Ivana; Bertoša, Branimir | Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn2+ ion binding // International journal of biological macromolecules, 253 (Part 8) (2023), 127572, 12. doi: 10.1016/j.ijbiomac.2023.127572

  doiwww.sciencedirect.comfulir.irb.hr

• Jelić Matošević, Zoe ; Radman, Katarina ; Loubser, Jolene ; Crnolatac, Ivo ; Piantanida, Ivo ; Cukrowski, Ignacy ; Leščić Ašler, Ivana ; Bertoša, Branimir | Structural Dynamics of the Bacillus subtilis MntR Transcription Factor Is Locked by Mn2+ Binding // International journal of molecular sciences, 24 (2023), 2; 957, 21. doi: 10.3390/ijms24020957

  doidoi.orgwww.mdpi.comfulir.irb.hr

• Bubić, Ante ; Narczyk, Marta ; Petek, Ana ; Wojtyś, Marta Ilona ; Maksymiuk, Weronika ; Wielgus-Kutrowska, Beata ; Winiewska-Szajewska, Maria ; Pavkov-Keller, Tea ; Bertoša, Branimir ; Štefanić, Zoran et al. | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site // International journal of biological macromolecules, 226 (2023), 37-50. doi: 10.1016/j.ijbiomac.2022.12.001

  doiwww.sciencedirect.comfulir.irb.hr

• Narczyk, Marta ; Wojtyś, Marta Ilona ; Leščić Ašler, Ivana ; Žinić, Biserka ; Luić, Marija ; Jagusztyn-Krynicka, Elżbieta Katarzyna ; Štefanić, Zoran ; Bzowska, Agnieszka | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium // Journal of enzyme inhibition and medicinal chemistry, 37 (2022), 1; 1083-1097. doi: 10.1080/14756366.2022.2061965

  doiwww.tandfonline.comdoi.orgfulir.irb.hr

• Wojtyś, Marta Ilona ; Jaźwiec, Radosław ; Kazazić, Saša ; Leščić Ašler, Ivana ; Knežević, Petar ; Aleksić Sabo, Verica ; Luić, Marija ; Jagusztyn- Krynicka, Elżbieta Katarzyna ; Bzowska, Agnieszka | A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori // Applied microbiology and biotechnology, 105 (2021), 7949-7967. doi: 10.1007/s00253-021-11510-9

  doilink.springer.comdoi.orgfulir.irb.hr

• Narczyk, Marta ; Bertoša, Branimir ; Papa, Lucija ; Vuković, Vedran ; Leščić Ašler, Ivana ; Wielgus- Kutrowska, Beata ; Bzowska, Agnieszka ; Luić, Marija ; Štefanić, Zoran | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features // The FEBS journal, 285 (2018), 7; 1305-1325. doi: 10.1111/febs.14403

  doifebs.onlinelibrary.wiley.com

• Bubić, Ante ; Mrnjavac, Natalia ; Stuparević, Igor ; Łyczek, Marta ; Wielgus-Kutrowska, Beata ; Bzowska, Agnieszka ; Luić, Marija ; Leščić Ašler, Ivana | In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori // Journal of enzyme inhibition and medicinal chemistry, 33 (2018), 1; 1405-1414. doi: 10.1080/14756366.2018.1506773

  doiwww.tandfonline.comfulir.irb.hr

• Bošnjaković, Marta; Leščić Ašler, Ivana; Štefanić, Zoran | The Role of Phosphate Binding in Purine Nucleoside Phosphorylase of Helicobacter pylori // Croatica chemica acta, 91 (2018), 2; 171-175. doi: 10.5562/cca3335

  doihrcak.srce.hrhrcak.srce.hrfulir.irb.hr

• Leščić Ašler, Ivana ; Štefanić, Zoran ; Maršavelski, Aleksandra ; Vianello, Robert ; Kojić-Prodić, Biserka | Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus // Acs chemical biology, 12 (2017), 7; 1928-1936. doi: 10.1021/acschembio.6b01140

  doipubs.acs.org

• Štefanić, Zoran ; Mikleušević, Goran ; Luić, Marija ; Bzowska, Agnieszka ; Leščić Ašler, Ivana | Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori // International journal of biological macromolecules, 101 (2017), 518-526. doi: 10.1016/j.ijbiomac.2017.03.101

  doiwww.sciencedirect.comdoi.org

• Leščić Ašler, Ivana ; Peharec Štefanić, Petra ; Balen, Biljana ; Allmaier, Günter ; Marchetti- Deschmann, Martina ; Kojić-Prodić, Biserka | Horseradish esterases: detection, purification and identification // Plant cell, tissue and organ culture, 130 (2017), 1; 13-24. doi: 10.1007/s11240-017-1200-0

  doilink.springer.com

• Bertoša, Branimir ; Mikleušević, Goran ; Wielgus-Kutrowska, Beata ; Narczyk, Marta ; Hajnić, Matea ; Leščić Ašler, Ivana ; Tomić, Sanja ; Luić, Marija ; Bzowska, Agnieszka | Homooligomerization is needed for stability: a molecular modelling and solution study of E. coli purine nucleoside phosphorylase // The FEBS journal, 281 (2014), 7; 1860-1871. doi: 10.1111/febs.12746

  doi

• Leščić Ašler, Ivana ; Kovačić, Filip ; Marchetti-Deschmann, Martina ; Allmaier, Günter ; Štefanić, Zoran ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus with 3, 4-dichloroisocoumarin // Journal of enzyme inhibition and medicinal chemistry, 28 (2013), 5; 1094-1104. doi: 10.3109/14756366.2012.716834

  doiwww.pubfacts.com

• Leščić Ašler, Ivana ; Pigac, Jasenka ; Vujaklija, Dušica ; Luić, Marija ; Štefanić, Zoran | Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3, 4- dichloroisocoumarin // Acta crystallographica. Section F, Structural biology and crystallization communications, 67 (2011), 11; 1378-1381. doi: 10.1107/S1744309111032222

  doijournals.iucr.orgonlinelibrary.wiley.comdoi.org

• Leščić Ašler, Ivana ; Ivić, Nives ; Kovačić, Filip ; Schell, Sabrina ; Knorr, Janina ; Krauss, Ulrich ; Wilhelm, Susanne ; Kojić-Prodić, Biserka ; Jaeger, Karl-Erich | Probing Enzyme Promiscuity of SGNH Hydrolases // ChemBioChem : a European journal of chemical biology, 11 (2010), 15; 2158-2167. doi: 10.1002/cbic.201000398

  doionlinelibrary.wiley.com

• Luić, Marija ; Štefanić, Zoran ; Ceilinger, Igor ; Hodošček, Milan ; Janežić, Dušanka ; Lenac, Tihana ; Leščić Ašler, Ivana ; Šepac, Dragan ; Tomić, Sanja | Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification // The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 112 (2008), 16; 4876-4883. doi: 10.1021/jp077717u

  doipubs.acs.org

• Leščić Ašler, Ivana ; Zehl, Martin ; Kovačić, Filip ; Müller, Roland ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Mass spectrometric evidence of covalently-bound tetrahydrolipstatin at the catalytic serine of Streptomyces rimosus lipase // Biochimica et biophysica acta. G, General subjects, 1770 (2007), 2; 163-170-x

  dx.doi.org

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Rizzi, Andreas ; Kojić-Prodić, Biserka ; Allmaier, Günter | Characterization of covalently inhibited extracellular lipase from Streptomyces rimosus by matrix-assisted laser desorption/ionization time-of-flight and matrix-assisted laser desorption/ionization quadrupole ion trap reflectron time-of-flight mass spect // Journal of mass spectrometry, 39 (2004), 12; 1474-1483. doi: 10.1002/jms.750

  doionlinelibrary.wiley.comdoi.org

• Leščić, Ivana ; Zehl, Martin ; Müller, Roland ; Vukelić, Bojana ; Abramić, Marija ; Pigac, Jasenka ; Allmaier, Günter ; Kojić-Prodić, Biserka | Structural characterization of extracellular lipase from Streptomyces rimosus: Assignment of disulfide bridges pattern by mass spectrometry // Biological chemistry, 385 (2004), 12; 1147-1156-x

• Vujaklija, Dušica ; Abramić, Marija ; Leščić, Ivana ; Maršić, Tereza ; Pigac, Jasenka. | Streptomyces rimosus GDS(L) lipase: production, heterologous overexpression and structure-stability relationship // Food technology and biotechnology, 41 (2003), 1; 89-94-x

• Vujaklija, Dušica ; Schroeder, Werner ; Abramić, Marija ; Zou, Peijian ; Leščić, Ivana ; Franke, Peter ; Pigac, Jasenka | A novel streptomycete lipase: cloning, sequencing and high-level expression of the Streptomyces rimosus GDS(L)-lipase gene // Archives of microbiology, 178 (2002), 2; 124-130-x

• Luić, Marija ; Tomić, Sanja ; Leščić, Ivana ; Ljubović, Edina ; Šepac, Dragan ; Šunjić, Vitomir ; Vitale, Ljubinka ; Saenger, Wolfram ; Kojić-Prodić, Biserka | Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study. // European journal of biochemistry, 268 (2001), 14; 3964-3973-x

• Leščić, Ivana ; Vukelić, Bojana ; Majerić-Elenkov, Maja ; Saenger, Wolfram ; Abramić, Marija | Substrate specifity and effects of water-miscible solvents on the activity and stability of extracellular lipase from Streptomyces rimosus // Enzyme and microbial technology, 29 (2001), 548-553-x

• Abramić, Marija ; Leščić, Ivana ; Korica, Tamara ; Vitale, Ljubinka ; Saenger, Wolfram ; Pigac, Jasenka | Purification and properties of extracellular lipase from Streptomyces rimosus // Enzyme and microbial technology, 25 (1999), 6; 522-529-x

Kratko priopćenje

• Luić, Marija ; Papa, Lucija ; Štefanić, Zoran ; Leščić Ašler, Ivana ; Knežević, Petar ; Bzowska, Agnieszka | H. pylori purine nucleoside phosphorylase: catalytic features and three-dimensional structure // Acta crystallographica. Section A, Foundations and advances, 73 (2017), a2; C160-C160. doi: 10.1107/s205327331709413x

  doijournals.iucr.org

Uvodnik

• Leščić Ašler, Ivana | Special Issue “Mechanism of Enzyme Catalysis: When Structure Meets Function” // International journal of molecular sciences, 27 (2026), 4; 1887, 3. doi: 10.3390/ijms27041887

  doiwww.mdpi.comwww.mdpi.comfulir.irb.hrfulir.irb.hr

Sažetak izlaganja sa skupa

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Metal-Driven Allosteric Regulation of the MtsR Metalloregulator: Mechanistic Insights into Activation and DNA Binding // Computational Chemistry Day 2026 : Book of Abstracts / Babić, Darko (ur.). | Zagreb: Institut Ruđer Bošković, 2026. str. 34-34

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Structural and dynamical changes of the Streptococcus pyogenes transcriptional regulator MtsR induced by Mn²⁺ binding // RBC2026 Regional Biophysics Conference 2026 Book of Abstracts / Radotić Hadži-Manić, Ksenija; Mojović, Miloš (ur.). | Beograd: Srpska akademija nauka i umetnosti, 2026. str. 21-21

• Leščić Ašler, Ivana; Radman, Katarina; Bertoša, Branimir | Exploring the interactions of manganese-dependent transcription regulators SloR and ScaR with DNA - an experimental study // FEBS3+ Meeting: Exploring Molecular Frontiers / Dulić, Morana; Sinčić, Nino; Stuparević, Igor (ur.). | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju, 2024. str. 131-131

• Leščić Ašler, Ivana | Mass Spectrometry Contribution to the Study Of Extracellular Lipase from Bacterium Streptomyces rimosus // 2nd Workshop on Mass Spectrometry in Life Sciences : Book of abstracts / Novak, Ruđer ; Močibob, Marko ; Dulić, Morana et al. (ur.). | Zagreb: University of Zagreb Faculty of Science, 2024. str. 34-34

  repozitorij.pmf.unizg.hr

• Mišković, Marija Zora; Wojtys, Marta; Bzowska, Agnieszka; Štefanić, Zoran; Leščić Ašler, Ivana | Location is everything: Influence of His-tag fusion site on properties of adenylosuccinate synthetase from Helicobacter pylori // Hot Topics in Contemporary Crystallography 6 (HTCC 6) - Advanced macromolecular crystallography workshop: Programme Book / Bjelopetrović, Alen (ur.). | Zagreb: Croatian Association of Crystallographers, 2024. str. 60-60

• Radman, Katarina ; Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Crnolatac, Ivo ; Piantanida, Ivo ; Bertoša, Branimir | Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii) // 28th Croatian Meeting of Chemists and Chemical Engineers (28HSKIKI): Book of Abstracts / Rogošić, Marko (ur.). | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 119-119

  www.hdki.hr

• Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Radman, Katarina ; Piantanida, Ivo ; Crnolatac, Ivo ; Bertoša, Branimir | Influence of engineered disulfide bridge on properties of metal sensing transcription factor MntR from Bacillus subtilis // HDBMB22 From Science to Knowledge : Book of Abstracts. | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2022. str. 100-100

  congress2022.hdbmb.hr

• Bertoša, Branmir ; Jelić Matošević, Zoe ; Brajković, Mislav ; Leščić Ašler, Ivana ; Neves, Rui P. P. ; Fernandes, Pedro A. ; Cukrowski, Ignacy | MNTR PROTEINS AS MANGANESE METALLOSENZORS IN BACILUS SUBTILUS AND MYCOBACTERIUM TUBERCULOSIS // EuChems Chemistry Congress. | 2022. str. 536-536

• Bubić, Ante ; Štefanić, Zoran ; Bertoša, Branimir ; Leščić Ašler, Ivana | Adenylosuccinate Synthetase from Helicobacter pylori: Characterization of Active Site Using X- ray Diffraction and Molecular Dynamics Simulations // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 194-194

  27hskiki.hkd.hr

• Bubić, Ante ; Bertoša, Branimir ; Leščić Ašler, Ivana ; Luić, Marija | Experimental and in silico characterization of adenylosuccinate synthetase from patogen Helicobacter pylori // Knjiga sažetaka. | 2019. str. 35-35

• Bubić, Ante ; Bertoša, Branimir ; Lešćić Ašler, Ivana ; Luić, Marija | Computational and experimental characterization of adenylosuccinate synthetase from Helicobacter pylori // 26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 27-27

  www.hdki.hr

• Bubić, Ante ; Leščić Ašler, Ivana ; Bertoša, Branimir ; Luić, Marija | Characterization of adenylosuccinate synthetase from Helicobacter pylori using computational and experimental approach // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka. | Zagreb, 2019. str. 39-40

  www.pmf.unizg.hr

• Bertoša, Branimir ; Kazizić, Saša ; Mikleušević, Goran ; Štefanić, Zoran ; Narczyk, Marta ; Wielgus- Kutrowska, Beata ; Hajnić, Matea ; Leščić Ašler, Ivana ; Tomić, Sanja ; Tarnowski, Krzysztof et al. | Role of subunit-subunit interactions in the catalysis conducted by hexameric purine nucleoside phosphorylase. | 2015. str. 1-1

• Luić, Marija ; Gucunski, Karolina ; Leščić Ašler, Ivana ; Štefanić, Zoran | Structural investigations of purine nucleoside phosphorylase from Helicobacter pylori II // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 204-204

• Štefanić, Zoran ; Leščić Ašler, Ivana ; Mikleušević, Goran ; Luić, Marija | Structural investigations of purine nucleoside phosphorylase from Helicobacter pylori I // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 234-x

• Gucunski, Karolina ; Leščić Ašler, Ivana ; Luić, Marija | Purine nucleoside phosphorylase from bacterium Helicobacter pylori strain 26695: Cloning, Expression, Purification, Characterisation and Crystallisation // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 214-x

• Leščić Ašler, Ivana ; Štefanić, Zoran ; Luić, Marija ; Kojić-Prodić, Biserka | Crystal structure of Streptomyces rimosus extracellular lipase // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 206-x

• Leščić Ašler, Ivana ; Peharec Štefanić, Petra ; Balen, Biljana ; Marchetti-Deschmann, Martina ; Krsnik-Rasol, Marijana ; Kojić-Prodić, Biserka ; Allmaier, Günter | Identification of esterase isoenzymes related to cell differentiation in Armoracia lapathifolia Gilib. tissue culture by gel electrophoresis and mass spectrometry techniques // FEBS 3+ Meeting Book of Abstracts. | Rijeka: Hrvatsko Društvo za Biotehnologiju, 2012. str. 239-x

• Narczyk, Marta ; Wielgus-Kutrowska, Beata ; Mikleušević, Goran ; Leščić Ašler, Ivana ; Luić, Marija ; Bzowska, Agnieszka | Escherichia coli purine nucleoside phosphorylase validation of catalytic mechanism // Tenth International Summer School on Biophysics: Supramolecular Structure and Function, Book of Abstracts. | Zagreb: Institut Ruđer Bošković, 2009. str. 135-135

• Mikleušević, Goran ; Leščić Ašler, Ivana ; Luić, Marija ; Wielgus-Kutrowska, Beata ; Narczyk, Marta ; Bzowska, Agnieszka | Purin nukleozid fosforilaza iz bakterije Escherichia coli: Provjera modela katalitičkog djelovanja // 50 godina molekularne biologije u Hrvatskoj, Zbornik sažetaka. | Zagreb: Institut Ruđer Bošković, 2008. str. 38-38

• Mikleušević, Goran ; Leščić Ašler, Ivana ; Salopek-Sondi, Branka ; Narczyk, Marta ; Luić, Marija ; Bzowska, Agnieszka | How Escherichia coli purine nucleoside phosphorylase active site mutants help in understanding catalytic mechanism // 4th Croatian Congress of Microbiology with International Participation Book of Abstracts. | Zagreb: Hrvatsko mikrobiološko društvo, 2008. str. 67-67

• Peharec, Petra ; Leščić-Ašler, Ivana ; Balen, Biljana ; Kojić-Prodić, Biserka ; Krsnik-Rasol, Marijana | Aktivnost i izoforme esteraze povezane sa staničnom diferencijacijom u kulturi tkiva hrena Armoracia lapathifolia Gilib. // 50 godina molekularne biologije u Hrvatskoj. | Zagreb: Institut Ruđer Bošković, 2008. str. 71-71

• Leščić Ašler, Ivana ; Ivić, Nives, Kojić-Prodić, Biserka | How promiscuous are SGNH-hydrolases? // HDBMB2008 Book of Abstracts. | Osijek: Hrvatsko Društvo za Biotehnologiju, 2008. str. 100-100

• Leščić Ašler, Ivana ; Ivić, Nives ; Kojić-Prodić, Biserka | How promiscuous are SGNH-hydrolases? // 4th Central European Conference Chemistry towards Biology Book of Abstracts. | Budimpešta: Hungarian Chemical Society, 2008. str. 107-107

• Leščić Ašler, Ivana | Bioinformatic analysis of lipases from bacteria of genus Streptomyces // European Biomarkers Summit and Proteomics Europe. | Acton Sudbury, 2007. str. --x

• Leščić Ašler, Ivana ; Zehl, Martin ; Kovačić, Filip ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Guenter | Characterization of Streptomyces rimosus lipase complexes with inhibitors by kinetics and mass spectrometry // 2nd Summer Course on Mass Spectrometry in Biotechnology and Medicine Book of Abstracts. | Münster, 2007. str. 62-x

• Zehl, Martin ; Müller, Roland ; Leščić, Ivana ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Günter | CGE-on-theChip (Bioanalyzer) and MALDI mass spectrometry: tools for the characterization of Streptomyces lipase-inhibitor complexes // 25th International Symposium & Exhibit on the Separation of Proteins, Peptides & Polynucleotides Book of Abstracts. | 2005

• Leščić Ašler, Ivana | Bioinformatic analysis of lipases from bacteria of genus Streptomyces // 1st South Eastern European Workshop on Practical Approaches to Computational Biology Book of Abstracts. | Zagreb: Institut Ruđer Bošković, 2005. str. 52-x

• Leščić Ašler, Ivana ; Kovačić, Filip ; Kojić-Prodić, Biserka | 3D-Structure features of novel GDSL-enzyme by bioinformatic methods and mass spectrometry // FEBS Journal 272 Suppl. 1. | 2005. str. 110-110-x

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Rizzi, Andreas ; Kojić-Prodić, Biserka ; Allmaier, Günter | Characterization of an extracellular lipase from Streptomyces rimosus by MALDI-TOF and MALDI-IT/RTOF multistage mass spectrometry: assignment of disulfide bridge pattern and localization of the active site serine // 6. Igler MS Tage book of abstracts. | Innsbruck, 2005

• Vujaklija, Dusica ; Leščić, Ivana ; Abramic, Marija ; Kojić-Prodić, Biserka ; Pigac, Jasenka | STREPTOMYCETES AS PRODUCERS OF LIPOLYTIC ENZYMES. | 2005. str. 173-174-x

• Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Elements of Streptomyces rimosus extracellular lipase stability : Assignment of disulfide bridges. | Bratislava, 2004

• Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Elements of Streptomyces rimosus extracellular lipase stability : Assignment of disulfide bridges // Zbornik sažetaka postera znanstvenih novaka, prikazanih u inozemstvu 2002., 2003. i 2004. godine / Prvi kongres hrvatskih znanstvenika iz domovine i inozemstva, Zagreb-Vukovar, 15. -19. studenoga 2004, I. dio: prirodne, tehničke i biotehničke znanosti. | Zagreb, 2004. str. 101-101-x

• Leščić, Ivana ; Kovačić, Filip ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Luić, Marija ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus by three distinctive serine specific agents // 1st Workshop Enzyme Technology and Biocatalysis Book of Abstracts. | Graz, 2004. str. 5-5-x

• Vujaklija, Dušica ; Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Jasenka, Pigac | A novel family of bacterial lipases // Third Croatian Congress of Microbiology with International with International Participation. | Zagreb: Hrvatsko mikrobiološko društvo, 2004. str. 147-147

• Leščić, Ivana ; Kovačić, Filip ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Luić, Marija ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus by three distinctive serine specific agents // 2nd Central European Conference Chemistry towards Biology : Book of Abstracts. | Seggau, 2004

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Günter | MALDI TOF- and MALDI low energy CID multistage MS-based characterization of an extracellular lipase from Streptomyces rimosus before and after covalent inhibition by 3, 4-dichloroisocoumarin. | Tokaj, 2004

• Pigac, Jasenka ; Abramić, Marija ; Leščić, Ivana ; Kojić-Prodić, Biserka ; Vujaklija, Dušica | The gene encoding for GDS(L) lipase was found in Streptomyces rimosus // 45 GODINA MOLEKULARNE BIOLOGIJE U HRVATSKOJ 50 GODINA DVOSTRUKE UZVOJNICE. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 39-39-x

• Vujaklija, Dušica ; Abramić, Marija ; Leščić, Ivana ; Pigac, Jasenka | The third lipolytic-family in Streptomyces, represented by the novel GDS(L) lipase from S. rimosus // Power of microbes in industry and environment. | Zagreb: Prehrambeno-biotehnološki fakultet Sveučilišta u Zagrebu, 2002. str. 16-16-x

• Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka ; Abramić, Marija | Protein sequence analysis of Streptomyces rimosus extracellular lipase // 1st Croatian Congress on Molecular Life Sciences with International Participation, Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002

• Luić, Marija ; Leščić, Ivana ; Lenac, Tihana ; Kojić-Prodić, Biserka | Molecular basis of enantioselectivity of Burkholderia cepacia lipase toward secondary alcohols // 1st Central European Conference "Chemistry towards Biology", Book of abstracts. | Ljubljana, 2002. str. 96-96-x

• Abramić, Marija ; Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka | Extracellular lipase from streptomyces rimosus: an unusual bacterial lipolytic enzyme // 1st Central European Conference "Chemistry towards Biology" - Book of Abstracts. | Ljubljana: Slovenian Chemical Society, 2002. str. 38-38-x

• Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka ; Abramić, Marija | Extracellular lipase from bacterium Streptomyces rimosus: cloning, expression and purification for crystallization // 9th International Conference on the Crystallization of Biological Macromolecules - Book of Abstracts. | Jena, 2002

• Abramić, Marija ; Leščić, Ivana ; Luić, Marija ; Kojić-Prodić, Biserka ; Pigac, Jasenka ; Vujaklija, Duška | A novel type of extracellular lipase from Streptomyces rimosus: isolation, (bio)chemical characterisation, cloning and crystallisation // Applied Biocatalysis. | Zürich: ETH Zurich, 2002. str. 25-25-x

• Tomić, Sanja ; Luić, Marija ; Šepac, Dragan ; Leščić, Ivana ; Ljubović, Edina ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Molecular modeling of the complex of 1-phenoxy-2- butanol with acetyl -pseudomonas cepacia lipase (PCL), and its p-transition state analog in comparison with the experimental results // Rational approaches to drug design: Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships. | Düsseldorf: Prous Science, Barcelona, 2001. str. 69-73

• Leščić, Ivana ; Vukelić, Bojana ; Majerić-Elenkov, Maja ; Abramić, Marija | Substratna specifičnost izvanstanične lipaze bakterije Streptomyces rimosus // Sažeci = Abstracts / XVII. hrvatski skup kemičara i kemijskih inženjera, Osijek, 10.-13. lipnja 2001.. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2001. str. 108-x

• Leščić, Ivana ; Luić, Marija ; Kojić-Prodić, Biserka | The crystal structure of Pseudomonas cepacia lipase with bound transition state analog // Seventh International Summer School on Biophysics: Supramolecular Structure and Function. | 2000. str. 103-103-x

• Leščić, Ivana ; Vitale, Ljubinka ; Abramić, Marija | Substrate specificity and regioselectivity of extracellular lipase from Streptomyces rimosus. // HB 2000; Kongres hrvatskih biokemičara i molekularnih biologa. Knjiga sažetaka.. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 87-87-x

• Luić, Marija ; Leščić, Ivana ; Kojić-Prodić, Biserka | Crystal Structure of the Complex of Pseudomonas Cepacia Lipase with Transition State Analog // Ninth Slovenian-Croatian Crystallographic Meeting : Book of Abstracts and Programme. | Ljubljana: Slovenian crystallographic society ; Croatian crystallographic association, 2000. str. 23-23

• Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schröder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | "Structure is function": A contribution to understanding enzymatic activity of bacterial lipases. // Kongres hrvatskih biokemičara i molekularnih biologa, HB 2000. Knjiga sažetaka.. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 46-46-x

• Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schroeder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | A contribution to understanding of enzymatic activity of bacterial lipases. // Workshop of Challenges in Crystallography of Macromolecular Assemblies. | Trst: Synchrotron Trieste, 2000. str. 24-24-x

• Leščić, Ivana ; Pigac, Jasenka ; Korica, Tamara ; Vitale, Ljubinka ; Abramić, Marija | Extracellular lipase from bacterium Streptomyces rimosus // HB98 - Godišnji sastanak hrvatskih biokemičara. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 1998. str. 63-63-x

Sažetak izlaganja sa skupa

• Leščić Ašler, Ivana; Steinberger, Stephanie; Weiss, Victor U.; Jelić Matošević, Zoe; Radman, Katarina; Bertoša, Branimir | Protein dynamics and DNA binding of native metal-sensing transcription factor MntR from Bacillus subtilis and its D8C/E99C double mutant // FEBS Open Bio, 13, S2, 2023. str. 176-176

• Bubić, Ante ; Petek, Ana ; Štefanić, Zoran ; Leščić Ašler, Ivana | Biochemical characterization of His6-tagged adenylosuccinate synthetase from Helicobacter pylori: first step towards design of new inhibitors // FEBS Open Bio, 12, S1, 2022. str. 235-235

  febs.onlinelibrary.wiley.com

Neobjavljeni prilog sa skupa

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Metal-Driven Allosteric Regulation of the MtsR Metalloregulator: Mechanistic Insights into Activation and DNA Binding // Computational Chemistry Day 2026 | Zagreb, Hrvatska, 09.05.2026-09.05.2026

• Radman, Katarina; Leščić Ašler, Ivana; Bregović, Nikola; Crnolatac, Ivo; Piantanida, Ivo; Ilakovac Kveder, Marina; Žilić, Dijana; Bertoša, Branimir | Structural Changes in the Metalloregulatory Protein ScaR (Streptococcus gordonii) Influenced by Mn 2+ Ion Binding // EMBO workshop: ImmunoBiophysics #2 - From fundamental physics to understanding the immune response | Les Houches, Francuska, 09.04.2023-14.04.2023

• Narczyk, M. ; Leščić Ašler, Ivana ; Wojtyś, M. ; Štefanić, Zoran ; Luić, Marija ; Jagusztyn- Krynicka, K. ; Bzowska, A. | Inhibition of Helicobacter pylori purine nucleoside phosphorylase and bacteria cell cultures with 2-chloro-6-substituted purines // 45th FEBS 2020 Congress Molecules of Life: Towards New Horizons | Ljubljana, Slovenija, 03.07.2021-08.07.2021

• Bubić, Ante ; Narczyk, M. ; Maksymiuk, W. ; Štefanić, Zoran ; Bzowska, A. ; Leščić Ašler, Ivana | Conformational changes in adenylosuccinate synthetase from Helicobacter pylori upon ligand binding // EMBL Conference Bringing molecular structure to life: 50 years of the PDB | virtual, 20.10.2021-22.10.2021

• Bubić, Ante ; Leščić Ašler, Ivana ; Bertoša, Branimir ; Luić, Marija | Adenylosuccinate synthetase from pathogen Helicobacter pylori // Structural Bioinformatics | Hinxton, Ujedinjeno Kraljevstvo, 16.09.2019-20.09.2019

• Bubić, Ante ; Leščić Ašler, Ivana ; Luić, Marija | Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori // FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice | Nové Hrady, Češka Republika, 24.06.2018-01.07.2018

• Leščić Ašler, Ivana ; Mrnjavac, Natalia ; Stuparević, Igor ; Štefanić, Zoran ; Luić, Marija | Adenylosuccinate synthetase from bacterium Helicobacter pylori strain 26695: purification and characterization // Proteins in action : biophysical techniques for protein research | České Budějovice, Češka Republika, 26.06.2017-28.06.2017

  www.xray.cz

• Leščić Ašler, Ivana; Štefanić, Zoran; Luić, Marija | Insights into catalytic mechanism of an enzyme // XVI International Conference on Science, Arts and Culture, INTERNATIONAL CONFERENCE ON SESAME In honour of Paolo Budinich | Veli Lošinj, Hrvatska, 29.08.2016-02.09.2016

  indico.cern.ch

• Leščić Ašler, Ivana ; Marchetti-Deschmann, Martina ; Kojić-Prodić, Biserka ; Allmaier, Günter | Mass spectrometric analysis of interaction of Streptomyces rimosus lipase with 3, 4-dichloroisocoumarin // Advances in Metabolic Profiling & Mass Spec Europe | Dublin, Irska, 08.11.2011-09.11.2011

• Kovačić, Filip ; Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Determination of the catalytically active serine of extracellular lipase from Streptomyces rimosus by inhibition studies and mass spectrometry // Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB2004 | Hrvatska, 30.09.2004-02.10.2004

• Leščić, Ivana ; Kovačić, Filip ; Kojić-Prodić, Biserka | Strukturne osobine izvanstanične lipaze bakterije Streptomyces rimosus predviđene iz proteinske sekvence // Bioinformatika IRB - 2004 | Zagreb, Hrvatska, 10.12.2004-10.12.2004

  www.irb.hr

• Leščić, Ivana | Ghosts of enzyme past, present and future: Extracellular lipase from bacterium Streptomyces rimosus // EMBO Bioinformatics Course | Maynooth, Irska, 28.04.2003-03.05.2003

Diplomski rad (sveučilišni)

• Mišković, Marija Zora | Utjecaj položaja His6 privjeska na svojstva proteina, primjer adenilosukcinat-sintetaze iz bakterije Helicobacter pylori; O lijekovima kroz predtercijarnu nastavu kemije / Leščić Ašler, Ivana; Mrvoš Sermek, Draginja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2025

  repozitorij.pmf.unizg.hr

• Srnec, Karla | Utjecaj iona metala na aktivnost adenilosukcinat- sintetaze iz bakterije Helicobacter pylori ; Priča o želatini i voću / Leščić Ašler, Ivana ; Mrvoš-Sermek, Draginja (mentor); Bubić, Ante (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2021

  repozitorij.pmf.unizg.hr

• Petek, Ana | Utjecaj afinitetnog privjeska na svojstva adenilosukcinat-sintetaze iz bakterije Helicobacter pylori / Leščić Ašler, Ivana (mentor); Bubić, Ante (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2020

  urn.nsk.hrzir.nsk.hr

• Gucunski, Karolina | Purinska nukleozidna fosforilaza iz soja 26695 bakterije Helicobacter pylori: Ekspresija, pročišćavanje i karakterizacija / Luić, Marija (mentor); Leščić Ašler, Ivana (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2018

• Kovačić, Filip | Inhibicija izvanstanične lipaze bakterije Streptomyces rimosus / Kojić-Prodić, Biserka ; Weygand-Đurašević, Ivana (mentor); Leščić, Ivana (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2005

• Leščić, Ivana | Ekstracelularna lipaza bakterije Streptomyces rimosus: izolacija i karakterizacija / Weygand-Đurašević, Ivana ; Abramić, Marija (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1997

Magistarski rad (znanstveni)

• Leščić, Ivana | Bakterijske lipaze: biokemijska i strukturna karakterizacija / Abramić, Marija ; Kojić-Prodić, Biserka (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2001

Doktorski rad

• Radman, Katarina | Mehanizmi interakcija transkripcijskih faktora SloR iz Streptococcus mutans i ScaR iz Streptococcus gordonii s ionima mangana(II) i DNA / Leščić Ašler, Ivana; Bertoša, Branimir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2025

  repozitorij.pmf.unizg.hr

• Bubić, Ante | Biokemijska karakterizacija adenilosukcinat- sintetaze bakterije Helicobacter pylori eksperimentalnim i računalnim metodama / Bertoša, Branimir ; Leščić Ašler, Ivana (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2021

  repozitorij.pmf.unizg.hr

• Leščić Ašler, Ivana | Strukturne odlike nekih lipaza iz bakterija roda Streptomyces / Kojić-Prodić, Biserka ; Luić, Marija (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2005

članica Hrvatskog Kemijskog Društva

članica Hrvatskog Društva za Biokemiju i Molekularnu Biologiju

članica Hrvatskog Društva za Proteomiku