dr. sc. Maja Jazvinšćak Jembrek
Institut Ruđer Bošković
Bijenička 54
HR-10000 Zagreb
Obrazovanje
2007: doktorica znanosti iz područja prirodnih znanosti, znanstveno polje biologija
Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu
2000: magistra znanosti iz područja prirodnih znanosti, znanstveno polje biologija
Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu
1996: dipl.inž. biologije
Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu
Nastava
suradnica u nastavi kolegija "Neuroimunologija", diplomska nastava, smjer: Eksperimentalna biologija, PMF, Zagreb
Istaknute publikacije
- Jazvinšćak Jembrek M, Švob Štrac D, Vlainić Lazić J and Peričić D: transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA-A receptors. Neurosci. Res. 61: 234-241 (2008)
- Peričić D, Jazvinšćak Jembrek M, Švob Štrac D, Lazić J, Rajčan Špoljarić I: Enhancem ent of benzodiazepine binding sites following chronic treatment with flumazenil: Eur. J. Pharmacol. 507 (1-3):7-13 (2005)
- Peričić D, Lazić J, Jazvinšćak Jembrek M, Švob Štrac D, Rajčan I: Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites: Life Sci. 76(3): 303-317 (2004)
- Peričić D, Jazvinšćak M, Mirković K: [3H]Flunitrazepam binding to recombinant a1b2g2S GABAA receptors stably expressed in HEK 293 cells: Biomed. Pharmacother. 55 (4): 221-228 (2001)
- Peričić D, Švob D, Jazvinšćak M, Mirković K: Anticonvulsive effect of swim stress in mice. Pharmacol. Biochem. Beh. 66(4): 879-886 (2000).
- Peričić D, Mirković K, Jazvinšćak M, Besnard F: [3H]t-butylbicycloorthobenzoate binding to recombinant a1b2g2S GABAA receptor. Eur. J. Pharmacol. 360(1):99-104 (1998)
Publikacije
Knjige i poglavlja u knjigama
Poglavlja u knjigama
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Kosalec, I., Jazvinšćak Jembrek, M. & Vlainić, J. (2022) The spectrum of berberine antibacterial and antifungal activities. U: Rai, M. & Kosalec, I. (ur.) Promising antimicrobials from natural products. Cham, Springer, str. 119-132 doi:10.1007/978-3-030-83504-0_7.
doi Zubčić, K., Šimić, G. & Jazvinšćak Jembrek, M. (2020) p53-mediated neuroprotective effects of natural compounds in oxidative stress conditions. U: Stevens, M. (ur.) p53 – structure, function and role in disease. New York, Nova Science Publishers, str. 127-181.
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Jazvinšćak Jembrek, M., Newberg, K. & Šimić, G. (2019) The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology. U: Singh, S. & Joshi, N. (ur.) Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Singapore, Springer, str. 39-48 doi:10.1007/978-981-13-0944-1_4.
doi Vlainić, J. & Jazvinšćak Jembrek, M. (2017) GABA(γ-Aminobutyric Acid). U: Sangdun Choi (ur.) Encyclopedia of Signaling Molecules. New York, Springer, str. 1-6.
Oršolić, N., Goluža, E. & Jazvinšćak Jembrek, M. (2015) The Effectiveness of Quercetin on Biomarkers for Osteoporosis. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York, Nova Science Publishers, Inc., str. 133-160.
Jazvinšćak Jembrek, M., Vlainić, J. & Oršolić, N. (2015) Dual Effects of Quercetin in Physiological Conditions and During Oxidative Injury in P19 Neurons. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York, Nova Science Publishers, Inc., str. 111-132.
Oršolić, N. & Jazvinšćak Jembrek, M. (2015) Multimodal Approach to Tumor Therapy with Quercetin, Chemotherapy, Radiotherapy and Hyperthermia. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York, Nova Science Publishers, Inc., str. 43-84.
Jazvinšćak Jembrek, M., Babić, M., Pivac, N. & Šimić, G. (2015) Interplay between Aβ, Ceramides and Hyperphosphorylated Tau in Alzheimer’s Disease. U: Watkins, C. (ur.) Sphingomyelin and Ceramides: Occurrence, Biosynthesis and Role in Disease. New York, Nova Science Publishers, Inc., str. 53-84.
Jazvinšćak Jembrek, M., Vlainić, J. & Radovanović, V. (2014) The role of GABA in development and behaviour: emphasize on the effects of GABA receptor agonists and antagonists. U: Vlainić, J. & Jazvinšćak Jembrek, M. (ur.) Gamma-aminobutyric Acid (GABA): biosynthesis, medicinal uses and health effects. New York, Nova Science Publishers, str. 49-70.
Vlainić, J., Švob Štrac, D. & Jazvinšćak Jembrek, M. (2014) The effects of persistent activation of GABA-A receptors by neurotransmitter GABA. U: Vlainić, J. & Jazvinšćak Jembrek, M. (ur.) Gamma-aminobutyric Acid (GABA): biosynthesis, medicinal uses and health effects. New York, Nova Science Publishers, str. 29-48.
Švob Štrac, D., Vlainić, J., Jazvinšćak Jembrek, M., Muck-Šeler, D. & Pivac, N. (2012) The Effects of Benzodiazepines during Prolonged Administration and Under the Conditions of Stress. U: Soto, A. & Reyes, C. (ur.) Benzodiazepine: Abuse and Therapeutic Uses, Pharmacology and Health Effects. New York, USA, Nova Science Publishers, Inc., str. 1-54.
Pivac, N., Nedić, G., Nikolac, M., Mustapić, M., Švob Štrac, D., Jazvinšćak Jembrek, M. & Muck-Šeler, D. (2011) Molecular mechanisms of traumatic brain injury. U: Wiederhold, B. (ur.) Traumatic brain injury. Wounds of war III.. Amsterdam, IOS Press, str. 81-111.
Radovi u časopisima
Znanstveni i pregledni radovi
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Vuić, B., Miloš, T., Tudor, L., Konjevod, M., Nikolac Perković, M., Jazvinšćak Jembrek, M., Nedić Erjavec, G. & Švob Štrac, D. (2022) Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines, 10 (12), 3000, 31 doi:10.3390/biomedicines10123000.
doiwww.ncbi.nlm.nih.govwww.mdpi.comfulir.irb.hr -
Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. International Journal of Molecular Sciences, 23 (18), 10479, 68 doi:10.3390/ijms231810479.
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Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11 (10), 2049, 36 doi:10.3390/antiox11102049.
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Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.
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Oršolić, N., Nemrava, J., Jeleč, Ž., Kukolj, M., Odeh, D., Jakopović, B., Jazvinšćak Jembrek, M., Bagatin, T., Fureš, R. & Bagatin, D. (2022) Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats. International journal of molecular sciences, 23, 2872, 24 doi:10.3390/ijms23052872.
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Jazvinšćak Jembrek, M., Oršolić, N., Mandić, L., Sadžak, A. & Šegota, S. (2021) Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration. Antioxidants, 10 (10), 1628, 46 doi:10.3390/antiox10101628.
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Oršolić, N., Sirovina, D., Odeh, D., Gajski, G., Balta, V., Šver, L. & Jazvinščak Jembrek, M. (2021) Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules, 26 (11), 3262, 25 doi:10.3390/molecules26113262.
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Sadžak, A., Vlašić, I., Kiralj, Z., Batarelo, M., Oršolić, N., Jazvinšćak Jembrek, M., Kušen, I. & Šegota, S. (2021) Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules, 26 (4), 845, 28 doi:10.3390/molecules26040845.
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Zubčić, K., Hof, P., Šimić, G. & Jazvinšćak Jembrek, M. (2020) The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 13, 572308, 19 doi:10.3389/fnmol.2020.572308.
doiwww.frontiersin.orgdoi.orgfulir.irb.hr -
Oršolić, N., Odeh, D., Jazvinšćak Jembrek, M., Knežević, J. & Kučan, D. (2020) Interactions between Cisplatin and Quercetin atPhysiological and Hyperthermic Conditions onCancer Cells In Vitro and In Vivo. Molecules, 25 (14), 3271, 25 doi:10.3390/molecules25143271.
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Zubčić, K., Radovanović, V., Vlainić, J., Hof, P., Oršolić, N., Šimić, G. & Jazvinšćak Jembrek, M. (2020) PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury. Oxidative medicine and cellular longevity, 2020, 9834742, 14 doi:10.1155/2020/9834742.
doiwww.hindawi.comdoi.orgfulir.irb.hr -
Radovanović, V., Vlainić, J., Hanžić, N., Ukić, P., Oršolić, N., Baranović, G. & Jazvinšćak Jembrek, M. (2019) Neurotoxic effect of ethanolic extract of propolis in the presence of copper ions is mediated through enhanced production of ROS and stimulation of caspase-3/7 activity. Toxins, 11 (5), 273, 18 doi:10.3390/toxins11050273.
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Jazvinšćak Jembrek, M., Vlainić, J., Čadež, V. & Šegota, S. (2018) Atomic force microscopy reveals new biophysical markers for monitoring subcellular changes in oxidative injury: Neuroprotective effects of quercetin at the nanoscale. PLoS One, 13 (10), 0200119-0200141 doi:10.1371/journal.pone.0200119.
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Jazvinšćak Jembrek, M., Radovanović, V., Vlainić, J., Vuković, L. & Hanžić, N. (2018) Neuroprotective effect of zolpidem against glutamate-induced toxicity is mediated via the PI3K/Akt pathway and inhibited by PK11195. Toxicology, 406-407, 58-69.
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Jazvinšćak Jembrek, M., Slade, N., Hof, P. & Šimić, G. (2018) The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in neurobiology, 168, 104-127 doi:10.1016/j.pneurobio.2018.05.001.
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Jazvinšćak Jembrek, M., Auteri, M., Serio, R. & Vlainić, J. (2017) GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders.. Current pharmaceutical design, 23 (27), 4003-4011 doi:10.2174/1381612823666170209155753.
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Oršolić, N., Jazvinšćak Jembrek, M. & Terzić, S. (2017) Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora. Food and agricultural immunology, 28 (5), 812-833 doi:10.1080/09540105.2017.1313819.
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Jazvinšćak Jembrek, M., Hof, P. & Šimić, G. (2015) Ceramides in Alzheimer’s Disease : Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation. Oxidative Medicine and Cellular Longevity,, 346783-1 doi:10.1155/2015/346783.
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Jazvinšćak Jembrek, M. & Vlainić, J. (2015) GABA receptors: pharmacological potential and pitfalls. Current Pharmaceutical Design, 21 (34), 4943-4959 doi:10.2174/1381612821666150914121624.
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Jazvinšćak Jembrek, M., Vlainić, J. & Šuran, J. (2015) Zolpidem withdrawal induced uncoupling of GABAA receptors in vitro associated with altered GABAA receptor subunit mRNA expression. Acta neurobiologiae experimentalis, 75 (2), 160-171. (https://www.bib.irb.hr/769819).
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Jazvinšćak Jembrek, M., Šimić, G., Hof, P. & Šegota, S. (2015) Atomic force microscopy as an advanced tool in neuroscience. Translational Neuroscience, 6 (1), 117-130 doi:10.1515/tnsci-2015-0011.
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Jazvinšćak Jembrek, M., Vlainić, J., Radovanović, V., Erhardt, J. & Oršolić, N. (2014) Effects of copper overload in P19 neurons : impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. BioMetals, 27 (6), 1303-1322 doi:10.1007/s10534-014-9792-x.
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Jazvinšćak Jembrek, M., Babić, M., Pivac, N., Hof, P. & Šimić, G. (2013) Hyperphosphorylation of tau by GSK-3β in Alzheimer’s disease: The interaction of Aβ and sphingolipid mediators as a therapeutic target. Translational Neuroscience, 4 (4), 466-476 doi:10.2478/s13380-013-0144-z.
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Oršolić, N., Sirovina, D., Gajski, G., Garaj-Vrhovac, V., Jazvinšćak Jembrek, M. & Kosalec, I. (2013) Assessment of DNA damage and lipid peroxidation in diabetic mice : effects of propolis and epigallocatechin gallate (EGCG). Mutation research. Genetic toxicology and environmental mutagenesis, 757 (1), 36-44 doi:10.1016/j.mrgentox.2013.04.022.
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Jazvinšćak Jembrek, M., Čipak Gašparović, A., Vuković, L., Vlainić, J., Žarković, N. & Oršolić, N. (2012) Quercetin supplementation : Insight into the potentially harmful outcomes of neurodegenerative prevention. Naunyn-Schmiedeberg's archives of pharmacology, 385 (12), 1185-1197 doi:10.1007/s00210-012-0799-y.
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Jazvinšćak Jembrek, M., Vuković, L., Puhović, J., Erhardt, J. & Oršolić, N. (2012) Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons. Journal of molecular neuroscience, 47 (2), 286-299 doi:10.1007/s12031-012-9737-1.
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Vlainić, J., Švob Štrac, D., Jazvinšćak Jembrek, M., Vlainić, T. & Peričić, D. (2012) The effects of zolpidem treatment on GABAA receptors in cultured cerebellar granule cells: Changes in functional coupling. Life sciences, 90 (23-24), 889-894 doi:10.1016/j.lfs.2012.04.021.
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Švob Štrac, D., Jazvinšćak Jembrek, M., Erhardt, J., Mirković Kos, K. & Peričić, D. (2012) Modulation of recombinant GABA-A receptors by neurosteroid dehydroepiandrosterone sulphate. Pharmacology, 89 (3/4), 163-171 doi:10.1159/000336058.
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Vlainić, J., Jazvinšćak Jembrek, M., Vlainić, T., Švob Štrac, D. & Peričić, D. (2012) Differential effects of short- and long-term zolpidem treatment on recombinant alpha 1 beta 2 gamma 2s subtype of GABA(A) receptors in vitro. Acta pharmacologica Sinica, 33 (12), 1469-1476 doi:10.1038/aps.2012.89.
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Vlainić, J., Jazvinšćak Jembrek, M., Švob Štrac, D. & Peričić, D. (2010) The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA-A receptors expressed in HEK 293 cells. Naunyn-Schmiedeberg's archives of pharmacology, 382 (3), 201-212 doi:10.1007/s00210-010-0539-0.
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Švob Štrac, D., Vlainić Lazić, J., Jazvinšćak Jembrek, M. & Peričić Danka (2008) Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling. Brain research, 1246, 29-40 doi:10.1016/j.brainres.2008.09.093.
doi Jazvinšćak Jembrek, M., Švob Štrac, D., Vlainić Lazić, J. & Peričić, D. (2008) The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABAA receptors. Neuroscience Research, 61 (3), 234-241.
Peričić, D., Švob Štrac, D., Jazvinšćak Jembrek, M. & Vlainić Lazić, J. (2007) Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1 beta2 gamma2s subunits of GABA-A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (3), 177-187.
Peričić, D., Lazić, J., Jazvinšćak Jembrek, M. & Švob Štrac, D. (2005) Stimulation of 5-HT1A receptors increases the seizure threshold for picrotoxin in mice. European Journal of Pharmacology, 527 (1-3), 105-110.
Peričić, D., Jazvinšćak Jembrek, M., Švob Štrac, D., Vlainić (Lazić), J. & Rajčan Špoljarić, I. (2005) Enhancement of benzodiazepine binding sites following chronic treatment with flumazenil. European Journal of Pharmacology, 507 (1-3), 7-13.
Peričić, D., Lazić, J., Jazvinšćak Jembrek, M., Švob Štrac, D. & Rajčan, I. (2004) Chronic exposure of cells expressing recombinant GABA A receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites. Life Sciences, 76 (3), 303-317.
Peričić, D., Švob Štrac, D., Jazvinšćak Jembrek, M. & Rajčan, I. (2003) Prolonged exposure to gamma-aminobutyric acid up-regulates stably expressed recombinant alpha1 beta2 gamma2s GABA A receptors. European Journal of Pharmacology, 482, 117-125.
Peričić, D., Švob, D., Jazvinšćak Jembrek, M. & Mirković Kos, K. (2001) The involvement of alpha(2)-adrenoceptors in the anticonvulsive effect of swim stress in mice. Psychopharmacology, 158 (1), 87-93.
Peričić, D., Jazvinšćak, M. & Mirković, K. (2001) [3H]Flunitrazepam binding to recombinant alpha1 beta2 gamma 2s GABA-A receptors stably expressed in HEK 293 cells. Biomedicine and pharmacotherapy, 55 (4), 221-228.
Peričić, D., Jazvinšćak, M., Švob, D. & Mirković, K. (2001) Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants. Epilepsy research, 43 (2), 145-152.
Peričić, D., Jazvinšćak, M., Švob, D. & Mirković, K. (2000) Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice. Pharmacology Biochemistry and Behavior, 67 (3), 507-510.
Peričić, D., Švob, D., Jazvinšćak, M. & Mirković, K. (2000) Anticonvulsive effect of swim stress in mice. Pharmacology biochemistry and behavior, 66 (4), 879-886.
Peričić, D., Bujas, M., Mirković, K. & Jazvinšćak, M. (1999) The effects of adrenalectomy and gonadectomy on sex and stress-induced differences in the sensitivity of rats to bicuculline. Experimental brain research, 129 (3), 451-456.
Peričić, D., Mirković, K., Jazvinšćak, M. & Besnard, F. (1998) (3H)t-butylbicycloorthobenzoate binding to recombinant alpha1 beta2 gamma2s GABA-A receptor. European journal of pharmacology, 360 (1), 99-104.
Bujas, M., Peričić, D. & Jazvinšćak, M. (1997) Influence of gender and gonadectomy on bicuculline-induced convulsions and on GABA-A receptors. Brain research bulletin, 43 (4), 411-416.
Ocjenski radovi
Doktorske disertacije
Jazvinšćak Jembrek, M. (2007) 'Učinak dugotrajne primjene flumazenila na prilagodbu alfa1 beta2 gama2s rekombinantnih GABA-A receptora u kulturi stanica', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Magistarski radovi
Jazvinšćak Jembrek, M. (2000) 'Alfa1 beta2 gama2s rekombinantni GABA-A receptori - model za farmakološka istraživanja', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.
Članstva u profesionalnim udrugama / društvima
- Hrvatsko farmakološko društvo
- Hrvatsko društvo za neuroznanost