dr. sc. Sanja Tomić
Institut Ruđer Bošković
Bijenička 54
HR-10000 Zagreb
Projekti
Projects since 2013
Coordinator
2007 – 2013. MZOŠ project „Computational study of bio-macromolecules and development of new
algorithms‟ (098-1191344-2860)
2012 – 2015 'Alexander von Humboldt, Research Group Linkage' programm: 'Study of plant
enzymes from metallopeptidase families M20 and M49‟
2014 – 2017 HRZZ project: 'Flexibility, activity and structure correlations in the dipeptidyl
peptidase III family' (01.07.2014-30.06.2017)
2016 – 2017 Bilateral project with Austria (Karl Gruber, TU, Graz), 'An Interdisciplinary
Study on Atypical Dipeptidyl Peptidases III (DPPs III) Structure and Dynamics '.
2018 – 2022 HRZZ project: 'Biological relevance of dipeptidyl peptidase III and its impact on
human health' (IP-2018-01-2936)
Paricipant
2013-2016: FP7-REGPOT-2012-2013-1 „Enhancement of the InnovationPotential in SEE
through new Molecular Solutions in Research and Development‟
Nagrade i priznanja
Awards
1991-1992. NUFFIC fellowship, Rijkuniversiteit, Utrecht, Netherland
1996-1998 Alexander von Humboldt research fellowship
2012. RuĊer Bošković Institute award for scientific publication
Nastava
“Biomacromolecules Crystalography and Modeling” (Luić, Tomić,) Faculty of Natural Sciences and
Mathematics, at University of Zagreb, Graduate study, “Molecular modelling of biomacromolecules”
(Faculty of Natural Sciences and Mathematics, at University of Zagreb, University of Split and
University of Osjek, PhD studies in Biochemistry & Biophysics, “Computational Chemistry” at
University of Rijeka, Department for Biotehnology, Doctorate study)
Publikacije - Uredničke knjige
Zbornik radova s konferencije
The 5th Central European Conference - Chemistry towards Biology / Abramić, Marija ; Maksić, Zvonimir ; Salopek-Sondi, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2010
The 3rd Adriatic Meeting on Computational Solutions in Life Sciences : book of abstracts / Babić, Darko ; Došlić, Nadja ; Smith, David et al. (ur.). Zagreb: Institute of Computational Life Sciences (ICLS), 2009
The 2nd Opatija Meeting on Computational Solutions in Life Sciences : book of abstracts / Babić, Darko ; Došlić, Nadja ; Smith, David et al. (ur.). Zagreb: Institute of Computational Life Sciences (ICLS), 2007
Publikacije - prilozi u knjigama
Izvorni znanstveni rad
Tomić, Sanja | Enantioselectivity of Burkholderia cepacia lipase towards primary and secondary alcohols: molecular modelling and 3D QSAR analysis // Designing drugs and crop protectants: processes, problems and solutions. | Oxford: Wiley-Blackwell, 2003. str. 326-328-x
Tomić, Sanja ; Nillson, Lennart ; Wade, Rebecca | Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding // Molecular Modeling and Prediction of Bioactivity. | New York (NY): Kluwer Academic Publishers ; Plenum Publishers, 2000. str. 269-270-x
Publikacije - prilozi u časopisima
Izvorni znanstveni rad
Tomić, Sanja ; Dobovičnik, Vladimir ; Šunjić, Vitomir ; Kojić-Prodić, Biserka | Enantioselectivity of the Pseudomonas cepacia lipase towards 2-methyl-3-(or 4)-arylalkanols: an approach based on stereoelectronic theory and the molecular modeling // Croatica chemica acta, 74 (2001), 343-357-x
Luić, Marija ; Tomić, Sanja ; Leščić, Ivana ; Ljubović, Edina ; Šepac, Dragan ; Šunjić, Vitomir ; Vitale, Ljubinka ; Saenger, Wolfram ; Kojić-Prodić, Biserka | Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study. // European journal of biochemistry, 268 (2001), 14; 3964-3973-x
Tomić, Sanja ; Nillson, Lennart ; Wade, Rebecca | Nuclear receptor-DNA binding specificity : a combine and Free-Wilson QSAR ananlysis // Journal of medicinal chemistry, 43 (2000), 9; 1780-1792-x
Kojić-Prodić, Biserka ; Magnus, Volker ; Antolić, Snježana ; Tomić, Sanja ; Salopek-Sondi, Branka | Structure/activity correlations for auxins // Acta botanica Croatica, 58 (1999), 27-37
Ramek, Michael ; Tomić, Sanja | Quantum chemical conformational analysis of the auxin phytohormone 4-methyl-3-indole acetic acid // International journal of quantum chemistry, 75 (1999), 6; 1003-1008-x
Tomić, Sanja ; Ramek, Michael ; Kojić-Prodić, Biserka | Combined Ab Initio SCF and molecular mechanics studies of propionic and isobutyric acids and their indole derivatives related to the phytohormone auxin (Indole-3-acetic acid). // Croatica chemica acta, 71 (1998), 511-525-x
Tomić, Sanja ; Gabdoulline, Razif R. ; Kojić-Prodić, Biserka ; Wade, Rebecca C. | Classification of auxin plant hormones by interaction property similarity indices. // Journal of computer-aided molecular design, 12 (1998), 63-79-x
Ramek, Michael ; Tomić, Sanja | Ab Initio RHF investigation of mono- and dihalogenated indole-3-acetic acid (IAA) phytohormones. // Journal of molecular structure. Theochem, 454 (1998), 167-173-x
Ramek, Michael ; Tomić, Sanja | RHF conformational analysis of the auxin phytohormones n-ethyl-indole-3-acetic acid (n=4, 5, 6). // International journal of quantum chemistry, 70 (1998), 6; 1169-1175-x
Tomić, Sanja ; Gabdoulline, Razif R. ; Kojić-Prodić, Biserka ; Wade, Rebecca C. | Classification of auxin related compounds based on similarity of their interaction fields: extension to a new set of compounds. // Internet journal of chemistry, 1 (1998), 26-x
Antolić, Snježana ; Kojić-Prodić, Biserka ; Magnus, Volker ; Salopek, Branka ; Tomić, Sanja | Structure-activity correlations for ring-alkylated derivatives of indole-3-acetic acid // Plant physiology, 114 (1997), 3; 158-158-x
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Ramek, Michael ; Tomić, Sanja ; Kojić-Prodić, Biserka | Comparative ab initio SCF conformational study of phytohormones (auxins) 4-chloro-indole-3-acetic acid and indole-3-acetic acid // International journal of quantum chemistry, 60 (1996), 8; 1727-1733. doi: 10.1002/(SICI)1097-461X(1996)60:8<1727::AID-QUA1>3.0.CO;2-%23
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Antolić, Snježana ; Kojić-Prodić, Biserka ; Tomić, Sanja ; Nigović, Biljana ; Magnus, Volker ; Cohen, Jerry D. | Structural studies on monofluorinated derivatives of the phytohormone indole-3-acetic acid (auxin) // Acta crystallographica. Section B, Structural science, 52 (1996), 4; 651-661. doi: 10.1107/S0108768195016302
doiscripts.iucr.org
Pregledni rad (znanstveni)
Ljubović, Edina ; Tomić, Sanja ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Current Approach to Study of Biocatalytic Reactions: Experiment and Molecular Modeling of Lipase Catalysed Reactions // Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 50 (2001), 3; 139-156
Publikacije - prilozi sa skupa (u zborniku)
Sažetak izlaganja sa skupa
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Tomić, Antonija; Tomić, Sanja | Understanding Binding and Hydrolysis of Neuropeptides in the Active Site of Human Dipeptidyl Peptidase III // Computational Chemistry Day 2022 : book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2022. str. 19-19
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Matić, Antonia ; Karačić, Zrinka ; Tomić, Antonija ; Brkić, Hrvoje ; Tomić Sanja | Dipeptidyl peptidase iii inhibition tests by metal dications // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge. | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2022. str. 105-105
congress2022.hdbmb.hr Kekez, Ivana ; Matić, Sara ; Tomić, Sanja ; Matković-Čalogović, Dubravka | Binding of peptide mimicking the ETGE loop of dipeptidyl peptidase III to the Kelch domain of Keap1 // The twenty-eighth Croatian-Slovenian Crystallographic Meeting : Book of Abstracts. | Zagreb, 2022. str. 8-8
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Matovina, Mihaela ; Tomašić Paić, Ana ; Barbarić, Lea ; Brkić, Hrvoje ; Tomić, Sanja ; Marinović, Ivana | Study of the interaction of dipeptidyl peptidase 3 and SH2 domain-containing protein 3C // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge. | Zagreb: Croatian Society of Biochemistry and Molecular, 2022. str. 107-107
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Tomić, Sanja ; Karačić, Zrinka ; Tomić, Antonija ; Brkljačić, Lidija ; Šupljika, Filip | Neuropeptides - substrates of dipeptidyl peptidase III // From Science to Knowledge. | Zagreb: Hrvatsko Društvo za Biotehnologiju, 2022. str. 151-151
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Tomić, Antonija ; Karačić, Zrinka ; Šupljika, Filip ; Tomić, Sanja | Computational modelling an aid to understand binding and hydrolysis of neuropeptides in the active site of human DPP III // Book of abstracts of the 1st Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1). | 2022. str. 196-196
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Tomić, Antonija ; Tomić, Sanja | Computational study of the human DPP III catalyzed peptide hydrolysis - difference between „good“ and „slow“ substrate // Math/Chem/Comp 2022 and 33rd MC2 Conference : Book of Abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2022. str. 24-24
mcc.hkd.hr Zonjić, Iva ; Tumir, Lidija Marija ; Šupljika, Filip ; Crnolatac, Ivo ; Racane, Livio ; Tomić, Sanja ; Radić Stojković, Marijana | Interactions of benzothiazole ligands with DNA:RNA hybrids and triplex structures // IV. SIMPOZIJ SUPRAMOLEKULSKE KEMIJE Supramolecular Chemistry 2021. | Zagreb, 2021. str. 1-1
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Tomić, Antonija ; Tomić, Sanja | Understanding the human DPP iii substrate specificity : QM/MM and MD calculations // Math/Chem/Comp 2021 : 32nd MC2 Conference : book of abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 42-42
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Agić, Dejan ; Šubarić, Domagoj ; Karnaš, Maja ; Komar, Mario ; Karačić, Zrinka ; Tomić, Sanja ; Bešlo, Drago ; Rastija, Vesna ; Molnar, Maja | Interactions of human dipeptidyl petidase III with coumarinyl Schiff bases // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 157-157
27hskiki.hkd.hr Zonjić, Iva ; Tumir, Lidija Marija ; Šupljika, Filip ; Crnolatac, Ivo ; Racané, Livio ; Tomić, Sanja ; Radić Stojković Marijana | Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands // 27th Croatian Meeting of Chemists and Chemical Engineers. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 44-44
Zonjić, Iva ; Tumir, Lidija-Marija ; Šupljika, Filip ; Crnolatac, Ivo ; Racane, livio ; Tomić, Sanja ; Radić Stojković, Marijana | Recognition of DNA:RNA hybrid and triplex structures by a series of benzothiazole ligands. | 2021. str. 1-1
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Matić, Antonia ; Karačić, Zrinka ; Tomić, Antonija ; Brkić, Hrvoje ; Tomić, Sanja | Ispitivanja inhibicije dipeptidil peptidaze III metalnim dikationima // Knjiga sažetaka - 18. Ružičkini dani: Danas znanost - Sutra industrija. | Zagreb : Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2020. str. 78-78
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Tomić, Sanja ; Karačić, Zrinka ; Brkljačić, Lidija ; Tomašić Paić, Ana ; Ćehić, Mirsada ; Matovina, Mihaela | Uloga dipeptidil peptidaze III u regulaciji boli // Knjiga sažetaka - 18. Ružičkini dani: Danas znanost - Sutra industrija. | Zagreb : Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2020. str. 134-134
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Agić, Dejan ; Karnaš, Maja ; Šubarić, Domagoj ; Komar, Mario ; Karačić, Zrinka ; Tomić, Sanja ; Molnar, Maja | Inactivation of human dipeptidyl peptidase III by quinazolinone derivatives // 18th International conference Ružička Days “Today Science – Tomorrow Industry” : Book of Abstracts / Jukić, Ante (ur.). | Zagreb, Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Osijek, 2020. str. 124-124
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Tomin, Marko ; Tomić, Sanja | Human DPP III - Keap1 interactions // The 3rd COST-sponsored ARBRE-MOBIEU plenary meeting Book of Abstracts. | Zagreb: Institut Ruđer Bošković ; Hrvatsko biofizičko društvo, 2019. str. 134-135
arbre-mobieu.eu Bistrović, Andrea ; Stolić, Ivana ; Krstulović, Luka ; Taylor, C. Martin ; Kelly, M. John ; Tomić, Sanja ; Bajić, Miroslav ; Raić-Malić, Silvana | Novel symmetric bis-benzimidazoles: synthesis, DNA/RNA binding and antitrypanosomal activity // Knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 145-145
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Tomin, Marko ; Tomić, Sanja | Human DPP III - Keap1 interactions // Computational Chemistry Day 2019 Book of Abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2019. str. 24-24
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Tomić, Antonija ; Horvat, Gordan ; Ramek, Michael ; Agić, Dejan ; Brkić, Hrvoje ; Tomić, Sanja | Development of new zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases // Computational Chemistry Day 2019 :Book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2019. str. 3-3
ccd19.pharma.hr Tomin, Marko ; Tomić, Sanja | Dipeptidyl peptidase III from a mesophilic and thermophilic bacterium – similarities and differences // The 14th Greta Pifat Mrzljak International School of Biophysics, ABC of Physics of Life: Book of abstracts. | Zagreb: Institut Ruđer Bošković ; Hrvatsko biofizičko društvo, 2018. str. 122-122
Tomić, Antonija ; Ramek, Michael ; Tomić, Sanja | Development of new parameters for the Zn2+ ion for the specific environment of the DPP III enzyme catalytic site // Computational Chemistry Day Book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2018. str. 15-15
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Tomin, Marko ; Tomić, Sanja | Mehanizam hidrolize peptidne veze na modelnom sustavu DPP III iz Bacteroides thetaiotaomicron // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2018. str. 36-36
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Ćehić, Mirsada ; Suć, Josipa ; Jerić, Ivanka ; Piantanida, Ivo ; Tomić, Sanja ; Schmuck, Carsten | Experimental study of new guanidiniocarbonyl-pyrrole-aryl conjugates as potential inhibitors of human dipeptidyl peptidase III // 4th Young Medicinal Chemist Symposium (EFMC-YMCS 2017) : Book of Abstracts. | Beč: EFMC-YMCS, 2017. str. 141-141
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Matić, Sara ; Karačić, Zrinka ; Gruber, Karl ; Tomić, Sanja | Combination of SAXS and molecular modeling in structure-function characterization of the plant DPP III orthologue // 7th Visegrad Symposium on Structural Systems Biology : Program & Abstracts. | Nové Hrady, 2017. str. P6-P6
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Tomin, Marko ; Tomić, Sanja | Computational study of dipeptidyl peptidase III from thermophile Caldithrix abyssi // Math/Chem/Comp 2017, 29th MC2 Conference : Book of Abstracts. | 2017. str. 16-16
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Tomin, Marko ; Tomić, Sanja | Conformational study of Bacteroides thetaiotaomicron dipeptidyl peptidase III // Conference proceedings, ICBMB 2016. | 2016. str. 23-23
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Tomin, Marko ; Tomić, Sanja ; Sabljić, Igor | Conformational study of Bacteroides thetaiotaomicron dipeptidyl peptidase III // Simpozij studenata doktorskih studija PMF : Knjiga sažetaka. | Zagreb, 2016. str. 40-40
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Tomić, Sanja | Understanding substrate recognition and function of human dipeptidyl peptidase III // Regional Biophysics Conference (RBC2016) - Book of Abstracts / EUT Edizioni Università di Trieste (ur.). | Trst: EUT Edizioni Università di Trieste, 2016. str. 9.-9
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Tomin, Marko ; Tomić, Sanja ; Sabljić, Igor | Bacteroides thetaiotaomicron dipeptidyl peptidase III complexes with synthetic substrates // ECS3 Book of Abstracts. | Zagreb: Hrvatska udruga kristalografa, 2016. str. 14-14
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Tomić, Sanja ; Tomić, Antonija ; Gundić, Mario | Influence of ligands and protein binding to structure and flexybility of human dipeptidyl peptidase III // Conference proceedings of ICBMB 2016, International Conference on Biochemistry and Molecular Biology. | 2016. str. 9-9
biochem.conference-site.com Bertoša, Branimir ; Kazizić, Saša ; Mikleušević, Goran ; Štefanić, Zoran ; Narczyk, Marta ; Wielgus- Kutrowska, Beata ; Hajnić, Matea ; Leščić Ašler, Ivana ; Tomić, Sanja ; Tarnowski, Krzysztof et al. | Role of subunit-subunit interactions in the catalysis conducted by hexameric purine nucleoside phosphorylase. | 2015. str. 1-1
Grabar Branilović, Marina; Tomić, Sanja | Computational study of the IRES subdomain IIa structural plasticity and the ligand binding affinity // Chemistry towards Biology 7th Central European Conference - Book of Abstracts. | Katovice, 2014. str. P10-P10
Tomić, Antonija ; Tomić, Sanja | The recent findings on the zinc ion coordination and ligand binding in the human DPP III active site – implication on the chemical reaction mechanism // XXIII. hrvatski skup kemičara i kemijskih inženjera, knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013. str. 177-177
Tomić, Sanja ; Tomić, Antonija ; Brkić, Hrvoje | Elucidation of metal ion-binding sites in proteins // 6th Central Europe Conference - Abstracts of scientific contributions. | Trst: Universita degli studi di Trieste, 2013. str. oc15-oc15
Tomić, Antonija ; Tomić, Sanja | Molecular Mechanics - Poisson Boltzmann Surface Area calculations using AMBER program package - application to the human dipeptidyl petidase III // Computational Electrostatics for Biological Applications - Book of Abstract. | 2013. str. 39-39
Maršavelski, Aleksandra ; Tomić, Sanja | Substrate selectivity of atypical methanogenic-type Seryl-tRNA synthetases-computational approach // The 11th Greta Pifat-Mrzljak International School of Biophysics. | 2012
Tomić, Sanja ; Tomić, Antonija ; Gonzalez, Miguel | Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity. | 2012
Tomić, Sanja ; Grabar, Marina ; Piantanida, Ivo | Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic response's // Book of Abstracts Regional Biophysical Conference 2012. | Beograd: Društvo biofizičara Srbije, 2012. str. 13-13
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Tomić, Antonija ; Tomić, Sanja | Further study of the zinc coordination in the active site of the human DPP III - ONIOM calculations // Book of abstracts, 11th Greta Pifat-Mrzljak International School of Biophysics, Biomolecular complexes and assemblies. | Zagreb: Institut Ruđer Bošković i Hrvatsko biofizičko društvo, 2012. str. 104-104
www.irb.hr Tomić, Antonija ; Tomić, Sanja | QM/MM study of the zinc coordination in the active site of the human DPP III // Knjiga sažetaka - IX. Susret mladih kemijskih inženjera. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2012. str. 173-173
Bertoša, Branimir ; Tomić, Sanja ; Aleksić, Maja ; Karminski-Zamola, Grace | Investigation of anticancer activity of heterocyclic amides and quinolones using 3D-QSAR analysis // Ninth Triennial Congress of the World Association ot Theoretical and Computational Chemists. | Santiago de Compostela, 2011. str. PII 016-x
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Tomić, Antonija ; Tomić, Sanja | MD simulations showed large conformational changes of the human free DPP III // Book of Abstracts - The Conference on Molecular Simulations in Biosystems and Material Science. | Konstanz, 2011. str. 72-72
cms.uni-konstanz.de Grabar, Marina ; Tomić, Sanja ; Tumir Marija, Lidija ; Piantanida, Ivo | Molecular modeling of new permanently charged phenanthridinium-nucleobase conjugates in complexes with double stranded polynucleotides // Ninth Triennial Congress of the World Association ot Theoretical and Computational Chemists - Book of Abstracts. | Santiago de Compostela, 2011. str. PII 017-x
Tomić, Sanja ; Brkić, Hrvoje ; Ramek, Michael ; Buongiorno, Daniele ; Straganz, Grit | Influence of The Hydrophobic Residues on The Dke1 Activity. | 2011. str. 1-1
Tomić, Antonija ; Tomić, Sanja | Human dipeptidyl-peptidases (h.DPP III), sampling the substrate binding site - computational analysis // Book of Abstracts of the "Fourth Humboldt Conference on Computational Chemistry". | Sofija, 2010. str. 63.-63.
Tomić, Antonija ; Tomić, Sanja | Natural vs. synthetic peptides binding to human dipeptidyl-peptidases (DPP III), computational insight // Book of Abstracts of the "Australia-Croatia Workshop on Antimicrobial Peptides and Summer School in Biophysics PhD Programme: AMP 2010". | Split: Faculty of Science, University of Split, 2010. str. 49.-49.
Burja, Bojan ; Čimbora-Zovko, Tamara ; Tomić, Sanja ; Jelušić, Tihana ; Kočevar, Marjan ; Polanc, Slovenko ; Osmak, Maja | Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies // Book od Abstract HDIR-1 From Bench to Clinic. | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2010. str. 73-73
Bertoša, Branimir ; Tomić, Sanja ; Aleksić, Maja ; Karminski-Zamola, Grace | QSAR analysis and proposal of new heterocyclic compounds with potential antitumor activity // The 5th Central European Conference - Chemistry towards Biology. | Zagreb: Institut Ruđer Bošković, 2010. str. 66-66
Grabar, Marina ; Tomić, Sanja ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Crnolatac, Ivo | Molecular modelling of phosphonium cyanine dyes in complex with DNA // The 5th Central European Conference - Chemistry towards Biology / Abramić, Marija ; Maksić, Zvonimir ; Salopek-Sondi, Branka et al. (ur.). | Zagreb: Institut Ruđer Bošković, 2010. str. 85-85
Grabar, Marina ; Tomić, Sanja ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Crnolatac, Ivo ; Deligeorgiev, Todor ; Vasilev, Alexey ; Kaloyanova, Stefka | Interaction of phosphonium cyanine dyes with DNA // Abstracts of the Fourth Humboldt Conference on Computational Chemistry. | Sofija, 2010. str. 62-x
Bertoša, Branimir ; Aleksić, Maja ; Karminski-Zamola, Grace ; Tomić, Sanja | QSAR analysis of heterocyclic amides and quinolones with potential antitumor activity // Math/Chem/Comp 2010, Program & book of abstracts. | Zagreb: Institut Ruđer Bošković, 2010. str. 7-7
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Tomić, Antonija ; Abramić, Marija ; Smith, David ; Tomić, Sanja | Molecular dynamics simulations of ligands binding into the active site of human dipeptidyl-peptidases (DPPIII) // Book of Abstracts of the EMBO Young Scientists Forum. | 2009. str. 53-53
bioinfo.hr Brkić, Hrvoje ; Grit, Straganz ; Tomić, Sanja ; Ramek, Michael | Molecular Modeling of Acetylacetone Dioxygenase from Acinobacter Jonsoii. | 2009
Grabar, Marina ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Tomić, Sanja | Computational approach to specificity of intercalators toward nucleotides // Book of Abstracts of the Tenth international summer school on biophysics - supramolecular structure and function. | Rovinj, 2009. str. 105-x
Grabar, Marina ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Tomić, Sanja | Computational and spectroscopic studies of intercalators and their interaction with nucleotides // Book of Abstracts of The third Adriatic Meeting on computational Solutions in the Life Sciences. | Zagreb: Institut Ruđer Bošković, 2009. str. 56-x
Savić, Bojana ; Tomić, Sanja ; Magnus, Volker ; Gruden, Kristina ; Barle, Katja ; Grenković, Renata ; Salopek-Sondi, Branka ; Jutta Ludwig-Müller | Auxin amidohydrolases from Brassica rapa cleave conjugates of indole propionic and indole butyric acid as preferable substrates: A biochemical and modeling approach // ACPD 2009, Auxins and Cytokinins in Plant Development, Book of Abstracts. | Prag, 2009. str. 22-22
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Tomić, Antonija ; Abramić, Marija ; Smith, David ; Tomić, Sanja | Computational and experimental approach to the study of ligands binding into the active site of the human dipeptidyl-peptidases (DPPIII) // Book of Abstracts of the "The 3rd Adriatic Meeting On Computational Solutions in the Life Sciences". | Zagreb: Centre for Computational Solutions in the Life Sciences, Ruđer Bošković Institute, 2009. str. 77-77
www.compsols.irb.hr Grabar, Marina ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Tomić, Sanja | Bisphenanthridinium-nucleobase conjugates – molecular modelling and spectroscopic approach // Book of Abstracts of the EMBO Young Scientists Forum. | Zagreb, 2009
Grabar, Marina ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Tomić, Sanja | Molecular modelling of bisphenanthridinium- nucleobase conjugates // Book of Abstracts of the International Conference and Biophysics Summmer School From Solid State to Biophysics IV. | École polytechnique fédérale de Lausanne (EPFL), 2008
Grabar, Marina ; Tumir, Lidija-Marija ; Piantanida, Ivo ; Tomić, Sanja | Molecular modelling of bisphenanthridinium- nucleobase conjugates // Book of Abstracts of the MATH/CHEM/COMP - The Dubrovnik International Course on the Interfaces among Mathematics, Chemistry and Computer Sciences. | Zagreb: Institut Ruđer Bošković, 2008. str. 20-x
Šikić, Krešimir ; Tomić, Sanja ; Jeren, Branko | The protein structure flexibility // Proceedings of 23rd International Course on the Interfaces among Mathematics, Chemistry & Computer Sciences. | Zagreb, 2008
Tomić, Sanja | Force field based methods for computational study of macromolecules // Hottest Topics in Protein Research : Book of abstracts. | Zagreb, 2008. str. 7-8
Tomić, Sanja | Combined 3D QSAR and QM/MM Study of the Burkholderia cepacia Lipase Enantioselectivity // Protein Design and Evolution for Biocatalysis, Book of Abstracts. | 2008
Savić, Bojana ; Tomić, Sanja ; Magnus, Volker ; Salopek-Sondi, Branka | BrILL2, auksin amidohidrolaza iz kineskog kupusa (Brassica rapa L.) // Zbornik sažetaka. | Zagreb: Institut Ruđer Bošković, 2008. str. 74-74
Salopek-Sondi, Branka ; Savić, Bojana ; Tomić, Sanja ; Magnus, Volker | Insight into structure and function of the plant enzyme, auxin amido-hydrolase // Book of abstracts of the HDBMB 2008. | Osijek: Hrvatsko Društvo za Biotehnologiju, 2008. str. 130-130
Vujasinović, Ines ; Bertoša, Branimir ; Tomić, Sanja ; Mlinarić-Majerski, Kata | Influence of the rigid spacer to macrocyclization of poly(thialactones): Synthesis and computational analysis // IUPAC Conference Santiago de Compostela. | Santiago de Compostela, 2008
Tomić, Sanja ; Ceilinger, Igor ; Janežić, Dušanka ; Hodošček, Milan | Towards understanding enentio-selective enzyme catalysed chemical transformation of pro-drugs // Abstracts book. | Atena: University of Athens, 2008. str. 35-35
Tomić, Sanja ; Ceilinger, Igor ; Hodošček, Milan ; Janežić, Dušanka | QM/MM Study of the Burkholderia cepacia Lipase Catalyzed Secondary Alcohol Esterification // Book of Abstracts - The Conference on Molecular Simulations in Biosystems and Material Science. | Konstanz: Universitaet Konstanz, 2008. str. 92-92
Tomić, Sanja | Proučavanje međudjelovanja proteina korištenjem računala // Knjiga sažetaka 5. znanstvenog sastanka Hrvatskog fizikalnog društva. | Zagreb, 2007. str. 56-x
Šikić, Krešimir ; Tomić, Sanja ; Branko, Jeren | New methods of finding flexibility in proteins // The 2th Opatija Meeting on Computational Solutions in the Life Sciences. | Zagreb: Institut Ruđer Bošković, 2007. str. 86-x
Dokmanić, Ivan ; Šikić, Mile ; Tomić, Sanja | Correlating protein surface shape and hydrophobicity using spherical harmonical expansions // Book of abstracts, The 2nd Opatija Meeting on Computational Solutions in the Life Sciences. | Zagreb: Institut Ruđer Bošković, 2007. str. 69-69
Bertoša, Branimir ; Wade, Rebecca ; Kojić-Prodić, Biserka ; Tomić, Sanja | Computational simulations of ABP1 and its interactions with auxin-related molecules // The 2th Opatija Meeting on Computational Solutions in the Life Sciences. | Zagreb: Institut Ruđer Bošković, 2007. str. 30-30
Tomić, Sanja ; Dokmanić, Ivan | Divalent metal cations in proteins: abundance, coordination, function // Book of Abstracts: 16th CROATIAN-SLOVENIAN CRYSTALLOGRAPHIC MEETING. | Zagreb: Hrvatska akademija znanosti i umjetnosti (HAZU), 2007. str. 54-54
Tomić, Sanja ; Wade, Rebecca ; Wang, Ting ; Bertoša, Branimir ; Gabdoulline, Razif | The protein-protein interactions- molecular modelling study // 6th Central European Symposium on Theoretical Chemistry - Book of Abstracts. | Graz: TU-Graz, 2007. str. L12-L12
Tomić, Sanja ; Bertoša, Branimir ; Wade, C. Rebecca | Non covalent interactions in protein complexes // Humboldt Conference On Noncovalent Interactions. | Vršac: AvH, 2007. str. 12-12
Bertoša, Branimir ; Tomić, Sanja ; Kojić-Prodić, Biserka | Investigation of Auxin Binding to ABP1 by Computational Methods // Supramolecular Structure and Function. | Zagreb, 2006. str. 99-x
Tomić, Sanja ; Bertoša, Branimir | Study of protein specificity and selectivity by computational methods // Third Humboldt Conference on Computational Chemistry. | Sofija: Avangard Prima, 2006. str. 26-26
Ceilinger, I. ; Tomić, Sanja ; Hodošček, M. ; Janežič, D. | QM/MM Study of the Burkholderia cepacia Lipase Catalysed Secondary Alcohol Esterification // Through Science to Stability. Proceedings of the 1^st South Eastern European Workshop on Practical Approaches to Computational Biology. | Zagreb: Institut Ruđer Bošković, 2005. str. 43-43-x
Tomić, Sanja ; Ramek, Michael | Study of Lipase Enantioselectivity // IXX. hrvatski skup kemičara i kemijskih inženjera. Knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2005. str. 89-89
Bertoša, Branimir ; Tomić, Sanja ; Babić, Darko | Molecular Dynamics Simulations of Auxin Binding Protein1 // Through science to stability : 1st South Eastern European workshop on practical approaches to computational biology. | 2005. str. 60-60-x
Bertoša, Branimir ; Tomić, Sanja | INVESTIGATION OF PROTEIN-PROTEIN INTERACTIONS USING COMBINE ANALYSIS // XIX. hrvatski skup kemičara i kemijskih inžinjera, Knjiga sažetaka. | Zagreb, 2005. str. 217-x
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Kojić-Prodić, Biserka ; Kovačić, Filip ; Wilhelm, Susanne ; Tomić, Sanja ; Jager, Karl-Erich | Bioinformatics Approach to Characterisation of SGNH Hydrolase // XX Congress of International Union of Crystallography, Book of Abstracts, Acta Cryst A61, Supplement. | Firenza : München: International Union of Crystallography, 2005. str. C42-x
journals.iucr.org Tomić, Sanja | Theoretical study of enzyme specificity and selectivity // Regional Biophysics Meeting 2005: Book of abstracts. | Slovenian Biophysical Society, 2005. str. 10-10-x
Tomić, Sanja | Rational Approach In Modifying Enzyme Specificitity // Devide & Conquere: Assembling Leads from Fragments- Disassembling Protein Complexes. | University of Marburg, 2005. str. 43-43-x
Tomić, Sanja ; Bertoša, Branimir ; Kojić-Prodić, Biserka | Study of lipase stereoselectivity by computational methods // 2nd Central European Conference Chemistry towards Biology. | Graz: Universitaet Graz, 2004. str. 67-67-x
Tomić, Sanja ; Bertoša, Branimir | Proučavanje specifičnosti enzima računskim metodama // Znanstvena konferencija promicanje ideja fizike. | Zagreb: Institut za fiziku, 2004. str. 19-19-x
Tomić, Sanja | Changing enzyme specificity // BRIJUNI Conference (Matter under extreme conditions). | Zagreb: Institut Ruđer Bošković, 2004
Bertoša, Branimir ; Tomić, Sanja ; Kojić-Prodić, Biserka | New classification procedure for biologically active compounds based on similarity of their molecular interactions and logP prediction // Zbornik sažetaka postera znanstvenih novaka izlaganih u inozemstvu 2002., 2003. i 2004. godine. | Zagreb, 2004. str. 15-16-x
Wang, Ting ; Tomić, Sanja ; Gabdoulline, Razif ; Wade, Rebecca | Comparative binding energy (combine) analysis of barnase-barstar inter facial mutants // MATH/CHEM/COMP/2003: Program and Book of Abstracts. | Zagreb: Institut Ruđer Bošković, 2003. str. 92-x
Bertoša, Branimir ; Kolossvary, Istvan ; Kojić-Prodić, Biserka ; Tomić, Sanja | Molecular modelling and 3D QSAR study on burkholderia cepacia catalysed resolution of diverse secondary alcohols. | Zagreb: Institut Ruđer Bošković, 2003. str. 9-9-x
Tomić, Sanja ; Bertoša, Branimir ; Kojić-Prodić, Biserka | Classification of auxin related compounds based on similarity of their molecular interactions fields and logP prediction // XVIII. hrvatski skup kemičara i kemijskih inžinjera, Sažetci, abstract. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2003. str. 134-134-x
Antolić, Snježana ; Dolušić, Eduard ; Bertoša, Branimir ; Kojić-Prodić, Biserka ; Magnus, Volker ; Salopek-Sondi, Branka ; Tomić, Sanja | Molecular recognition of auxins - a rational approach to plant growth regulation // Book of Abstracts, First Croatian Congress on Molecular Life Sciences (ISBN 953-6256-13-4). | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002. str. 84-84-x
Ramek, Michael ; Tomić, Sanja | Theoretical Structure Investigation of 2-Methyl-3-Indole Acetic Acid // Conference proceeding. | Austin (TX): University of Austin, 2002. str. 00-00-x
Bertoša, Branimir ; Tomić, Sanja ; Kojić-Prodić, Biserka | New classification procedure for biologically active compounds based on similarity of their molecular interactions and logP prediction // Humboltd research conference on computational chemistry-book of abstracts. | Sofija, 2002. str. 72-72-x
Kojić-Prodić, Biserka ; Magnus, Volker ; Tomić, Sanja ; Antolić, Snježana ; Salopek-Sondi, Branka ; Dolušić, Eduard ; Bertoša, Branimir | Molecular recognition of the plant hormone auxin is still a puzzle // Abstracts, XIX Congress and General Assembly of the International Union of Crystallography [Acta Crystallographica A58 (Supplement)]. | Chester: International Union of Crystallography, 2002. str. C139-C139-x
Tomić, Sanja | Molecular modeling and 3D QSAR approach to molecular recognition // CC1MLIS Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002. str. 112-x
Tomić, Sanja | Enantioselectivity of Burkholderia cepacia lipase towards primary and secondary alcohols: molecular modelling and 3D QSAR analysis // EURO QSAR 2002, Book of Abstracts. | Portsmouth: University of Portsmouth, 2002. str. Poster No 072-x
Bertoša, Branimir ; Tomić, Sanja ; Ramek, M. ; Wade, R. ; Kojić-Prodić, Biserka | New classification procedure for biologically active compounds based on similarity of their molecular interactions and logP prediction // First Central European Conference: "CHEMISTRY TOWARDS BIOLOGY". | Ljubljana, 2002. str. 134-134
Tomić, Sanja ; Luić, Marija ; Šepac, Dragan ; Leščić, Ivana ; Ljubović, Edina ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Molecular modeling of the complex of 1-phenoxy-2- butanol with acetyl -pseudomonas cepacia lipase (PCL), and its p-transition state analog in comparison with the experimental results // Rational approaches to drug design: Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships. | Düsseldorf: Prous Science, Barcelona, 2001. str. 69-73
Tomić, Sanja ; Luić, Marija ; Kojić-Prodić, Biserka | Influence of water molecules in the crystal structure of Pseudomonas Cepacia Lipase on secondary alcohol binding modes scoring and on model for predicting enantioselectivity // Tenth Cro-Slo crystallographic Meeting, Book of Abstracts. | Zagreb: Sveučilište u Zagrebu, 2001. str. 27-27-x
Tomić, Sanja | Enantioselectivity of the Pseudomonas Cepacia Lipase Toward 3-(Ariloxy)-1,2-Propanediols // MATH/CHEM/COMP. | Zagreb: Institut Ruđer Bošković, 2001. str. 96-96-x
Tomić, Sanja ; Ljubović, Edina ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Molecular Modeling of the Enantioselectivity of Pseudomonas Cepacia Lipase Towards Some Secondary and Primary Alcohols // DU 2000 NMR. | Dubrovnik: Inter-University Center, 2000. str. 45-45-x
Ramek, Michael ; Tomić, Sanja | Theoretical Structure Investigations of 3-Indole Acetic Acid Derivatives // Conference proceeding. | Austin (TX): University of Austin, 2000. str. 00-00-x
Tomić, Sanja ; Wade, Rebecca | QSAR-COMBINE Analysis of Nuclear Receptor-DNA Binding // DU 2000 NMR. | Dubrovnik: Inter-University Center, 2000. str. 46-46-x
Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schroeder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | A contribution to understanding of enzymatic activity of bacterial lipases. // Workshop of Challenges in Crystallography of Macromolecular Assemblies. | Trst: Synchrotron Trieste, 2000. str. 24-24-x
Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schröder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | "Structure is function": A contribution to understanding enzymatic activity of bacterial lipases. // Kongres hrvatskih biokemičara i molekularnih biologa, HB 2000. Knjiga sažetaka.. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 46-46-x
Magnus, Volker ; Antolić, Snježana ; Balón, Manuel ; Kojić-Prodić, Biserka ; Tomić, Sanja ; Vikić-Topić, Dražen | The electronic structure of auxin molecules correlates with their biological activity // EMBO Workshop on Auxin. | Calcatoggio, 2000. str. 58-58-x
Tomić, Sanja ; Wade, Rebecca | QSAR-COMBINE analysis of nuclear receptor-DNA binding // EUKO-CC3. | Budimpešta: Hungarian Chemical Society, 2000. str. 27-x
Ramek, Michael ; Tomić, Sanja | Ab Initio RHF Conformational Analysis of the Auxin Phytohormone 4-Methyl-3-Indole Acetic Acid // Conference proceeding. | St. Augustine (FL): University of Florida, 1999. str. 00-00-x
Tomić, Sanja ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Enantioselectivity of acylation by Pseudomonas cepacia lipase - COMBINE analysis // 13. Darmstaedter Molecular-Modelling Workshop. | Darmstadt: Technische Universitaet Darmstadt, 1999. str. 18-x
Ramek, Michael ; Tomić, Sanja | Conformational Analysis of the Phytohormones x-Ethyl-3-Indole Acetic Acid (x = 4, 5, 6) // Conference proceeding. | St. Augustine (FL): University of Florida, 1998. str. 00-00-x
Kojić-Prodić, Biserka ; Antolić, Snježana ; Tomić, Sanja ; Magnus, Volker | Molecular recognition of the phytohormone auxin and related compounds // Collected Abstracts-XVII. congress and general assembly, International union of crystallography. | Seattle (WA): International Union of Crystallography, 1996. str. C417-C417-x
Kveder, Marina ; Tomić, Sanja ; Kidrič, Jurka ; Kojić-Prodić, Biserka ; Čudić, Mare ; Horvat, Jaroslav ; Horvat, Štefica | Comparative conformational analysis of 1-(6-deoxy-1,2:3,4-di-O-isopropylidene-alpha-D-galactos-6-yl) 2,5-piperazinedione based on experimental evidences and computer modelling // Book of Abstracts. | Zagreb: Hrvatsko biokemijsko društvo, 1996. str. 72-72-x
Antolić, Snježana ; Kojić-Prodić, Biserka ; Tomić, Sanja ; Magnus, Volker ; Cohen, Jerry D. | Structure-Activity Correlations for Ring-Fluorinated Indole-3-Acetic Acids // Program-Abstracts. 15^th International Conference on Plant Growth Substances. | Minneapolis (MN): International Plant Growth Substances Association, 1995. str. 245-245-x
Kojić-Prodić, Biserka ; Nigović, Biljana ; Tomić, Sanja ; Ilić, Nebojša ; Magnus, Volker ; Giba, Zlatko ; Konjević, Radomir | Structural studies on 5-(n-alkyl)-substituted derivatives of the plant hormone, indol-3-ylacetic acid // Abstracts, 14th International Conference on Plant Growth Substances (IPGSA 1991). | Amsterdam: Landbouwuniversitet Wageningen, 1991. str. 68-68
Stručni rad
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Tomić, Sanja | Život modeliran vodom // Fizikalni aspekti vode. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2008. str. 50-57
www.hfd.hr Tomić, Sanja | Razotkrivanje tajni (za život važnih) molekula // Fizika u temeljima suvremene znanosti i društva. Zbornik predavanja 21. ljetne škole mladih fizičara. | Zagreb: Hrvatsko fizikalno društvo, 2005. str. 41-46-x
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Tomić, Sanja | Modelling - a connection between structure and activity // Znanstveni projekti i programi. | 2004
www.humboldt-club.hr
Izvorni znanstveni rad
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Agić, Dejan; Bešlo, Drago; Lučić, Bono; Tomić, Sanja; Blagojević, Bojana; Popović, Boris M. | Computational study on the interactions of quercetin 3-O-rutinoside with human DPP III // Book of Proceedings, 2nd International Conference on Chemo and Bioinformatics / Marković, Zoran; Filipović, Nenad (ur.). | Kragujevac: University of Belgrade, 2023. str. 629-632. doi: 10.46793/iccbi23.629a
doidoi.ub.kg.ac.rs Tomić, Sanja ; Brkić, Hrvoje ; Grabar Branilović, Marina ; Tomić, Antonija ; Branimir, Bertoša ; Mile, Šikić | Proteini i nukleinske kiseline u vremenu i prostoru // Bioinformatics and biological physics: proceedings of the scientific meeting. | Zagreb: Hrvatska akademija znanosti i umjetnosti (HAZU), 2013. str. 149-157
Šikić, Krešimir ; Tomić, Sanja ; Jeren, Branko | The protein secondary structure flexibility // Proceedings of the 2008 International Conference on Bioinformatics & Computational Biology. | 2008. str. 918-926
Šikić, Krešimir ; Tomić, Sanja, Jeren, Branko | Identifying protein flexibility by NMA // Proceedings of the 2008 International Conference on Bioinformatics & Computational Biology. | 2008. str. 927-933
Ostalo
Tomić, Sanja ; Abramić, Marija ; Brkić, Hrvoje ; Tomić, Antonija | Sprega kristalografije i modeliranja u proučavanju bioloških makromolekula // Kristalografija u Hrvatskoj. | Zagreb: Hrvatska akademija znanosti i umjetnosti (HAZU), 2013. str. 129-137
Publikacije - prilozi sa skupa (u časopisu)
Sažetak izlaganja sa skupa
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Tomić, Sanja ; Kazazić, Saša ; Abramić, Marija ; Tomin, Marko ; Agić, Dejan ; Karačić, Zrinka ; Grabar-Branilović, Marina | H/D exchange and MD simulation study of dipeptidyl peptidase III intrinsic dynamics and ligand binding // European biophysics journal, 46, 2017. str. S179-S179
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Tomić, Sanja ; Kovačević, Borislav ; Tomić, Antonija ; Matovina, Mihaela ; Karačić, Zrinka ; Matić, Sara ; Abramić, Marija ; Agić, Dejan | Understanding h.DPP III mechanism – an aid in rationalization of the mutants (in)activity // European biophysics journal, 46, 2017. str. S179-S179
link.springer.comlink.springer.com Grabar Branilović, Marina ; Smolko, Ana ; Šupljika, Filip ; Salopek-Sondi, Branka ; Piantanida, Ivo ; Tomić, Sanja | Brassica rapa auxin-amidohydrolase: the Mn2+ binding affinities and the active site structure // European biophysics journal, 2015. str. 166-166
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Grabar Branilović, Marina ; Smolko, Ana ; Šupljika, Filip ; Salopek-Sondi, Branka ; Piantanida, Ivo ; Tomić, Sanja | The active site structure of manganese-containing Brassica rapa auxin-amidohydrolase BrILL2 // Acta crystallographica. Section A, Foundations and advances, 2015. str. 210-210. doi: 10.1107/S2053273315096849
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Tomin, Marko ; Tomić, Sanja ; Sabljić, Igor | Conformational study of Bacteroides thetaiotaomicron dipeptidyl peptidase III // Acta crystallographica. Section A, Foundations and advances, 2015. str. 209-209. doi: 10.1107/S2053273315096850
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Tomić, Sanja ; Tomić, Antonija | Ligand binding to the flexible metaloenzymes: protein dynamics and the active enzyme conformation // European biophysics journal, 44, Suppl. 1, 2015. str. 243-243. doi: 10.1007/s00249-015-1045-6
doilink.springer.com Tomić, Sanja ; Brkić, Hrvoje ; Straganz, Grit ; Buongiorno, daniela | Non-heme iron dependent enzymes – understanding transport of iron cation in acetylacetone dioxygenase from Acinetobacter johnsoii // European biophysics journal, 2013. str. S184-S184
Savić, Bojana ; Ludwig-Müller, Jutta ; Tomić, Sanja ; Magnus, Volker ; Salopek-Sondi, Branka | Characterization of the Brassica rapa auxin amido-hydrolase, BrILL2 // Physiologia plantarum, 2008. str. P01-065-P01-065
Publikacije - prilozi sa skupa (neobjavljeni)
Neobjavljeni prilog sa skupa
Kekez, Ivana; Matić, Sara; Matovina, Mihaela; Tomić, Sanja; Matković-Čalogović, Dubravka | Crystallization of the Keap1-DPP III complex // Hot Topics in Contemporary Crystallography 5 - HTCC5 | Dubrovnik, Hrvatska, 16.04.2023-21.04.2023
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Karačić, Zrinka ; Šupljika, Filip ; Tomašić Paić, Ana ; Brkljačić, Lidija ; Tomić, Sanja | Role of dipeptidyl peptidase III in pain regulation through cleavage of neuropeptides // 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) and 5th Symposium Vladimir Prelog | Veli Lošinj, Hrvatska, 05.10.2021-08.10.2021
27hskiki.hkd.hr Matić, Sara; Matovina, Mihaela; Tomić, Sanja | Exploring the effect of mutations on interactions between Keap1 and DPP III by MD simulations // EMBO Workshop: Integrating genomics and biophysics to comprehend functional genetic variation | Torino, Italija, 08.09.2017-10.09.2017
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Tomin, Marko ; Tomić, Sanja ; Sabljić, Igor | Bacteroides thetaiotaomicron dipeptidyl peptidase III complexes with synthetic substrates // Thrid DPP III Minisymposium | Graz, Austrija, 10.02.2017-10.02.2017
www.irb.hr Brkić, Hrvoje ; Straganz, Grit ; Buongirno, Daniela ; Ramek, Michael ; Tomić, Sanja | Diketone cleaving dioxygenase - theoretical study // 5th Central European Conference "Chemistry Towards Biology" | Primošten, Hrvatska, 08.09.2010-11.09.2010
Tomić, Sanja | Modeliranje bioloških molekula i njihovih kompleksa // Bioinformatika IRB - 2004 | Zagreb, Hrvatska, 10.12.2004-10.12.2004
Publikacije - ocjenski radovi
Doktorski rad
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Ćehić, Mirsada | Eksperimentalno i računalno istraživanje novih konjugata gvanidina s različitim fluoroforima kao liganada humane dipeptidil-peptidaze III / Tomić, Sanja ; Piantanida, Ivo (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2019
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Tomić, Antonija | Primjena računalnih pristupa različitih stupnjeva složenosti u svrhu razumijevanja strukture, dinamike i aktivnosti ljudske dipeptidil-peptidaze III / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2015
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Grabar Branilović, Marina | Eksperimentalno utemeljeno modeliranje interakcija nukleinskih kiselina i malih molekula / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2014
fulir.irb.hrrepozitorij.pmf.unizg.hr Brkić, Hrvoje | Proučavanje o željezu ovisnih dioksigenaza računalnim metodama / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2014
Šikić, Krešimir | Algoritmi za utvrđivanje fleksibilnosti proteina na temelju konformacije i fizikalnih svojstava proteina / Jeren, Branko (mentor); Tomić, Sanja (neposredni voditelj) . | Zagreb, Fakultet elektrotehnike i računarstva, 2008
Bertoša, Branimir | Modeliranje auksinskih molekula i njihove interakcije s veznim proteinom - ABP 1 / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007
Diplomski rad (sveučilišni)
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Hanić, Maja | Interdisciplinarno istraživanje mutanata R620C, R623W i R623L ljudske dipeptidil-peptidaze III / Matovina, Mihaela ; Tomić, Sanja (mentor); Matić, Sara (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2020
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Čavka, Ivana | Računalne simulacije kompleksa ljudske dipeptidil-peptidaze III s angiotenzinom-(1-7) i njegovim stabilnim analogom / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2018
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Tir, Nora | Simulacije molekulske dinamike kompleksa ljudske dipeptidil-peptidaze III s inhibitorima / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2016
repozitorij.pmf.unizg.hr Šimunović, Mijo | Thermodynamics of ligand binding to auxin amidohydrolase / Cvitaš, Tomislav (mentor); Tomić, Sanja (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2010
Ceilinger, Igor | Modeliranje enzimske esterifikacije sekundarnog alkohola korištenjem QM/MM pristupa / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2006
Publikacije - druge vrste radova
Ostalo
Šikić, Krešimir ; Jeren, Branko ; Tomić, Sanja | THE PROTEIN SECONDARY STRUCTURE FLEXIBILITY // MATH/CHEM/COMP 2008 - Book of Abstracts, 2008
Kratak opis tekućeg istraživačkog projekta („Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka“, IP-2018-01-2936)
Egzopeptidaza dipeptidil peptidaza III (DPP III) posljednjih je godina privukla pozornost istraživačkih skupina diljem svijeta. Široko je zastupljena u tkivu sisavaca i smatra se da sudjeluje u završnim koracima normalnog intracelularnog katabolizma proteina. Međutim, izraženi afinitet za neke bioaktivne peptide (angiotenzin II i III, te opioidne peptide) sugerira njene specifične funkcije. Također, raste broj eksperimentalnih dokaza koji upućuju na uključenost DPP III u razvoj nekih karcinoma kod ljudi. Ipak, poznavanje njene točne uloge u tim procesima još uvijek nije zadovoljavajuća. Cilj predloženog istraživanja je unaprijediti znanje o biološkoj važnosti ovog cink-veznog metaloenzima i njegovom utjecaju na ljudsko zdravlje. U tu svrhu planiramo slijedeće aktivnosti: (1) razvoj novih parametara za ion cinka u proteinima i optimizacija računalnih pristupa u proučavanju metaloenzimske strukture, te kombinirana, računalna i eksperimentalna studija ionske izmjene metala kod ljudske DPP III (hDPP III), uključujući identifikaciju potencijalnog inhibitornog veznog mjesta za metal, (2) istraživanje uključenosti hDPP III u signalni put Keap1-Nrf2- kako bi se rasvijetlila njezina uloga u oksidativnom stresu, (3) proširenje saznanja o prirodnim supstratima hDPP III kod čovjeka i (4) ispitivanje novih, moćnih inhibitora katalitičke funkcije hDPP III. U svrhu diseminacije saznanja o važnosti DPP III i unapređenja suradnje s inozemnim znanstvenim institucijama, planiramo predstaviti naše rezultate na međunarodnim konferencijama i organizirati simpozij o DPP III.
Iako je element u tragovima, cink ima značajnu ulogu u ljudskom zdravlju. Poznato je da ima aktivnu ulogu u hidrolizi peptida kataliziranoj hDPP III, ali ništa nije poznato o potencijalnom inhibitornom metalnom veznom mjestu. Također, nije poznat mehanizam izmjene metala u hDPP III. Parametri za cink koje smo koristili u prethodnim simulacijama molekularne dinamike (MD) DPP III ortologa omogućili su nam pouzdano modeliranje enzimske strukture i fleksibilnosti, tj. rezultati simulacija odgovarali su onima dobivenim eksperimentalnim metodama. Međutim, primijetili smo snažnu preferenciju za oktaedarsku koordinaciju cinka, čak i u najkompaktnijoj strukturi kompleksa enzim-supstrat za koju su izračuni kvantne i molekularne mehanike (QMMM) za mehanizam reakcije sugerirali tetraedarsku koordinaciju Zn2+ kao najpovoljniju za reaktant. Kako bismo osigurali pouzdanost molekulskog modeliranja procesa u kojima je metalni ion u središtu interesa razvit ćemo nove parametre za Zn2+. U tu svrhu koristit ćemo QM i QMMM metode u kombinaciji s MD simulacijama i mikrokalorimetrijom.
Kako bismo utvrdili ulogu DPP III u karcinogenezi, istražit ćemo njenu uključenost u signalni put Keap1-Nrf2 na molekularnoj razini. Kombinacija računalnog (all atom simulacije molekulske dinamike) i eksperimentalnog (kinetički, spektrometrijski, strukturni i termodinamički) pristupa može nam omogućiti napredak u razumijevanju molekularne osnove interakcija hDPP III- Keap1 i njihov utjecaj na stanične procese.
Podaci o visokim koncentracijama DPP III u površinskim lamelama stražnjih rogova kralježnične moždine kod štakora, gdje se taj enzim lokalizira s enkefalinima i endomorfinima, zajedno sa spoznajom da DPP III može degradirati te opioidne peptide in vitro, potvrđuju ulogu DPP III u endogenom sustavu regulacije boli kod sisavaca. U sklopu ovog projekta planiramo ispitati seriju od oko 10 neuropeptida, računalno i eksperimentalno. Identifikacija potencijalnih supstrata među njima bila bi vrijedno otkriće za objašnjenje uloga DPP III kod čovjeka.
Također, istražit će se mogućnost vezanja na hDPP III za niz fluorescentnih gvanidinijevih karbonil-pirol konjugata. Kinetičke, fluorimetrijske i mikrokalorimetrijske studije njihovog vezanja na divlji tip hDPP III i njen katalitički inaktivni mutant E451A bit će kombinirane s MD simulacijama i izračunima slobodne energije vezanja.
Konačno, naša bi istraživanja trebala unaprijediti poznavanje molekularne osnove interakcija protein-protein (DPP III - Keap1) i protein-ligand (DPP III - peptidi /inhibitori), te njihovu povezanost sa staničnim procesima, kao i rasvijetliti biološku ulogu hDPP III. Studija bi trebala predložiti smjernice za razvoj farmakoloških molekula s mogućnošću kontrole mehanizama u kojima sudjeluje hDPP III. Konačno, novo razvijeni parametri za ion cinka bit će korisni ne samo za DPP III, već i za ostale proteine sa sličnim veznim mjestom za cink.