- Osnovna i srednja škola (Gimnazija M.A. Reljković) završena u Vinkovcima, maturirao 1987. god.;
- 1994. god. diplomirao biologiju, smjer dipl. inž. biologije-ekologije na Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu;
- 1998. god. magisterij iz prirodnih znanosti, polje biologija, grana toksikologija, na Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu;
- 1999. god. doktorat iz prirodnih znanosti, polje biologija, grana ekotoksikologija, na Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu.
Aktualni projekti:
- Ecotoxicological significance of ABC transport proteins in aquatic organisms,(2008-2013) – Project supported by the Ministry of Science Education and Sports – principal investigator;
- EDA-EMERGE - Innovative biodiagnosis meets chemical structure elucidation – Novel tools in effect directed analysis to support the identification and monitoring of emerging toxicants on a European scale,(2011-2013) – Marie Curie Initial Training Networks (ITN) project - leader of the project workgroup.
- B. Raspor, T. Smital – kolegij Biološki učinci metala i organskih zagađivala na morske organizme; poslijediplomski doktorski studij iz Oceanologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu;
- T. Smital – kolegij Ekotoksikologija; poslijediplomski doktorski studij iz Zaštite prirode i okoliša, Sveučilište u Osijeku;
- G. Klobučar, M. Pavlica, V. Garaj-Vrhovac, T. Smital – kolegij Biomarkeri u biomonitoringu zagađenja okoliša, poslijediplomski doktorski studij iz Biologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu.
Smital, T. & Ahel, M. (2015) Ecotoxicological characterization of the Sava River – biomarker responses and biological assays. U: Milačić, R., Ščančar, J. & Paunović, M. (ur.) The Sava River. Berlin, Heidelberg, Springer-Verlag, str. 177-200.
Smital, T. (2008) Acute and Chronic Effects of Emerging Contaminants. U: Barcelo, D. & Petrovic, M. (ur.) Emerging Contaminants from Industrial and Municipal Waste - Occurrence, Analysis and Effects. Berlin, Springer-Verlag, str. 154-193.
Epel, D. & Smital, T. (2001) Multidrug-multixenobiotic transporters and their significance with respect to environmental levels of pharmaceuticals and personal care products. U: Daughton, C. & Jones-Lepp, T. (ur.) Pharmaceuticals and personal care products in the environment - scientific and regulatory issues. Washington, DC, American Chemical Society and Oxford University Press, str. 244-263.
Dragojević, J., Mihaljević, I., Popović, M. & Smital, T. (2019) Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 236, 110309, 11 doi:10.1016/j.cbpb.2019.110309.
doiKostanjevečki, P., Petrić, I., Lončar, J., Smital, T., Ahel, M. & Terzić, S. (2019) Aerobic biodegradation of tramadol by pre- adapted activated sludge culture: Cometabolic transformations and bacterial community changes during enrichment. Science of the total environment, 687, 858-866 doi:.org/10.1016/j.scitotenv.2019.06.118.
doiBašica, B., Mihaljević, I., Maraković, N., Kovačević, R. & Smital, T. (2019) Molecular characterization of zebrafish Gstr1, the only member of teleost-specific glutathione S- transferase class. Aquatic toxicology, 208, 196-207 doi:10.1016/j.aquatox.2019.01.005.
doiKostanjevečki, P., Sviličić Petrić, I., Lončar, J., Smital, T., Ahel, M. & Terzić, S. (2019) Biodegradation study of methadone by adapted activated sludge: Elimination kinetics, transformation products and ecotoxicological evaluation. Chemosphere, 214, 719-728 doi:10.1016/j.chemosphere.2018.09.153.
doiKaraica, D., Breljak, D., Lončar, J., Lovrić, M., Micek, V., Vrhovac Madunić, I., Brzica, H., Herak-Kramberger, C., Ivković Dupor, J., Ljubojević, M., Smital, T., Vogrinc, Ž., Burckhardt, G., Burckhardt, B. & Sabolić, I. (2018) Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys. Arhiv za higijenu rada i toksikologiju, 69 (4), 286-303 doi:10.2478/aiht-2018-69-3157.
doihrcak.srce.hrTerzic, S., Udikovic-Kolic, N., Jurina, T., Krizman-Matasic, I., Senta, I., Mihaljevic, I., Loncar, J., Smital, Tvrtko & Ahel, M. (2018) Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation. Journal of hazardous materials, 349, 143-152 doi:10.1016/j.jhazmat.2018.01.055.
doiLončar, J. & Smital, T. (2018) Interaction of environmental contaminants with zebrafish multidrug and toxin extrusion protein 7 (Mate7/Slc47a7). Aquatic toxicology, 205, 193-203 doi:10.1016/j.aquatox.2018.10.016.
doiMarić, P., Ahel, M., Senta, I., Terzić, S., Mikac, I., Žuljević, A. & Smital, T. (2017) Effect-directed analysis reveals inhibition of zebrafish uptake transporter Oatp1d1 by caulerpenyne, a major secondary metabolite from the invasive marine alga Caulerpa taxifolia. Chemosphere, 174, 643-654 doi:10.1016/j.chemosphere.2017.02.007.
doiMihaljević, I., Popović, M., Žaja, R., Maraković, N., Šinko, G. & Smital, T. (2017) Interaction between zebrafish Oct1 and endo- and xenobiotics. Aquatic toxicology, 187, 18-28 doi:10.1016/j.aquatox.2017.03.012.
doiDragojević, J., Mihaljević, I., Popović, M., Žaja, R. & Smital, T. (2017) In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicology in vitro, 46, 246-256 doi:10.1016/j.tiv.2017.09.026.
doiŽaja, R., Popović, M., Lončar, J. & Smital, T. (2016) Functional characterization of rainbow trout (Oncorhynchus mykiss) Abcg2a (Bcrp) transporter. Comparative biochemistry and physiology. C. Toxicology & pharmacology, 190, 15-23 doi:10.1016/j.cbpc.2016.07.005.
doiMihaljević, I., Popović, M., Žaja, R. & Smital, T. (2016) Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). Bmc genomics, 17, 626-1 doi:10.1186/s12864-016-2981-y.
doiLončar, J., Popović, M., Krznar, P., Žaja, R. & Smital, T. (2016) The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Scientific Reports, 6, 28937, 15 doi:10.1038/srep28937.
doiGlišić, B., Mihaljević, I., Popović, M., Žaja, R., Lončar, J., Fent, K., Kovačević, R. & Smital, T. (2015) Characterization of Glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology, 158, 50-62 doi:10.1016/j.aquatox.2014.10.013.
doiFerreira, M., Santosa, P., Rey-Salgueiroa, L., Žaja, R., Reis-Henriques, M. & Smital, T. (2014) The first demonstration of CYP1A and the ABC protein(s) gene expression and activity in European Seabass (Dicentrarchus labrax) primary hepatocytes. Chemosphere, 100, 152-159 doi:10.1016/j.chemosphere.2013.11.051.
doiPopović, M., Žaja, R., Fent, K. & Smital, T. (2014) Interaction of environmental contaminants with zebrafish uptake transporter Oatp1d1 (Slco1d1). Toxicology and applied pharmacology, 280, 149-158 doi:10.1016/j.taap.2014.07.015.
doiTraven, L., Mićović, V., Vukić Lušić, D. & Smital, T. (2013) The responses of the hepatosomatic index (HSI), 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione-S-transferase (GST) activity in sea bass (Dicentrarchus labrax, Linnaeus 1758) caged at a polluted site: implications for their use in environmental risk assessment. Environmental monitoring and assessment, 185 (11), 9009-9018 doi:10.1007/s10661-013-3230-3.
doiPopović, M., Žaja, R., Fent, K. & Smital, T. (2013) Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel Organic anion transporting polypeptide. The Journal of biological chemistry, 288 (47), 33894-33911 doi:10.1074/jbc.M113.518506.
doiBošnjak, I., Zaja, R., Sauerborn Klobučar, R., Šver, L., Franekić, J. & Smital, T. (2013) Identification of ABC Transporter Genes in Gonad Tissue of two Mediterranean Sea Urchin Species: Black, Arbacia lixula L., and Rocky, Paracentrotus lividus L.. Bulletin of environmental contamination and toxicology, 91 (4), 415-419 doi:10.1007/s00128-013-1021-8.
doiZaja, R., Terzić, S., Senta, I., Lončar, J., Popović, M., Ahel, M. & Smital, T. (2013) Identification of P-Glycoprotein Inhibitors in Contaminated Freshwater Sediments. Environmental science & technology, 47 (9), 4813-4821 doi:10.1021/es400334t.
doiSmital, T., Terzić, S., Lončar, J., Senta, I., Žaja, R., Popović, M., Mikac, I., Tollefsen, K., Thomas, K. & Ahel, M. (2013) Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays. Environmental science and pollution research international, 20 (3), 1384-1395 doi:10.1007/s11356-012-1059-x.
doiDella Torre, C., Žaja, R., Lončar, J., Smital, T., Focardi, S. & Corsi, I. (2012) Interaction of ABC transport proteins with toxic metals at the level of gene and transport activity in the PLHC-1 fish cell line. Chemico-biological interactions, 198 (1/3), 9-17 doi:10.1016/j.cbi.2012.04.008.
doiReifferscheid, G., Maes, H., Allner, B., Badurova, J., Belkin, S., Blum, K., Brauer, F., Bressling, J., Domeneghetti, S., Elad, T., Flückiger-Isler, S., Grummt, H., Guertler, R., Hecht, A., Heringa, M., Hollert, H., Huber, S., Kramer, M., Magdeburg, A., Ratte, T., Sauerborn-Klobucar, R., Sokolowski, A., Soldan, P., Smital, T., Stalter, D., Venier, P., Ziemann, C., Zipperle, J. & Buchinger, S. (2012) International round-robin study on the Ames fluctuation test. Environmental and molecular mutagenesis, 53 (3), 185-197 doi:10.1002/em.21677.
doiAhel, M., Mikac, N. & Smital, T. (2011) Water resources and wastewater management in the Sava River Basin. Danube News, 13 (24), 13-15.
Fischer, S., Lončar, J., Žaja, R., Schnell, S., Schirmer, K., Smital, T. & Luckenbach, T. (2011) Constitutive mRNAexpression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss). Aquatic toxicology, 101 (2), 438-446 doi:10.1016/j.aquatox.2010.11.010.
doiŽaja, R., Lončar, J., Popović, M. & Smital, T. (2011) First characterisation of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line. Aquatic toxicology, 103 (1/2), 53-62 doi:10.1016/j.aquatox.2011.02.005.
doiSmital, T., Terzić, S., Žaja, R., Senta, I., Pivčević, B., Popović, M., Mikac, I., Tollefsen, K., Thomas, K. & Ahel, M. (2011) Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays. Ecotoxicology and environmental safety, 74 (4), 844-851 doi:10.1016/j.ecoenv.2010.11.010.
doiBošnjak, I., Šegvić, T., Smital, T., Franekić Čolić, J. & Mladineo, I. (2011) Sea Urchin Embryotoxicity Test for Determination of Environmental Contaminants–Potential Role of the MRP Proteins. Water, air and soil pollution, 217 (1-4), 627-636 doi:10.1007/s11270-010-0615-6.
doiAhel, M., Antičić, T., Balog, T., Bilić, N., Guberina, B., Katušić Hećimović, S., Jerić, I., Klanjšček, T., Legović, T., Musić, S., Sabljić, A., Smital, T., Smith, D., Šmuc, T., Štefančić, H., Weber, I., Žinić, M., Ramljak, D. & Krajcar, S. (2010) The Ruder Boskovic Institute – Today and Tomorrow. Periodicum biologorum, 112 (4), 369-374.
hrcak.srce.hrSauerborn Klobučar, R., Žaja, R., Franjević, D., Brozović, A. & Smital, T. (2010) Presence of Ecotoxicologically Relevant Pgp- and MRP- Transcripts and Proteins in Cyprinid Fish. Arhiv za higijenu rada i toksikologiju, 61 (2), 175-181. (https://www.bib.irb.hr/446731).
hrcak.srce.hrPopović, M., Žaja, R. & Smital, T. (2010) Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): phylogenetic analysis and tissue distribution. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 155 (3), 327-335 doi:10.1016/j.cbpa.2009.11.011.
doiLončar, J., Popović, M., Žaja, R. & Smital, T. (2010) Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. C. Toxicology & pharmacology, 151 (2), 209-215 doi:10.1016/j.cbpc.2009.10.009.
doiPopović, M., Žaja, R., Lončar, J. & Smital, T. (2010) A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1. Marine environmental research, 69 (S1), S11-S13 doi:10.1016/j.marenvres.2009.10.016.
doiBošnjak, I., Heim, W., Smital, T., Epel, D., Coale, K., Franekić-Čolić, J. & Hamdoun, A. (2009) Multidrug resistance associated protein transport activity mediates differences in accumulation and toxicity of inorganic and organic mercury in sea urchin embryos. Environmental science & technology, 43, 8374-8380.
Traven, L., Žaja, R., Lončar, J., Smital, T. & Mićović, V. (2008) CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicology in vitro, 22 (6), 1648-1656 doi:10.1016/j.tiv.2008.06.012.
doiCaminada, D., Žaja, R., Smital, T. & Fent, K. (2008) Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1. Aquatic toxicology, 90 (3), 214-222 doi:10.1016/j.aquatox.2008.08.013.
doiEpel, D., Stevenson, C., MacManus-Spencer, L., Luckenbach, T., Hamdoun, A. & Smital, T. (2008) Efflux transporters: newly appreciated roles in protection against pollutants. Environmental Science and Technology, 42 (11), 3914-3920.
Žaja, R., Munić, V., Sauerborn Klobučar, R., Ambriović-Ristov, A. & Smital, T. (2008) Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology, 90 (4), 322-332.
Žaja, R., Caminada, D., Lončar, J., Fent, K. & Smital, T. (2008) Development and characterization of P-glycoprotein 1 (Pgp1 ; ABCB1) mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line. Toxicology and Applied Pharmacology, 227 (2), 207-218 doi:10.1016/j.taap.2007.11.001.
doiŽaja, R., Munić, V. & Smital, T. (2008) Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes. Marine Environmental Research, 66 (1), 77-79.
Källqvist, T., Milačič, R., Smital, T., Thomas, K., Vranes, S. & Tollefsen, K. (2007) Chronic toxicity of the Sava River (SE Europe) sediments and river water to the algae Pseudokirchneriella subcapitata. Water Research, 42 (8-9), 2146-2156 doi:10.1016/j.watres.2007.11.026.
doiKrča, S., Žaja, R., Čalić, V., Terzić, S., Grubešić, M., Ahel, M. & Smital, T. (2007) Hepatic biomarker responses to organic contaminants in feral chub (Leuciscus Cephalus) -laboratory characterization and field study in the Sava river, Croatia. Environmental Toxicology and Chemistry, 26 (12), 2620-2633.
Žaja, R., Sauerborn Klobučar, R. & Smital, T. (2007) Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquatic toxicology, 81, 365-376.
Žaja, R., Klobučar, G., Sauerborn Klobučar, R., Hackenberger, B. & Smital, T. (2006) Haemolymph as compartment for efficient and non-destructive determination of Pgp mediated MXR activity in bivalves. Comparative biochemistry and physiology. C. Toxicology & pharmacology, 143 (1), 103-112.
Smital, T., Luckenbach, T., Sauerborn, R., Hamdoun, M., Vega, L. & Epel, D. (2004) Emerging contaminants - pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutation Research, 552, 101-117.
Pivčević, B., Sauerborn Klobučar, R., Krča, S., Žaja, R., Jelaska, D., Smital, T. & Britvić Smiljana (2004) Methods of molecular biology in ecotoxicological research. Periodicum Biologorum, 106 (2), 121-125.
Sauerborn, R., Stupin Polancec, D., Zaja, R. & Smital, T. (2004) Identification of the multidrug resistance-associated protein (mrp) related gene in red mullet (Mullus barbatus). Marine environmental research, 58 (2-5), 199-204 doi:10.1016/j.marenvres.2004.03.120.
doiSmital, T., Sauerborn, R. & Hackenberger, B. (2003) Inducibility of the multixenobiotic resistance mechanism (MXR) transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha. Aquatic Toxicology, 65, 443-465.
Smital, T. & Sauerborn, R. (2002) Measurement of the activity of multixenobiotic resistance mechanism in the common carp Cyprinus carpio. Marine environmental research, 54 (3/5), 449-453 doi:10.1016/S0141-1136(02)00155-1.
doiRamljak, S., Hackenberger, B., Smital, T. & Britvić, S. (2000) Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems. Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 35 (6), 751-770.
Kurelec, B., Smital, T., Pivčević, B., Eufemia, N. & Epel, D. (2000) Multixenobiotic resistance, P-glycoprotein, and chemosensitizers. Ecotoxicology, 9 (5), 307-327.
Smital, T., Sauerborn, R., Pivčević, B., Krča, S. & Kurelec, B. (2000) Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates. Comparative Biochemistry and Physiology C, 126, 175-186.
Kurelec, B., Britvić, S., Pivčević, B. & Smital, T. (1998) Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment. Marine environmental research, 46 (1-5), 415-419 doi:10.1016/S0141-1136(97)00065-2.
doiSmital, T. & Kurelec, B. (1998) The activity of multixenobiotic resistance mechanism determined by rhodamine B-efflux method as a biomarker of exposure. Marine environmental research, 46 (1-5), 443-447 doi:10.1016/S0141-1136(97)00087-1.
doiOsmak, M., Brozović, A., Ambriović-Ristov, A., Hadžija, M., Pivčević, B. & Smital, T. (1998) Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. Neoplasma, 45 (4), 223-230.
Kurelec, B., Smital, T., Britvić, S., Pivčević, B., Krča, S., Jelaska, D., Balen, S., Sauerborn, R. & Mustajbegović, S. (1997) Multixenobiotic resistance mechanism in aquatic organisms. Periodicum biologorum, 99 (3), 319-328.
Smital, T. & Kurelec, B. (1997) The concentrations of inhibitors of multixenobiotic resistance mechanism in natural waters: The direct in vivo demonstration of their effect. Environmental toxicology and chemistry, 16 (10), 2164-2170.
Smital, T., Pivčević, B. & Kurelec, B. (1996) Reversal of multidrug resistance by extract from a marine algae Caulerpa taxifolia. Periodicum biologorum, 98 (2), 197-203.
Dražić, M., Bubalo, D., Smital, T., Krča, Sanja, Britvić, Smilja & Kezić, N. (2005) Ekspresija mehanizma multiksenobiotičke otpornosti izlaganjem pčela aktivnim tvarima lijekova. U: Kovačević, V. & Jovanovac, S. (ur.)Proceedings, XL Croatian Symposium on Agriculture.
Hackenberger, B., Hylland, K., Raspor, B., Smital, T., Klobučar, G. & Stepić, S. (2003) Primjenjivost molekularnih biomarkera u kontroli kvalitete voda Hrvatske. U: Gereš, D. (ur.)3. hrvatska konferencija o vodama Hrvatske vode u 21. stoljeću : zbornik radova = 3rd Croatian Conference on Waters Croatian waters in the 21st century : proceedings.
Sauerborn, R., Stupin Polancec, D., Zaja, R. & Smital, T. (2003) Identification of the multidrug resistance-associated protein (MRP) related genes in several marine and freshwater fish species. U: 12th International Symposium on Pollutant Responses in Marine Organisms (PRIMO12) : conference proceedings.
Kurelec, B., Smital, T. & Pivčević, B. (1996) Iscrpak iz tropske alge unijete u Sredozemlje, Caulerpa taxifolia, preobraća istovremenu otpornost na lijekove (MDR) u kulturi stanica.
Smital, T. (1999) 'Aktivnost mehanizma multiksenobiotičke otpornosti u vodenih organizama kao pokazatelj kvalitete okoliša', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Smital, T. (1998) 'In vivo određivanje koncentracije inhibitora mehanizma multiksenobiotičke otpornosti (MXR) u riječnim vodama', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.
Član Hrvatskog biološkog društva, Hrvatskog toksikološkog društva i Society of Ecotoxicology and Environmental Safety (SECOTOX).
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