dr. sc. Neda Slade
Obrazovanje
1972.-1980. Osnovna škola, Zagreb
1980.-1984. Pedagoški obrazovni centar (V gimnazija, Zagreb)
1984.-1989. Studij molekularne biologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
1989.-1993. Poslijediplomski studij iz molekularne i stanične biologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
1999. obranila doktorsku disertaciju pod naslovom "Gensko liječenje tumora pokretanjem mehanizma samoubojstva stanice genom za timidin kinazu", Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, voditelj prof. dr. sc. Jasminka Pavelić
Projekti
2022. - 2023. donacija Zaklade Adris "Određivanje uloge mikroRNA u stjecanju otpornosti na ciljanu terapiju stanica metastatskog melanoma"
2014. - 2018. "Otkrivanje novih proteinskih intearkcija kao podloga za nove pristupe liječenju melanom ačovjeka - ProNetMel", istraživački projekt HrZZ
2007. – 2013. "Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka“, Ministarstvo znanosti, obrazovanja i športa RH
2007.-2008. “Uloga p73 u kontroli staničnog ciklusa”, bilateralni projekt Ministarstva znanosti, obrazovanja i športa RH i Republike Francuske u okviru hrvatsko-francuskog Programa integriranih akcija "Cogito"
2006.-2007. "p53/p73 Network in chemoresistance. The relevance of dominant - negative p73 isoforms for chemosenstivity“ bilateralni projekt Ministarstva znanosti, obrazovanja i športa RH i Saveznog ministarstva za obrazovanje, znanost i kulturu Republike Austrije za znanstveno-tehničku suradnju Hrvatska – Austija
Nagrade i priznanja
2007. Nagrada „Josip Juraj Strossmayer“ koju dodjeljuje HAZU i Zagrebački velesajam za najbolji izdavački poduhvat u 2007. za sveučilišni priručnik:
“Metode u molekularnoj biologiji” urednice: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade i Dušica Vujaklija, izdavač:Institut Ruđer Bošković, Zagreb, 2007.
2010., 2012., 2018., 2021. Godišnja nagrada ravnatelja za znanstveni rad u području molekularne biomedicine
2021. Zaklada prof.dr.sc. Branimir Jernej - nagrada za najbolji znanstveni rad iz područja biologije, biomedicine, ili neuroznanosti u 2021.g.
Nastava
2003. - 2013.: predavač na Metodološkum tečajevima u biologiji i medicini, u organizaciji Instituta Ruđer Bošković
2006 - danas: Doktorski studij Molekularne bioznanosti Instituta Ruđer Bošković u suradnji sa Sveučilištima u Osijeku i Dubrovniku, suvoditelj kolegija:
Osnove metoda u molekularnoj biologiji i medicini
Metode u molekularnoj biologiji i medicini-praktikum
Tumor supresorski gen p53 i njegovi srodnici
Kontrola staničnog ciklusa, održavanje genomskog integriteta i kancerogeneza
2010.-danas: Poslijediplomski doktorski studij Biologije Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu, suvoditelj kolegija Genetika raka i biologija tumorskih stanica/ od 2015. Biologija tumorskih stanice
Istaknute publikacije
Zaika A.I., Slade N., Erster S., Sansome C., Joseph T.W., Pearl M., Chalas E., Moll U.M. DN p73, a dominant negative inhibitor of wild type p53 and TA p73, is upregulated in human tumors. J Exp Med (2002) 196: 765-780.
Slade N., Zaika A.I., Erster S., Moll U.M. DeltaNp73 stabilizes TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ (2004) 11: 357-360.
Concin N., Becker K., Slade N., Erster S., Mueller-Holzner E., Ulmer H., Daxenbichler G., Zeimet A., Zeillinger R., Marth C., Moll U.M. Transdominant deltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Cancer Res (2004) 64: 2449–2460.
Moll U.M., Slade N. p63 and p73: Roles in Development and Tumor Formation. Mol Cancer Res (2004) 2: 371-386.
Grollman A.P., Shibutani S., Moriya M., Miller F., Wu L., Moll M., Suzuki N., Fernandes A., Rosenquist T., Medverec Z., Jakovina K., Brdar B., Slade N., Turesky R.J., Goodenough A.K., Rieger R., Vukelić M., Jelaković B. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA (2007) 104: 12129-12134.
Slade N., Moll U.M., Brdar B., Zorić A., Jelaković B. p53 mutations as fingerprints for aristolochic acid – an environmental carcinogen in endemic (Balkan) nephropathy. MutatRes/Fund Mol M (2009) 663: 1-6.
Hofstetter G., Berger A., Fiegl H., Slade N., Zorić A., Holzer B., Schuster E., Mobus V.J., Reimer D., Daxenbichler G., Marth C., Zeimet A.G., Concin N.,Zeillinger R. Alternative splicing of p53 and p73: the novel p53 splice variant p53delta is an independent prognostic marker in ovarian cancer. Oncogene (2010) 29:1997-2004.
Slade N., Horvat A. Targeting p73 - A Potential Approach in Cancer Treatment. Curr Pharm Des (2011) 17: 591-602.
Moriya M., Slade N., Brdar B., Medverec Z., Tomić K., Jelaković B., Wu L., Truong S., Fernandes A., Grollman AP. TP53 Mutational signature for aristolochic acid: An environmental carcinogen. Int J Cancer (2011) 129:1532-1536.
Jelaković B., Karanović S., Vuković-Lela I., Miller F., Edwards K., Nikolić J., Tomić K., Slade N., Brdar B., Turesky R., Stipanćić Ž, Dittrich D., Grollman A.P., Dickman K.G. Aristolactam-DNA Adducts in the Renal Cortex: Biomarkers of Environmental Exposure to Aristolochic Acid. Kidney Int (2012) 81:559-567.
Zorić A, Horvat A, Slade N. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis (2013) 34:522-529.
Laganović M, Bendix L, Rubelj I, Kirhmajer Vrkić M, Slade N, Vuković Lela I, Premužić V, Nilsson PM, Jelaković B. Reduced telomere length is not associated with early signs of vascular aging in young men born after intrauterine growth restriction: a paradox? J Hypertens (2014) 32:1613-1619.
Slade N., Zorić A., Horvat B., Vukšić M., Kostović I., Poljak Lj. Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation. Immunobiology (2015) 220: 48-53.
Hanžić N, Horvat A, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N*, Gotić M*. Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Mater Sci Eng C-Mater (2018) 91:486-495. *dopisni autori
Jazvinšćak Jembrek M., Slade N., Hof P.R., Šimić G. The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer's disease. Prog Neurobiol (2018) 168:104-127.
Knezović M., Ozretić P., Bujak M., Pezzè P., Ciribilli Y., Kaštelan Ž., Slade N.*, Hudolin T. The role of p53 isoforms’ expression and p53 mutation status in renal cell cancer prognosis. Urol Oncol – Semin Ori (2019) 37(9):578.e1-578.e10. *dopisni autor
Ozretić P., Hanžić N., Proust B., Sabol M., Trnski D., Radić M., Musani V., Ciribilli Y., Milas I., Puljiz Z., Herak Bosnar M., Levanat S., Slade N. Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Sci Rep (2019) 9(1):12470.
Radić M., Šoštar M., Weber I., Ćetković H., Slade N., Herak Bosnar M. The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage. Int J Mol Sci (2020) 21(7):2363.
Horvat, A.; Tadijan, A.; Vlašić, I.; Slade, N. p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers (2021) 13, 2885.
Karanović S, Ardin M, Tang Z, Tomić K, Villar S, Renard C, Venturini E, Lorch AH, Lee DS, Stipančić Ž, Slade N, Brinar IV, Dittrich D, Karlović K, Borovečki F, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J. Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. Int J Cancer (2022) 150:374–386.
Tadijan A, Precazzini F, Hanžić N, Radić M, Gavioli N, Vlašić I, Ozretić P, Pinto L, Škreblin L, Barban G, Slade N*, Ciribilli Y*. Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers (2021) 13, 5231. * dopisni autori
Radić M, Vlašić I, Jazvinšćak Jembrek M, Horvat A, Tadijan A, Sabol M, Dužević M, Herak Bosnar M*, Slade N*. Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. Int J Mol Sci (2022) 23, 9910. * dopisni autori
Publikacije - autorske knjige
Zbornik
Levanat, Sonja ; Levačić Cvok, Mirela ; Musani, Vesna ; Car, Diana ; Osmak, Maja ; Herak Bosnar, Maja ; Slade, Neda ; Stojanović | Periodicum Biologorum HDIR-2 ''From Bench to Clinic''Second Meeting of the Croatian Association for Cancer research with International Participation. Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2012
Publikacije - Uredničke knjige
Priručnik
Metode u molekularnoj biologiji / Ambriović Ristov, Andreja (ur.). Zagreb: Institut Ruđer Bošković, 2007
Publikacije - prilozi u knjigama
Izvorni znanstveni rad
Moll, Ute M. ; Slade, Neda | The role of p53 and p73 genes in tumor formation // Handbook of Immunohistochemistry and in situ hibridization of human carcinomas. Vol 3: Molecular Genetics: Liver Carcinoma and Pancreatic Carcinoma. | Academic Press, 2005. str. 103-117-x
Slade, Neda ; Pavelić, Jasminka ; Pavelić, Krešimir | Gensko liječenje i kemoprevencija ; Gensko liječenje oboljelih od tumora // Internistička onkologija. | Zagreb: Medicinska naklada, 2004. str. 80-113-x
Erster, Susan ; Slade, Neda ; Moll, Ute M | Mutational analysis of p53 in human tumors. Direct DNA sequencing and SSCP // Methods in Molecular Biology: p53 Protocols. | Totowa (NJ): Humana Press, 2003. str. 219-230-x
Slade, Neda ; Moll, Ute M | Mutational analysis of p53 in human tumors. Immunocytochemistry // Methods in Molecular Biology: p53 Protocols. | Totowa (NJ): Humana Press, 2003. str. 231-243-x
Stručni rad
Slade, Neda | Retrovirusi // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 538-546-x
Slade, Neda | Imunohistokemijsko bojenje tkiva uklopljenih u parafin upotrebom kompleksa peroksidaza-antiperoksidaza // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 608-612-x
Slade, Neda | Imunocitokemijsko bojenje uporabom kompleksa peroksidaza-antiperokisdaza // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 614-616-x
Slade, Neda | Imunofluorescencija // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 616-618-x
Slade, Neda | Imunoprecipitacija // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 627-630-x
Slade, Neda | Koimunoprecipitacija // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 630-x
Ostalo
Slade, Neda | Imunohistokemijsko bojenje smrznutih tkiva uporabom kompleksa peroksidaza-antiperoksidaza // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 612-614-x
Publikacije - prilozi u časopisima
Izvorni znanstveni rad
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Radić, Martina ; Vlašić, Ignacija ; Jazvinšćak Jembrek, Maja ; Horvat, Anđela ; Tadijan, Ana ; Sabol, Maja ; Dužević, Marko ; Herak Bosnar, Maja ; Slade, Neda | Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance // International journal of molecular sciences, 23 (2022), 17; 9910, 19. doi: 10.3390/ijms23179910
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Karanović, Sandra; Ardin, Maude; Tang, Zuojian; Tomić Karla; Villar, Stephanie; Renard, Claire; Venturini, Elisa; Lorch, Adam H.; Lee, Daniel S.; Stipančić, Želimir et al. | Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure // International journal of cancer, 150 (2022), 2; 374-386. doi: 10.1002/ijc.33827
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Horvat, Anđela ; Tadijan, Ana ; Vlašić, Ignacija ; Slade, Neda | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies // Cancers, 13 (2021), 12; 2885, 42. doi: 10.3390/cancers13122885
doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr -
Tadijan, Ana ; Precazzini, Francesca ; Hanžić, Nikolina ; Radić, Martina ; Gavioli, Nicolò ; Vlašić, Ignacija ; Ozretić, Petar ; Pinto, Lia ; Škreblin, Lidija ; Barban, Giulia et al. | Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness // Cancers, 13 (2021), 20; 5231, 25. doi: 10.3390/cancers13205231
doiwww.mdpi.comfulir.irb.hr -
Radić, Martina ; Šoštar, Marko ; Weber, Igor ; Ćetković, Helena ; Slade, Neda ; Herak Bosnar, Maja | The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage // International journal of molecular sciences, 21 (2020), 7; 2363, 19. doi: 10.3390/ijms21072363
doiwww.mdpi.comfulir.irb.hr -
Knezović Florijan, Marijana ; Ozretić, Petar ; Bujak, Maro ; Pezzè, Laura ; Ciribilli, Yari ; Kaštelan, Željko ; Slade, Neda ; Hudolin, Tvrtko | The role of p53 isoforms’ expression and p53 mutation status in renal cell cancer prognosis // Urologic oncologic-seminars and original investigations, 37 (2019), 9; 578e, 10. doi: 10.1016/j.urolonc.2019.03.007
doiwww.sciencedirect.comdoi.org -
Ozretić, Petar ; Hanžić, Nikolina ; Proust, Bastien ; Sabol, Maja ; Trnski, Diana ; Radić, Martina ; Musani, Vesna ; Ciribilli, Yari ; Milas, Ivan ; Puljiz, Zvonimir et al. | Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines // Scientific reports, 9 (2019), 1; 12470, 13. doi: 10.1038/s41598-019-48882-y
doiwww.nature.comwww.nature.comfulir.irb.hr -
Hanžić, Nikolina ; Horvat, Anđela ; Bibić, Juraj ; Unfried, Klaus ; Jurkin, Tanja ; Dražić, Goran ; Marijanović, Inga ; Slade, Neda ; Gotić, Marijan | Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation // Materials science & engineering. C, Biomimetic materials, sensors and systems, 91 (2018), 486-495. doi: 10.1016/j.msec.2018.05.066
doiwww.sciencedirect.com -
Slade, Neda ; Zorić, Arijana ; Horvat, Branka ; Vukšić, Mario ; Kostović, Ivica ; Poljak, Ljiljana | Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation // Immunobiology, 220 (2015), 1; 48-53. doi: 10.1016/j.imbio.2014.09.003
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Laganović, Mario ; Bendix, Laila ; Rubelj, Ivica ; Vrkić Kirhmajer, Majda ; Slade, Neda ; Vuković Lela, Ivana ; Premužić, Vedran ; Nilssonf, Peter M. ; Jelaković, Bojan | Reduced telomere length is not associated with early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox? // Journal of hypertension, 32 (2014), 8; 1613-1620. doi: 10.1097/HJH.0000000000000217
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Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // Carcinogenesis, 34 (2013), 3; 522-529. doi: 10.1093/carcin/bgs370
doiwww.ncbi.nlm.nih.gov -
Zorić, Arijana ; Horvat, Anđela ; Balija, Melita ; Slade, Neda | The Arg72Pro Polymorphism of TP53 in Croatian Population // Croatica chemica acta, 85 (2012), 2; 239-243. doi: 10.5562/cca1866
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Jelaković, Bojan ; Karanović, Sandra ; Vuković-Lela, Ivana ; Miller, Frederick ; Edwards, Karen ; Nikolić, Jovan ; Tomić, Karla ; Slade, Neda ; Brdar, Branko ; Turesky, Robert et al. | Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid // Kidney international, 81 (2012), 6; 559-567. doi: 10.1038/ki.2011.371
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Moriya, Masaaki ; Slade, Neda ; Brdar, Branko ; Medverec, Zvonimir ; Tomić, Karla ; Jelaković, Bojan ; Wu, Lin ; Truong, Sim ; Fernandes, Andrea ; Grollman, Arthur P. | TP53 Mutational signature for aristolochic acid : an environmental carcinogen // International journal of cancer, 129 (2011), 6; 1532-1536. doi: 10.1002/ijc.26077
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Grollman, Arthur P. ; Shibutani, Shinya ; Moriya, Masaaki ; Miller, Frederick ; Wu, Lin ; Moll, Ute ; Suzuki, Naomi ; Fernandes, Andrea ; Rosenquist, Thomas ; Medverec, Zvonimir et al. | Aristolochic acid and the etiology of endemic (Balkan) nephropathy // Proceedings of the National Academy of Sciences of the United States of America, 104 (2007), 29; 12129-12134. doi: 10.1073/pnas.0701248104
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Becker, Kerstin ; Pancoska, Petr ; Concin, Nicole ; Vanden Heuvel, Kelly ; Slade, Neda ; Fischer, Margaret ; Chalas, Eva ; Moll, Ute, M. | Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancer // International journal of oncology, 29 (2006), 4; 889-902. doi: 10.3892/ijo.29.4.889
doiwww.spandidos-publications.com Slade, Neda | Two faces of p73, a member of p53 family // Periodicum biologorum, 106 (2004), 3; 223-231-x
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Concin, Nicole ; Becker, Kirsten ; Slade, Neda ; Erster, Susan ; Mueller-Holzner, Elizabeth ; Ulmer, Hanno ; Daxenbichler, Guenter ; Zeimet, Alain ; Zeillinger, Robert ; Marth, Christian et al. | Transdominant deltaTAp73 Isoforms Are Frequently Up-regulated in Ovarian Cancer. Evidence for Their Role as Epigenetic p53 Inhibitors in Vivo // Cancer research (Baltimore), 64 (2004), 7; 2449-2460. doi: 10.1158/0008-5472.CAN-03-1060
doicancerres.aacrjournals.org Slade, Neda ; Zaika, Alex I. ; Erster, Susan ; Moll, Ute M. | DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation // Cell death and differentiation, 11 (2004), 3; 357-360-x
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Dogan Koružnjak, Jasna ; Grdiša, Mira ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace | Novel Derivatives of Benzo[b]thieno[2,3-c]quinolones: Synthesis, Photochemical Synthesis, and Antitumor Evaluation // Journal of medicinal chemistry, 46 (2003), 21; 4516-4524. doi: 10.1021/jm0210966
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Džolić, Zoran ; Cetina, Mario ; Kovaček, Damir ; Hergold-Brundić, Antonija ; Mrvoš-Sermek, Draginja ; Nagl, Ante ; Slade, Neda ; Pavelić, Krešimir ; Balzarini, Jan ; De Clercq, Erik et al. | Molecular structures and ab initio molecular orbital calculations of the optically active derivatives of 1-aminocyclopropane-1-carboxylic acid // Journal of molecular structure, 655 (2003), 2; 229-241. doi: 10.1016/S0022-2860(03)00255-2
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Džolić, Zoran ; Krištafor, Vedran ; Cetina, Mario ; Nagl, Ante ; Hergold-Brundić, Antonija ; Mrvoš-Sermek, Draginja ; Burgemeister, Thomas ; Grdiša, Mira ; Slade, Neda ; Pavelić, Krešimir et al. | Synthesis, structural studies and biological evaluation of some purine substituted 1- aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes // Nucleosides, nucleotides & nucleic acids, 22 (2003), 4; 373-389. doi: 10.1081/NCN-120022029
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Zaika, Alex I. ; Slade, Neda ; Erster, Susan H. ; Sansome, Christine ; Joseph, Troy W. ; Pearl, Michael ; Chalas, Eva ; Moll, Ute M. | Delta Np73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors // The Journal of experimental medicine, 196 (2002), 6; 765-780. doi: 10.1084/jem.20020179
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Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Kresimir ; Karminski-Zamola, Grace | Synthesis, photochemical synthesis and antitumor evaluation of novel derivatives of thieno(3', 2':4, 5)thieno(2, 3-c)quinolones // Chemical and pharmaceutical bulletin, 50 (2002), 5; 656-660. doi: 10.1248/cpb.50.656
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Slade, Neda ; Galetić, Ivana ; Kapitanović, Sanja ; Pavelić, Jasminka | The efficacy of retroviral herpes simplex virus thymidine kinase gene transfer and ganciclovir treatment on the inhibition of melanoma growth in viro and in vivo // Archives of dermatological research, 293 (2001), 10; 484-490
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Kapitanović, Sanja ; Radošević, Senka ; Slade, Neda ; Kapitanović, Milan ; Anđelinović, Šime ; Ferenčić, Željko ; Tavassoli, Mahvash ; Spaventi, Šime ; Pavelić, Krešimir ; Spaventi, Radan | Expression of erbB-3 protein in colorectal adenocarcinoma: correlation with poor survival // Journal of Cancer Research and Clinical Oncology, 126 (2000), 4; 205-211. doi: 10.1007/s004320050034
doilink.springer.com Slade, Neda ; Štorga-Tomić, Danijela ; Birkmayer, George D. ; Pavelić, Krešimir ; Pavelić, Jasminka | Effect of extracellular NADH on human tumor cell proliferation // Anticancer Research, 19 (1999), 5355-5360-x
Pavelić, Jasminka ; Slade, Neda ; Galetić, Ivana ; Pavelić, Krešimir | Gensko liječenje: načela, dometi i perspektive // Pharmaca, 36 (1998), 151-170
Slade, Neda ; Kuzmić, Ivana ; Poljak, Ljiljana ; Krušlin, Božo ; Pavelić, Krešimir ; Pavelić, Jasminka | Inverse relation between type IV collagenase and TGF-ß1 in human endometrial carcinoma // Tumordiagnostik & Therapie, 16 (1995), 6; 230-231-x
Slade, Neda ; Pavelić, Jasminka ; Krušlin, Božo ; Pavelić, Krešimir | Type IV collagenase in squamous cell and basal cell skin carcinomas // Archives of dermatological research, 287 (1995), 5; 512-514
Knežević, Vladimir ; Spaventi, Radan ; Poljak, Ljiljana ; Slade, Neda ; Švajger, Anton ; Pavelić, Krešimir | P185neu is expressed in zolk sac during postimplantation development // Journal of anatomy, 185 (1994), 1; 181-187
Sever, Zvjezdana ; Pavelić, Jasminka ; Levanat, Sonja ; Spaventi, Radan ; Slade, Neda ; Jelić, Ivan ; Baltić, Vladimir ; Pavelić, Ljubomir ; Čabrijan, Tomislav ; Časl, Tino-Martin et al. | Insulin-related substances in human solid tumors // Tumordiagnostik & Therapie, 13 (1992), 54-59
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Slade, Neda ; Levanat, Sonja ; Spaventi, Šime ; Pavelić, Krešimir | Collagenase derived from human fibrosarcoma is responsible for degradation of basement membranes // International journal of experimental pathology, 72 (1991), 6; 715-724
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Pavelić, Krešimir ; Despot Slade, Neda ; Levanat, Sonja ; Časl, Tino | Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes // Biological Chemistry Hoppe-Seyler, 371 (1990), 687-692. doi: 10.1515/bchm3.1990.371.2.687
doiwww.degruyter.com
Pregledni rad (znanstveni)
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Vlašić, Ignacija ; Horvat, Anđela ; Tadijan, Ana ; Slade, Neda | p53 Family in Resistance to Targeted Therapy of Melanoma // International journal of molecular sciences, 24 (2023), 1; 65, 16. doi: 10.3390/ijms24010065
doiwww.mdpi.comfulir.irb.hr -
Ravlić, Sanda ; Škrobot Vidaček, Nikolina ; Nanić, Lucia ; Laganović, Mario ; Slade, Neda ; Jelaković, Bojan ; Rubelj, Ivica | Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood // Mechanisms of ageing and development, 174 (2018), 55-62. doi: 10.1016/j.mad.2017.08.014
doiwww.sciencedirect.com -
Jazvinšćak Jembrek, Maja ; Slade, Neda ; Hof, Patrick R. ; Šimić, Goran | The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease // Progress in neurobiology, 168 (2018), 104-127. doi: 10.1016/j.pneurobio.2018.05.001
doiwww.sciencedirect.com -
Slade, Neda ; Horvat, Anđela | Targeting p73 - a potential approach in cancer treatment // Current pharmaceutical design, 17 (2011), 6; 591-602. doi: 10.2174/138161211795222621
doiwww.ingentaconnect.com -
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi // Medicina Fluminensis, 46 (2010), 2; 135-143
hrcak.srce.hr -
Slade, Neda ; Zorić, Arijana ; Horvat, Anđela | The p53/p63/p73 family of proteins - the focus on isoforms and mutants in cancer // Periodicum biologorum, 112 (2010), 4; 425-432
hrcak.srce.hr -
Slade, Neda ; Moll, Ute M. ; Brdar, Branko ; Zorić, Arijana ; Jelaković, Bojan | p53 mutations as fingerprints for aristolochic acid - an environmental carcinogen in endemic (Balkan) nephropathy // Mutation research, 663 (2009), 1-2; 1-6. doi: 10.1016/j.mrfmmm.2009.01.005
doiwww.sciencedirect.com -
Moll, Ute M. ; Slade, Neda | p63 and p73: Roles in Development and Tumor Formation // Molecular cancer research, 2 (2004), 7; 371-386
aacrjournals.org Slade, Neda | Viral vectors in gene therapy // Periodicum biologorum, 103 (2001), 2; 139-143
Kratko priopćenje
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Hofstetter, Gerda ; Berger, Astrid ; Fiegl, Heidi ; Slade, Neda ; Zorić, Arijana ; Holzer, Barbara ; Schuster, Eva ; Mobus, Volker J. ; Reimer, Daniel ; Daxenbichler, Günter et al. | Alternative splicing of p53 and p73: the novel p53 splice variant p53d is an independent prognostic marker in ovarian cancer // Oncogene, 29 (2010), 13; 1997-2004. doi: 10.1038/onc.2009.482
doiwww.nature.com
Publikacije - prilozi sa skupa (u zborniku)
Sažetak izlaganja sa skupa
Slade, Neda ; Vukšić, Mario ; Kostović, Ivica ; Poljak, Ljiljana | Jak-1/Smads signaling dependent genes expression adn brain repair reaction // EMBO Workshop, Common Regulatory Mechanisms in Haemopoiesis and Neurogenesis. | Heidelberg, 2007. str. 35-x
Slade, Neda ; Moll, Ute ; Erster, Susan ; Wu, Li ; Grollman, Arthur P. | DEFINING MOLECULAR PATHWAYS IN ENDEMIC NEPHROPATHY -ASSOCIATED UPPER TRACT UROTHELIAL CARCINOMA // Collegium Antropologicum. | Zagreb, 2006. str. 63-x
Zorić, Arijana ; Pavelić, Jasminka ; Slade, Neda | p53 isoforms and p73 activity // Congres of the Croatian Society of Biocehemistry and Molecular Biology, Book of Abstracts. | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2006. str. 77-x
Slade, Neda ; Zaika, Alex I. ; Erster, Susan ; Moll, Ute M. | Delta Np73 stabilizes TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation // 2nd p73/p63 International Workshop. | 2004. str. 67-x
Slade, Neda ; Zaika, Alex I. ; Moll, Ute M. | DeltaNp73 stabilizes TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation // FEBS Lecture Course on Cellular Signaling & 4th Dubrovnik Signaling Conference. | Zagreb, 2004. str. 215-x
Slade, Neda | Molekularno usmjereno liječenje tumora mozga // 2. Kongres Hrvatskog onkološkog društva HLZ-a s međunarodnim sudjelovanjem. | Zagreb: Studio Hrg, 2004. str. 61-x
Slade, Neda | The role of p73, p53 gene homologue, in tumors // Periodicum Biologorum, Fourth Croatian Congress of Pharmacology. | Zagreb: Hrvatsko prirodoslovno društvo, 2004. str. 55-x
Krištafor, Vedran ; Džolić, Zoran ; Cetina, Mario ; Nagl, Ante ; Hergold-Brundić, Antonija ; Mrvoš- Sermek, Draginja ; Burgemeister, Thomas ; Grdiša, Mira ; Slade, Neda ; Pavelić, Krešimir et al. | Synthesis, Structural Studies And Biological Evaluation Of The Purine Substituted 1- Aminocyclopropane-1-Carboxylic Acids And 1- Amino- 1-Hydroxymethylcyclopropanes // XVIII hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo ; Hinus, 2003. str. 79-79
Slade, Neda ; Zaika, Alex ; Moll, Ute M. | DNp73 stabilizes TAp73 protein // 19th Annual Meeting on Oncogenes. | 2003
Slade, Neda ; Zaika, Alex I. ; Moll, Ute M. | DNp73 stabilizes TAp73 protein // 45 godina molekularne biologije u Hrvatskoj, 50 godina dvostruke uzvojnice. | 2003. str. 37-x
Zaika, Alex I. ; Slade, Neda ; Erster, Susan ; Sansome, Christine ; Joseph, Troy W. ; Pearl, Michael ; Chalas, Eva ; Moll, Ute M. | Delta N p73, a dominant negative inhibitor of wild type p53 and TA p73, is upregulated in human tumors // 11th International p53 Workshop. | 2002
Komar, Arijana ; Slade, Neda ; Pavelić, Jasminka ; Štorga-Tomić, Danijela ; Birkmayer GD ; | Extracellular NADH and NADH+ downregulate the proliferation of human tumor cell lines // 3rd International Conference on Signal Transduction. | Zagreb, 2002. str. 115-116-x
Džolić, Zoran ; Kristafor, Vedran ; Cetina, Mario ; Nagl, Ante ; Hergold-Brundić, Antonija ; Mrvoš-Sermek, Draginja ; Slade, Neda ; Pavelić, Krešimir ; Balzarini, Jan ; De Clercq, Erik et al. | The Novel Spacered Cyclopropyl Nucleoside Analogues : Synthesis, Structural Studies And Biological Evaluation Of The Purine Supstituted 1-Aminocyclopropane-1-Carboxylic Acids And 1- Amino-1-Hydroxymethylcyclopropanes // XV International Round Table "Nucleosides, Nucleotides & Nucleic Acids". | Leuven, 2002. str. P-22-P-22
Komar, Arijana ; Slade, Neda ; Pavelić, Jasminka ; Štorga-Tomić, Danijela ; Birkmayer, D.Georg | Extracellular NADH and NAD+ downregulate the proliferation of human tumor cell lines // Program&Abstract. | Zagreb, 2002. str. 115-116-x
Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace | Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones // Knjiga sinopsisa. | Barcelona: Drugs of the Future, 2002. str. 209-209-x
Raić-Malić, Silvana ; Slade, Neda ; Svedružić, Draženka ; Gazivoda, Tatjana ; Nagl, Ante ; Hergold-Brundić, Antonija ; Balzarini, Jan ; De Clercq, Erik ; Spaventi, Radan ; Pavelić, Krešimir et al. | Synthesis and biological activities of novel pyrimidine derivatives of 4,5-didehydro-5,6- dideoxy-L-ascorbic acid // 2nd International Conference on Signal transduction. | 2000. str. 111-111
Slade, Neda | Vectors in Gene Therapy // Molecular Medicine-Signal Transduction (Course No. 5). | 2000
Slade, Neda ; Grdiša, Mira ; Dogan-Koružnjak, Jasna ; Karminski-Zamola, Grace ; Zamola, Branimir ; Pavelić, Krešimir | Antitumor activity of new heteropolycyclic substances from the series of benzo-thieno-quinolones and thieno-thienyl-quinolones // 2nd International Conference on Signal Transduction ICST, Program and Abstracts. | Zagreb, 2000. str. 115-115-x
Slade, Neda | Gene Therapy of Monogenic Diseases // Molecular Medicine-Signal Transduction (Course No. 4). | 1998
Slade, Neda | Gene Therapy // Molecular Medicine-Signal Transduction (Course No. 4).. | 1998
Izvorni znanstveni rad
Slade, Neda ; Zorić, Arijana ; Horvat, Branka ; Vukšić, Mario ; Kostović, Ivica ; Poljak, Ljiljana | JAK-1/Smad signaling dependent genes expression associated with neurogenic to astrogliogenic transition point of brain development // The Proceedings of the 6th Joint Meeting of the International Cytokines Society (ICS), International Society of Interferon and Cytokine Research (ISICR) and the European Cytokine Society (ECS). | Bologna: Medimond International Proceedings, 2006. str. 1-5
Publikacije - prilozi sa skupa (u časopisu)
Sažetak izlaganja sa skupa
Slade, Neda ; Walting, Diane ; Kostović, Ivica ; Poljak, Ljiljana | JAK-1/Smad signaling dependent genes expression associated with the neurogenic to astrogliogenic transition point of brain development // European cytokine network, 2006. str. 1-5-x
Publikacije - prilozi sa skupa (neobjavljeni)
Neobjavljeni prilog sa skupa
Slade, Neda ; Levanat Sonja | TGF β and collagenase type IV in tumor invasion // New Aspects in Molecular Medicine | Zagreb, Hrvatska, 19.02.1993-19.02.1993
Publikacije - ocjenski radovi
Doktorski rad
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Hanžić, Nikolina | Funkcionalne interakcije p53 i obitelji proteina p53/p73, NME i GLI u melanomu čovjeka / Slade, Neda (mentor). | Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, 2018
rektorat.unios.hr Horvat, Anđela | Utjecaj proteina ΔNp73α na kontrolu staničnog ciklusa nakon oštećenja DNA u stanicama čovjeka / Slade, Neda ; Dulić, Vjekoslav (mentor). | Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, 2015
Tučkar, Neven | Utjecaj izoformi gena p73 na metiliranja DNA u stanicama raka / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2012
Zorić, Arijana | Utjecaj mutiranih oblika i izoformi gena p53 na aktivnost gena p73 u stanicama tumora / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2009
Slade, Neda | Gensko liječenje tumora pokretanjem mehanizma samoubojstva stanice genom za timidin kinazu / Pavelić, Jasminka (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1999
Diplomski rad (sveučilišni)
Borić, Ana | Ekspresija izoformi proteina p53 i p73 u staničnim linijama sarkoma mekih tkiva čovjeka / Slade, Neda (mentor); Ozretić, Petar (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2019
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Grižančić, Lana | Interakcije između proteina Itch, p63/p73 i mutiranog p53 u tumorskim / Slade, Neda (mentor); Hanžić, Nikolina (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2018
urn.nsk.hr Proust, Bastien | The expression profile of p53 isoforms in healthy and melanoma tissues / Slade, Neda (mentor). | Orléans, 2016
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Petrović, Lidija | Ekspresija izoformi proteina p53 i p73 u stanicama melanoma čovjeka nakon izlaganja γ-zračenju / Slade, Neda (mentor); Hanžić, Nikolina (neposredni voditelj) . | Zagreb, Farmaceutsko-biokemijski fakultet, 2016
urn.nsk.hr Pfeiffer, Anamarija | Stvaranje heterotetramera između proteina p63 i mutiranih oblika p53 u stanicama tumora čovjeka / Slade, Neda; Marijanović, Inga (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2014
Kovačević, Marina | Transkripcijska aktivnost izoformi proteina p53 / Slade, Neda (mentor); Slade, Neda (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2011
Rambrot, Dina | Utjecaj pojačane ekspresije gena p73 na preživljenje stanica nakon oštećenja DNA / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2008
Runje, Anđela | Differences in stability of p53 tumor-suppressor protein isoforms / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007
Publikacije - druge vrste radova
Ostalo
Levanat, Sonja ; Levačić Cvok, Mirela ; Musani, Vesna ; Car, Diana ; Osmak, Maja ; Herak Bosnar, Maja ; Slade, Neda ; Stojanović | Periodicum Biologorum HDIR-2 ''From Bench to Clinic''Second Meeting of the Croatian Association for Cancer research with International Participation / Vitale, Branko (ur.). Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2012. 87
Članstva u profesionalnim udrugama / društvima
Hrvatsko društvo za istraživanje raka (HDIR, podružnica EACR-a) član Izvršnog odbora, od 2021. dopredsjednica
Hrvatsko društvo biokemičara i molekularnih biologa
Hrvatsko biološko društvo
Hrvatsko društvo za humanu genetiku
Mentorstva
Voditelj doktorskih disertacija:
Arijana Zorić, "Utjecaj mutiranih oblika i izoformi gena p53 na aktivnost gena p73 u stanicama tumora", Prirodoslovno-matematički fakultet, Zagreb, 2009.
Neven Tučkar, "Uloga izoformi gena p73 na metiliranja DNA u stanicama raka”, Prirodoslovno-matematički fakultet, Zagreb, 10.12.2012.
Anđela Horvat, " Utjecaj proteina ΔNp73α na kontrolu staničnog ciklusa nakon oštećenja DNA u stanicama čovjeka“, Molekularne bioznanosti, Sveučilište JJ Strossmajera u Osijeku, Zagreb 22.05.2015.
Nikolina Hanžić, „Funkcionalne interakcije p53 i obitelji proteina p53/p73, NME i GLI u melanomu čovjeka“, Molekularne bioznanosti, Sveučilište JJ Strossmajera u Osijeku, Zagreb 11.10.2018.
Voditelj diplomskih radova:
Anđela Runje, "Razlike u stabilčnosti izoformi tumor supresorskog proteina p53", Prirodoslovno-matematički fakultet, 2007.
Dina Rambrot, "Utjecaj pojačane ekspresije gena p73 na preživljenje stanica nakon oštećenja DNA", Prirodoslovno-matematički fakultet, 2008.
Marina Kovačević, "Transkripcijska aktivnost izoformi proteina p53", Prirodoslovno-matematički fakultet, Zagreb, 2011.
Anamarija Pfeifer, „Stvaranje heterotetramera između proteina p63 i mutiranih oblika p53 u stanicama tumora čovjeka“, Prirodoslovno-matematički fakultet, Zagreb, 2014.
Lidija Petrović, „Ekspresija izoformi proteina p53 i p73 u stanicama melanoma čovjeka nakon izlaganja ɣ-zračenju“, Farmaceutsko-biokemijski fakultet, Zagreb, 2016.
Bastien Proust, „The expression profile of p53 isoforms in healthy and melanoma tissues“, University of Orléans, Orléans, Francuska, 2016.
Lana Grižančić, „Interakcije između proteina ITCH, p63/p73 i mutiranog p53 u tumorskim stanicama“, Prirodoslovno-matematički fakultet, Zagreb, 2018.
Ana Borić, „Ekspresija izoformi proteina p53 i p73 u staničnim linijama sarkoma mekih tkiva čovjeka“, Prirodoslovno-matematički fakultet, Zagreb, 2019.
Studijski boravci u inozemstvu:
1999. Stipendija Republike Francuske, CNRS Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CERVI, Hôpital de la Pitié, Pariz, Francuska
2001.-2003. poslijedoktorsko usavršavanje, Department of Pathology, SUNY at Stony Brook, NY, SAD
Udžbenici i knjige:
Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: immunocytochemistry. U: Methods in Molecular Biology: p53 Protocols, ur. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press, 234: 231-243.
Erster S., Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP. U: Methods in Molecular Biology: p53 Protocols, ur. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press, 234:219-230.
Slade N., Pavelić J., Pavlić K. (2004) Osnovna načela sistemskog liječenja zloćudnih tumora - Gensko liječenje i kemoprevencija. U: Internistička onkologija, ur. Mršić-Krmpotić Z., Roth A i sur. Medicinska naklada, Zagreb, 80-113.
Moll U.M., Slade N. (2005) The role of p53 and p73 genes in tumor formation. U: Handbook of Immunohistochemistry and in situ hibridization of human carcinomas. Vol 3: Molecular Genetics: Liver Carcinoma and Pancreatic Carcinoma, ur. Hayat MA. Academic Press, USA, 103-117.
Urednik i autor nekoliko poglavlja u Sveučilišnom priručniku:
“Metode u molekularnoj biologiji” urednice: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade i Dušica Vujaklija, izdavač:Institut Ruđer Bošković, Zagreb, 2007.
Sudjelovanje u organizaciji međunarodnih simpozija:
1st International Conference on Signal Transduction, 08.-12. 10.1998, Cavtat-Dubrovnik
2nd International Conference on Signal Transduction, 26.-31. 10. 2000, Cavtat-Dubrovnik
"50 godina molekularne biologije u Hrvatskoj" 20.-21. 11. 2008, Zagreb
HDIR-1 - 1st Meeting with International Participation “From Bench to Clinic”, Zagreb, 11. 11. 2010, Zagreb
HDIR-2 - 2nd Meeting with International Participation “From Bench to Clinic”, Zagreb, 8.-9. 11. 2012, Zagreb - član znanstvenog odbora
HDIR-3 - 3rd Meeting with International Participation “From Bench to Clinic”, Zagreb, 6.-7. 11. 2014, Zagreb - član znanstvenog odbora
HDIR-4 - 4th Meeting with International Participation “From Bench to Clinic”, Zagreb, 3.-4. 11. 2016, Zagreb - član znanstvenog odbora
„10th International congress of the NDP kinase/NM23/AWD gene family“, međunarodni skup, Dubrovnik 2016., član organizacijskog odbora (https://ndpk2016.irb.hr/)
HDIR-5 – 5th Meeting with International Participation “Translating Science to Medicine – Targets and Therapeutics”, Zagreb, 8.-10.11.2018. - član znanstvenog odbora
„International p53/p63/p73 Isoforms Workshop“, međunarodni skup, Dubrovnik 2019. član znanstvenog odbora i glavni organizator skupa (https://p53p63p73isoforms.irb.hr/)
HDIR-6 – 6th Meeting with International Participation “Targeting Cancer””, Zagreb, 10.-12.11.2022. član znanstvenog odbora
Povjerenstva:
Od 2021. članica Nacionalnog povjerenstva za liječenje vođeno sveobuhvatnim genskim profiliranjem
2013.- 2018. članica Povjerenstva za predevaluaciju prijedloga za Europske projekte, Institut Ruđer Bošković
2008.-danas član Odbora za genomiku i proteomiku u onkologiji pri Hrvatskoj akademiji znanosti i umjetnosti
2014. član Panela za vrednovanje istraživačkih i projektnih prijedloga zaprimljenih na natječaje Hrvatske zaklade za znanost - Uspostavni istraživački projekti (UIP-09-2014) i Istraživački projekti (IP-09-2014)