dr. sc. Vesna Musani
10002 Zagreb
Obrazovanje
- 1989.-1993. - V Gimnazija, Zagreb
- 1993.-1999. - dipl.inž. biologije, smjer molekularna biologija Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
- 2008. - doktor znanosti, područje prirodnih znanosti, znanstveno polje biologija Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
Nagrade i priznanja
- kongresna stipendija za prisustvovanje na 10th International Congress of Human Genetics (ICHG) 15-19.05.2001, Beč, Austrija
- putna stipendija Ministarstva znanosti, obrazovanja i športa za prisustvovanje na 11th World Congress on Advances in Oncology, and 9th International Symposium on Molecular Medicine, 12-14.10.2006, Hersonissos, Kreta, Grčka
- putna stipendija Ministarstva znanosti, obrazovanja i športa za prisustvovanje na 12th World Congress on Advances in Oncology, 10th International Symposium on Molecular Medicine, 11-13.10.2007, Hersonissos, Kreta, Grčka
- stipendija Hrvatskog društva za humanu genetiku za prisustvovanje na European Human Genetics Conference 2009 (ESHG), 23-26.05.2009, Beč, Austrija
- kongresna stipendija za prisustvovanje na European Human Genetics Conference 2010 (ESHG), 12-15.06.2010, Gőteburg, Švedska
- stipendija European Society of Human Genetics za prisustvovanje na 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting 2011, 11-15.10.2011, Montreal, Kanada
Nastava
- suradnica u poslijediplomskoj nastavi (voditelj dr.sc. Sonja Levanat) – kolegiji "Molekularno-genetički i biokemijski procesi u stanici", doktorski studij, Medicinski fakultet, Sveučilište u Zagrebu i "Biološke metode u genetičkoj toksikologiji", poslijediplomski studij, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
- suradnica u diplomskoj nastavi (voditelj dr.sc. Sanja Kapitanović) - kolegij "Molekularna dijagnostika", diplomski studij Molekularna biologija, modul Biologija čovjeka
- suradnica u nastavi Specijalističkog studija sanitarnog inženjerstva, kolegija "Metode rekombinantne DNA"
Istaknute publikacije
- Musani V, Sabol M, Car D, Ozretić P, Orešković S, Leović D, Levanat S: LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Front Biosci (2011) [in print]
- Muzio LL, Pastorino L, Levanat S, Musani V, Situm M, Scarra GB: Clinical utility gene card for: Gorlin syndrome. Eur J Hum Genet 19(8). doi: 10.1038/ejhg.2011.9. (2011)
- Musani V, Cretnik M, Situm M, Basta-Juzbasic A, Levanat S. Gorlin Syndrome patient with large deletion in 9q22.32-q22.33 detected by Quantitative Multiplex Fluorescent PCR. Dermatology 219(2):111-118 (2009)
- Levačić Cvok M, Čretnik M, Musani V, Ozretić P, Levanat S: New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. Clin Chem Lab Med 46(10):1376-1383 (2008)
- Musani V, Gorry P, Basta-Juzbašić A, Stipić T, Miklić P, Levanat S: Mutation in exon 7 of PTCH deregulates SHH/PTCH/SMO signaling: possible linkage to WNT. Int J Mol Med 17(5):755-759 (2006)
- Levanat S, Kappler R, Hemmerlein B, Döring P, Musani V, Komar A, Orešković S, Pavelić B, Hahn H: Analysis of the PTCH1 signaling pathway in ovarian dermoids. Int J Mol Med 14(5):793-799 (2004)
Publikacije
Knjige i poglavlja u knjigama
Poglavlja u knjigama
Musani, V., Ozretić, P. & Levanat, S. (2019) Molecular biology of breast cancer. U: Beketić-Orešković, L. & Šantek, F. (ur.) Breast cancer. Zagreb, Medicinska naklada, str. 34-45.
Musani, V., Ozretić, P. & Levanat, S. (2018) Molekularna biologija karcinoma dojke. U: Beketić-Orešković, L. & Šantek, F. (ur.) Karcinom dojke. Zagreb, Medicinska naklada, str. 34-45.
Musani, V., Ozretić, P. & Levanat, S. (2016) Molekularna biologija raka dojke. U: Beketić-Orešković, L. & Šantek, F. (ur.) Multidisciplinarno liječenje bolesnica s rakom dojke. Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, str. 23-31.
Radovi u časopisima
Znanstveni i pregledni radovi
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Piteša, N., Kurtović, M., Bartoniček, N., Gkotsi, D., Čonkaš, J., Petrić, T., Musani, V., Ozretić, P., Riobo-Del Galdo, N. & Sabol, M. (2023) Signaling switching from Hedgehog-GLI to MAPK signaling potentially serves as a compensatory mechanism in melanoma cell lines resistant to GANT-61. Biomedicines, 11, 1353, 19 doi:10.3390/biomedicines11051353.
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Kurtović, M., Piteša, N., Bartoniček, N., Ozretić, P., Musani, V., Čonkaš, J., Petrić, T., King, C. & Sabol, M. (2022) RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. Cancers, 14 (18), 4540, 20 doi:10.3390/cancers14184540.
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Trnski, D., Sabol, M., Tomić, S., Štefanac, I., Mrčela, M., Musani, V., Rinčić, N., Kurtović, M., Petrić, T., Levanat, S. & Ozretić, P. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific reports, 11 (1), 14880, 11 doi:10.1038/s41598-021-93971-6.
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Zubčić, V., Rinčić, N., Kurtović, M., Trnski, D., Musani, V., Ozretić, P., Levanat, S., Leović, D. & Sabol, M. (2020) GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. International journal of molecular sciences, 21, 6410, 13 doi:10.3390/ijms21176410.
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Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
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Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.
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Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.
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Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.
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Čačev, T., Zapletal, E., Musani, V., Rako, I., Lončar, B., Aralica, G. & Kapitanović, S. (2018) Analysis of MSH2 Loss of Heterozygosity, Expression, and IVS10+12G>A Polymorphism in Sporadic Colon Cancery. Anticancer research, 38 (5), 2841-2848 doi:10.21873/anticanres.12529.
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Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.
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Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.
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Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.
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Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.
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Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.
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Kafka, A., Musani, V. & Pećina-Šlaus, N. (2014) Optimal amplification conditions for D16S3399 polymorphic STS Axin-1 gene marker. Periodicum biologorum, 116 (2), 197-199.
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Lo Muzio, L., Pastorino, L., Levanat, S., Musani, V., Šitum, M., Ponti, G. & Bianchi, Scarra, G. (2013) Clinical utility gene card for:Gorlin syndrome - update 2013. European journal of human genetics, 21, e1-e3 doi:10.1038/ejhg.2012.299.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.
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Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
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Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.
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Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), 4 (3), 1049-1057 doi:10.2741/E440.
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Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.
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Lo Muzio, L., Pastorino, L., Levanat, S., Musani, V., Šitum, M. & Bianchi Scarra, G. (2011) Clinical utility gene card for : Gorlin syndrome. European journal of human genetics, 19 (8), npg-npg doi:10.1038/ejhg.2011.9.
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Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.
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Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.
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Pećina-Šlaus, N., Nikuševa Martić, T., Deak, A., Zeljko, M., Hrašćan, R., Tomas, D. & Musani, V. (2010) Genetic and protein changes of E-cadherin in meningiomas. Journal of cancer research and clinical oncology, 136 (5), 695-702 doi:10.1007/s00432-009-0708-z.
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Pećina-Šlaus, N., Majić, Ž., Musani, V., Zeljko, M. & Čupić, H. (2010) Report on mutation in exon 15 of the APC gene in a case of brain metastasis. Journal of neuro-oncology, 97 (1), 143-148 doi:10.1007/s11060-009-0001-7.
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Sansović, I., Knežević, J., Musani, V., Seeman, P., Barišić, I. & Pavelić, J. (2009) GJB2 mutations in patients with non-syndromic hearing loss from Croatia. Genetic Testing and Molecular Biomarkers, 13 (5), 693-699 doi:10.1089/gtmb.2009.0073.
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Musani, V., Čretnik, M., Šitum, M., Basta-Juzbašić, A. & Levanat, S. (2009) Gorlin Syndrome Patient with Large Deletion in 9q22.32-q22.33 Detected by Quantitative Multiplex Fluorescent PCR. Dermatology (Basel), 219 (2), 111-118 doi:10.1159/000219247.
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Čretnik, M., Poje, G., Musani, V., Krušlin, B., Ozretić, P., Tomas, D., Šitum, M. & Levanat, S. (2009) Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. International journal of oncology, 34 (4), 1045-1050 doi:10.3892/ijo_00000230.
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Willems, P., Magri, V., Čretnik, M., Fasano, M., Jakubowska, A., Levanat, S., Lubinski, J., Marras, E., Musani, V., Thierens, H., Vandersickel, V., Perletti, G. & Vral, A. (2009) Characterization of the c.190T>C missense mutation in BRCA1 codon 64 (Cys64Arg). International journal of oncology, 34 (4), 1005-1015 doi:10.3892/ijo_00000226.
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Levačić Cvok, M., Čretnik, M., Musani, V., Ozretić, P. & Levanat, S. (2008) New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. Clinical Chemistry and Laboratory Medicine, 46 (10), 1376-1383 doi:10.1515/CCLM.2008.307.
doifulir.irb.hr Levanat, S., Čretnik, M. & Musani, V. (2008) Hh-Gli Signaling Pathway Functions and its Therapeutic Potential in Cancer. Croatica Chemica Acta, 81 (1), 1-5.
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Bura, M., Musani, V., Čretnik, M., Botica, I. & Levanat, S. (2008) Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. Oncology Reports, 20 (2), 347-352 doi:10.3892/or_00000013.
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Čretnik, M., Musani, V., Orešković, S., Leović, D. & Levanat, S. (2007) The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. International Journal of Molecular Medicine, 19 (6), 875-883 doi:10.3892/ijmm.19.6.875.
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Musani, V., Gorry, P., Basta-Juzbašić, A., Stipić, T., Miklić, P. & Levanat, S. (2006) Mutation in exon 7 of PTCH deregulates SHH/PTCH/SMO signaling : Possible linkage to WNT. International journal of molecular medicine, 17 (5), 755-759 doi:10.3892/ijmm.17.5.755.
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Levanat, S., Kappler, R., Hemmerlein, B., Doring, P., Musani, V., Komar, A., Orešković, S., Pavelić, B. & Hahn, H. (2004) Analysis of alterations of the PTCH1 signaling pathway in ovarian dermoids. International journal of molecular medicine, 14 (5), 793-799 doi:10.3892/ijmm.14.5.793.
doi Levanat, S., Musani, V. & Komar, A. (2004) The Hedgehog/Patched signaling pathway (SHH/PTCH/SMO) in cancer and development. Periodicum biologorum, 106 (3), 23-27.
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Levanat, S., Musani, V., Komar, A. & Orešković, S. (2004) Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma. Annals of the New York Academy of Sciences, 1030 (1), 134-143 doi:10.1196/annals.1329.017.
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Levanat, S., Šitum, M., Crnić, I., Marasović, D., Puizina-Ivić, N., Pokupčić, N., Musani, V., Komar, A., Kubat, M., Furač, I., Karija-Vlahović, M. & Križanac, Š. (2003) Alterations in CDKN2A Locus as Potential Indicator of Melanoma Predisposition in Relatives of Non-Familial Melanoma Cases. Croatian medical journal, 44 (4), 418-424.
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Balog, T., Marotti, T., Musani, V., Sobočanec, S. & Šverko, V. (2001) The effect of methionine enkephalin on nitric oxide release in mice is age and gender related. Pharmacological research, 44 (4), 287-292 doi:10.1006/phrs.2001.0866.
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Ocjenski radovi
Doktorske disertacije
Musani, V. (2008) 'Mehanizmi regulacije signalnog puta Hedgehog/Patched/Gli u tumorima i nasljednim oboljenjima', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Članstva u profesionalnim udrugama / društvima
- Hrvatsko društvo za humanu genetiku
- European Society of Human Genetics
- Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB)
- Hrvatsko društvo za istraživanje raka (HDIR)
- European Association for Anticancer Research (EACR)